Literature DB >> 20090894

Measuring cis-acting regulatory variants genome-wide: new insights into expression genetics and disease susceptibility.

Wolfgang Sadee1.   

Abstract

A recent large-scale allelic expression analysis shows that cis-acting regulatory variants might reveal some of the 'missing heritability' component of complex disorders, which could lead to potential therapy and prevention breakthroughs.

Entities:  

Year:  2009        PMID： 20090894      PMCID： PMC2808732          DOI： 10.1186/gm116

Source DB:  PubMed          Journal:  Genome Med        ISSN： 1756-994X            Impact factor:   11.117


  25 in total

1.  Common genetic variants account for differences in gene expression among ethnic groups.

Authors:  Richard S Spielman; Laurel A Bastone; Joshua T Burdick; Michael Morley; Warren J Ewens; Vivian G Cheung
Journal:  Nat Genet       Date:  2007-01-07       Impact factor: 38.330

Review 2.  The evolutionary significance of cis-regulatory mutations.

Authors:  Gregory A Wray
Journal:  Nat Rev Genet       Date:  2007-03       Impact factor: 53.242

3.  Polymorphisms affecting gene transcription and mRNA processing in pharmacogenetic candidate genes: detection through allelic expression imbalance in human target tissues.

Authors:  Andrew D Johnson; Ying Zhang; Audrey C Papp; Julia K Pinsonneault; Jeong-Eun Lim; David Saffen; Zunyan Dai; Danxin Wang; Wolfgang Sadée
Journal:  Pharmacogenet Genomics       Date:  2008-09       Impact factor: 2.089

4.  Gene regulation for higher cells: a theory.

Authors:  R J Britten; E H Davidson
Journal:  Science       Date:  1969-07-25       Impact factor: 47.728

5.  Tryptophan hydroxylase 2 (TPH2) haplotypes predict levels of TPH2 mRNA expression in human pons.

Authors:  J-E Lim; J Pinsonneault; W Sadee; D Saffen
Journal:  Mol Psychiatry       Date:  2006-12-12       Impact factor: 15.992

6.  Regulatory polymorphism in vitamin K epoxide reductase complex subunit 1 (VKORC1) affects gene expression and warfarin dose requirement.

Authors:  Danxin Wang; Huizi Chen; Kathryn M Momary; Larisa H Cavallari; Julie A Johnson; Wolfgang Sadée
Journal:  Blood       Date:  2008-06-03       Impact factor: 22.113

7.  Genome-wide analysis of allelic expression imbalance in human primary cells by high-throughput transcriptome resequencing.

Authors:  Graham A Heap; Jennie H M Yang; Kate Downes; Barry C Healy; Karen A Hunt; Nicholas Bockett; Lude Franke; Patrick C Dubois; Charles A Mein; Richard J Dobson; Thomas J Albert; Matthew J Rodesch; David G Clayton; John A Todd; David A van Heel; Vincent Plagnol
Journal:  Hum Mol Genet       Date:  2010-01-01       Impact factor: 6.150

8.  Digital RNA allelotyping reveals tissue-specific and allele-specific gene expression in human.

Authors:  Kun Zhang; Jin Billy Li; Yuan Gao; Dieter Egli; Bin Xie; Jie Deng; Zhe Li; Je-Hyuk Lee; John Aach; Emily M Leproust; Kevin Eggan; George M Church
Journal:  Nat Methods       Date:  2009-07-20       Impact factor: 28.547

9.  Validating discovered Cis-acting regulatory genetic variants: application of an allele specific expression approach to HapMap populations.

Authors:  Susana Campino; Julian Forton; Srilakshmi Raj; Bert Mohr; Sarah Auburn; Andrew Fry; Valentina D Mangano; Claire Vandiedonck; Anna Richardson; Kirk Rockett; Taane G Clark; Dominic P Kwiatkowski
Journal:  PLoS One       Date:  2008-12-31       Impact factor: 3.240

10.  Differential allelic expression in the human genome: a robust approach to identify genetic and epigenetic cis-acting mechanisms regulating gene expression.

