Literature DB >> 19591576

Misclassification of drug failure in Plasmodium falciparum clinical trials in southeast Asia.

Jonathan J Juliano1, Frederic Ariey, Rithy Sem, Noppadon Tangpukdee, Srivicha Krudsood, Carol Olson, Sornchai Looareesuwan, William O Rogers, Chansuda Wongsrichanalai, Steven R Meshnick.   

Abstract

Most trials of antimalarials occur in areas in which reinfections are possible. For Plasmodium falciparum, reinfections are distinguished from recrudescences by polymerase chain reaction analysis of 3 polymorphic genes. However, the validity of this approach has never been rigorously tested. We tested for misclassification in 6 patients from clinical trials in Thailand and Cambodia who were classified as being reinfected by the standard polymerase chain reaction protocol. Using heteroduplex tracking assays and direct DNA sequencing, we found that 5 (83%) of 6 patients were misclassified. Misclassification in this manner overestimates the efficacy of antimalarials and delays the recognition of decreasing therapeutic efficacy, thus delaying potential changes in policy.

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Year:  2009        PMID： 19591576      PMCID： PMC2761972          DOI： 10.1086/600892

Source DB:  PubMed          Journal:  J Infect Dis        ISSN： 0022-1899            Impact factor:   5.226


  12 in total

1.  Estimating true antimalarial efficacy by heteroduplex tracking assay in patients with complex Plasmodium falciparum infections.

Authors:  Jesse J Kwiek; Alisa P Alker; Emily C Wenink; Marjorie Chaponda; Linda V Kalilani; Steven R Meshnick
Journal:  Antimicrob Agents Chemother       Date:  2006-11-20       Impact factor: 5.191

2.  Influence of consecutive-day blood sampling on polymerase chain reaction-adjusted parasitological cure rates in an antimalarial-drug trial conducted in Tanzania.

Authors:  Andreas Martensson; Billy Ngasala; Johan Ursing; M Isabel Veiga; Lisa Wiklund; Christopher Membi; Scott M Montgomery; Zul Premji; Anna Farnert; Anders Bjorkman
Journal:  J Infect Dis       Date:  2007-01-05       Impact factor: 5.226

3.  Measuring allelic heterogeneity in Plasmodium falciparum by a heteroduplex tracking assay.

Authors:  Warunee Ngrenngarmlert; Jesse J Kwiek; Deborah D Kamwendo; Kimberly Ritola; Ronald Swanstrom; Chansuda Wongsrichanalai; R Scott Miller; Wanida Ittarat; Steven R Meshnick
Journal:  Am J Trop Med Hyg       Date:  2005-06       Impact factor: 2.345

4.  Impact of transmission intensity on the accuracy of genotyping to distinguish recrudescence from new infection in antimalarial clinical trials.

Authors:  Bryan Greenhouse; Christian Dokomajilar; Alan Hubbard; Philip J Rosenthal; Grant Dorsey
Journal:  Antimicrob Agents Chemother       Date:  2007-06-25       Impact factor: 5.191

5.  Analysis of heterogeneous viral populations by direct DNA sequencing.

Authors:  T Leitner; E Halapi; G Scarlatti; P Rossi; J Albert; E M Fenyö; M Uhlén
Journal:  Biotechniques       Date:  1993-07       Impact factor: 1.993

6.  Plasmodium falciparum parasites in French Guiana: limited genetic diversity and high selfing rate.

Authors:  F Ariey; W Chalvet; D Hommel; C Peneau; A Hulin; O Mercereau-Puijalon; J B Duchemin; J L Sarthou; J M Reynes; T Fandeur
Journal:  Am J Trop Med Hyg       Date:  1999-12       Impact factor: 2.345

7.  Sequencing-based detection of low-frequency human immunodeficiency virus type 1 drug-resistant mutants by an RNA/DNA heteroduplex generator-tracking assay.

