Literature DB >> 20083436

The perils of PCR: can we accurately 'correct' antimalarial trials?

Jonathan J Juliano1, Nahla Gadalla, Colin J Sutherland, Steven R Meshnick.   

Abstract

During follow-up in antimalarial drug trials, treated subjects can be newly infected. PCR correction is used to distinguish this re-infection from drug failure (recrudescence) and to adjust final drug efficacy estimates. The epidemiological, biological and technical limitations of PCR correction and how this can lead to misclassification in drug trial outcomes are underappreciated. This article considers these limitations and proposes a framework for reporting, interpreting and improving PCR correction of antimalarial trials. Copyright 2010 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20083436      PMCID： PMC2844636          DOI： 10.1016/j.pt.2009.12.007

Source DB:  PubMed          Journal:  Trends Parasitol        ISSN： 1471-4922


  43 in total

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