Authors:  David Serre; Scott Gurd; Bing Ge; Robert Sladek; Donna Sinnett; Eef Harmsen; Marina Bibikova; Eugene Chudin; David L Barker; Todd Dickinson; Jian-Bing Fan; Thomas J Hudson
Journal:  PLoS Genet       Date:  2008-02-29       Impact factor: 5.917
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  13 in total

Review 1.  Pharmacogenomics of the RNA world: structural RNA polymorphisms in drug therapy.

Authors:  W Sadee; D Wang; A C Papp; J K Pinsonneault; R M Smith; R A Moyer; A D Johnson
Journal:  Clin Pharmacol Ther       Date:  2011-02-02       Impact factor: 6.875

Review 2.  Pharmacogenomic biomarkers: validation needed for both the molecular genetic mechanism and clinical effect.

Authors:  Wolfgang Sadee
Journal:  Pharmacogenomics       Date:  2011-05       Impact factor: 2.533

3.  Evidence of allelic imbalance in the schizophrenia susceptibility gene ZNF804A in human dorsolateral prefrontal cortex.

Authors:  Ilaria Guella; Adolfo Sequeira; Brandi Rollins; Ling Morgan; Richard M Myers; Stanley J Watson; Huda Akil; William E Bunney; Lynn E Delisi; William Byerley; Marquis P Vawter
Journal:  Schizophr Res       Date:  2013-12-07       Impact factor: 4.939

Review 4.  Pharmacogenomic testing: relevance in medical practice: why drugs work in some patients but not in others.

Authors:  Joseph P Kitzmiller; David K Groen; Mitch A Phelps; Wolfgang Sadee
Journal:  Cleve Clin J Med       Date:  2011-04       Impact factor: 2.321

Review 5.  Missing heritability of common diseases and treatments outside the protein-coding exome.

Authors:  Wolfgang Sadee; Katherine Hartmann; Michał Seweryn; Maciej Pietrzak; Samuel K Handelman; Grzegorz A Rempala
Journal:  Hum Genet       Date:  2014-08-09       Impact factor: 4.132

6.  Genetically complex epilepsies, copy number variants and syndrome constellations.

Authors:  Heather C Mefford; John C Mulley
Journal:  Genome Med       Date:  2010-10-05       Impact factor: 11.117

7.  Unravelling genes and pathways implicated in working memory of schizophrenia in Han Chinese.

Authors:  Hongyan Ren; Chengcheng Zhang; Chaohua Huang; Na Li; Mingli Li; Yinfei Li; Wei Deng; Xiaohong Ma; Bo Xiang; Qiang Wang; Tao Li
Journal:  Int J Mol Sci       Date:  2015-01-20       Impact factor: 5.923

8.  Genome-wide search for exonic variants affecting translational efficiency.

Authors:  Quan Li; Angeliki Makri; Yang Lu; Luc Marchand; Rosemarie Grabs; Marylene Rousseau; Houria Ounissi-Benkalha; Jerry Pelletier; Francis Robert; Eef Harmsen; Thomas J Hudson; Tomi Pastinen; Constantin Polychronakos; Hui-Qi Qu
Journal:  Nat Commun       Date:  2013       Impact factor: 14.919

9.  Analyzing allele specific RNA expression using mixture models.

Authors:  Rong Lu; Ryan M Smith; Michal Seweryn; Danxin Wang; Katherine Hartmann; Amy Webb; Wolfgang Sadee; Grzegorz A Rempala
Journal:  BMC Genomics       Date:  2015-08-01       Impact factor: 3.969

10.  Association study between ZFHX3 gene polymorphisms and obesity in Korean population.

Authors:  Seung-Ae Yang
Journal:  J Exerc Rehabil       Date:  2017-08-29
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