Authors:  Amit Kapoor; Morris Jones; R W Shafer; Soo-Yon Rhee; Powel Kazanjian; Eric L Delwart
Journal:  J Virol       Date:  2004-07       Impact factor: 5.103

8.  Plasmodium falciparum clonal population dynamics during malaria treatment.

Authors:  Sayeh Jafari; Jacques Le Bras; Olivier Bouchaud; Rémy Durand
Journal:  J Infect Dis       Date:  2004-01-08       Impact factor: 5.226

9.  Effects of Plasmodium falciparum mixed infections on in vitro antimalarial drug tests and genotyping.

Authors:  Shengfa Liu; Jianbing Mu; Hongying Jiang; Xin-zhuan Su
Journal:  Am J Trop Med Hyg       Date:  2008-08       Impact factor: 2.345

10.  A multiple-site-specific heteroduplex tracking assay as a tool for the study of viral population dynamics.

Authors:  W Resch; N Parkin; E L Stuelke; T Watkins; R Swanstrom
Journal:  Proc Natl Acad Sci U S A       Date:  2001-01-02       Impact factor: 11.205
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  16 in total

1.  Exposing malaria in-host diversity and estimating population diversity by capture-recapture using massively parallel pyrosequencing.

Authors:  Jonathan J Juliano; Kimberly Porter; Victor Mwapasa; Rithy Sem; William O Rogers; Frédéric Ariey; Chansuda Wongsrichanalai; Andrew Read; Steven R Meshnick
Journal:  Proc Natl Acad Sci U S A       Date:  2010-11-01       Impact factor: 11.205

2.  Adjusting for heterogeneity of malaria transmission in longitudinal studies.

Authors:  Teun Bousema; Benno Kreuels; Roly Gosling
Journal:  J Infect Dis       Date:  2011-07-01       Impact factor: 5.226

3.  Relevance of undetectably rare resistant malaria parasites in treatment failure: experimental evidence from Plasmodium chabaudi.

Authors:  Silvie Huijben; Brian H K Chan; Andrew F Read
Journal:  Am J Trop Med Hyg       Date:  2015-05-04       Impact factor: 2.345

4.  Uncertain outcomes: adjusting for misclassification in antimalarial efficacy studies.

Authors:  K A Porter; C L Burch; C Poole; J J Juliano; S R Cole; S R Meshnick
Journal:  Epidemiol Infect       Date:  2010-07-12       Impact factor: 2.451

5.  The perils of PCR: can we accurately 'correct' antimalarial trials?

Authors:  Jonathan J Juliano; Nahla Gadalla; Colin J Sutherland; Steven R Meshnick
Journal:  Trends Parasitol       Date:  2010-01-18

6.  Relapse or reinfection: Classification of malaria infection using transition likelihoods.

Authors:  Feng-Chang Lin; Quefeng Li; Jessica T Lin
Journal:  Biometrics       Date:  2020-03-03       Impact factor: 2.571

7.  Long term persistence of clonal malaria parasite Plasmodium falciparum lineages in the Colombian Pacific region.

Authors:  Diego F Echeverry; Shalini Nair; Lyda Osorio; Sanjay Menon; Claribel Murillo; Tim J C Anderson
Journal:  BMC Genet       Date:  2013-01-07       Impact factor: 2.797

8.  Evaluation of parasite subpopulations and genetic diversity of the msp1, msp2 and glurp genes during and following artesunate monotherapy treatment of Plasmodium falciparum malaria in Western Cambodia.

Authors:  Panita Gosi; Charlotte A Lanteri; Stuart D Tyner; Youry Se; Chanthap Lon; Michele Spring; Mengchuor Char; Darapiseth Sea; Sabaithip Sriwichai; Sittidech Surasri; Saowaluk Wongarunkochakorn; Kingkan Pidtana; Douglas S Walsh; Mark M Fukuda; Jessica Manning; David L Saunders; Delia Bethell
Journal:  Malar J       Date:  2013-11-09       Impact factor: 2.979

9.  Plasmodium falciparum drug resistance phenotype as assessed by patient antimalarial drug levels and its association with pfmdr1 polymorphisms.

Authors:  Maja Malmberg; Pedro E Ferreira; Joel Tarning; Johan Ursing; Billy Ngasala; Anders Björkman; Andreas Mårtensson; José P Gil
Journal:  J Infect Dis       Date:  2012-12-05       Impact factor: 5.226

10.  Residual Plasmodium falciparum parasitemia in Kenyan children after artemisinin-combination therapy is associated with increased transmission to mosquitoes and parasite recurrence.

Authors:  Khalid B Beshir; Colin J Sutherland; Patrick Sawa; Chris J Drakeley; Lucy Okell; Collins K Mweresa; Sabah A Omar; Seif A Shekalaghe; Harparkash Kaur; Arnold Ndaro; Jaffu Chilongola; Henk D F H Schallig; Robert W Sauerwein; Rachel L Hallett; Teun Bousema
Journal:  J Infect Dis       Date:  2013-08-14       Impact factor: 5.226
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