Literature DB >> 20066246

Ultralow power trapping and fluorescence detection of single particles on an optofluidic chip.

S Kühn1, B S Phillips, E J Lunt, A R Hawkins, H Schmidt.   

Abstract

The development of on-chip methods to manipulate particles is receiving rapidly increasing attention. All-optical traps offer numerous advantages, but are plagued by large required power levels on the order of hundreds of milliwatts and the inability to act exclusively on individual particles. Here, we demonstrate a fully integrated electro-optical trap for single particles with optical excitation power levels that are five orders of magnitude lower than in conventional optical force traps. The trap is based on spatio-temporal light modulation that is implemented using networks of antiresonant reflecting optical waveguides. We demonstrate the combination of on-chip trapping and fluorescence detection of single microorganisms by studying the photobleaching dynamics of stained DNA in E. coli bacteria. The favorable size scaling facilitates the trapping of single nanoparticles on integrated optofluidic chips.

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Year:  2009        PMID: 20066246      PMCID: PMC2863329          DOI: 10.1039/b915750f

Source DB:  PubMed          Journal:  Lab Chip        ISSN: 1473-0189            Impact factor:   6.799


  19 in total

1.  Fast low-cost digital lock-in.

Authors:  E Siefart
Journal:  Appl Opt       Date:  1977-05-01       Impact factor: 1.980

2.  Simultaneous, coincident optical trapping and single-molecule fluorescence.

Authors:  Matthew J Lang; Polly M Fordyce; Anita M Engh; Keir C Neuman; Steven M Block
Journal:  Nat Methods       Date:  2004-10-21       Impact factor: 28.547

3.  Massively parallel manipulation of single cells and microparticles using optical images.

Authors:  Pei Yu Chiou; Aaron T Ohta; Ming C Wu
Journal:  Nature       Date:  2005-07-21       Impact factor: 49.962

4.  Optical trapping.

Authors:  Keir C Neuman; Steven M Block
Journal:  Rev Sci Instrum       Date:  2004-09       Impact factor: 1.523

5.  Integrated monolithic optical manipulation.

Authors:  Simon Cran-McGreehin; Thomas F Krauss; Kishan Dholakia
Journal:  Lab Chip       Date:  2006-07-12       Impact factor: 6.799

6.  Suppressing Brownian motion of individual biomolecules in solution.

Authors:  Adam E Cohen; W E Moerner
Journal:  Proc Natl Acad Sci U S A       Date:  2006-03-14       Impact factor: 11.205

7.  Optofluidic trapping and transport on solid core waveguides within a microfluidic device.

Authors:  Bradley S Schmidt; Allen H Yang; David Erickson; Michal Lipson
Journal:  Opt Express       Date:  2007-10-29       Impact factor: 3.894

8.  Optofluidic waveguides: I. Concepts and implementations.

Authors:  Holger Schmidt; Aaron R Hawkins
Journal:  Microfluid Nanofluidics       Date:  2008-01-01       Impact factor: 2.529

9.  Optofluidic waveguides: II. Fabrication and structures.

Authors:  Aaron R Hawkins; Holger Schmidt
Journal:  Microfluid Nanofluidics       Date:  2007-07-19       Impact factor: 2.529

10.  Observation of a single-beam gradient force optical trap for dielectric particles.

Authors:  A Ashkin; J M Dziedzic; J E Bjorkholm; S Chu
Journal:  Opt Lett       Date:  1986-05-01       Impact factor: 3.776

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  15 in total

1.  Sampling techniques for single-cell electrophoresis.

Authors:  Christine Cecala; Jonathan V Sweedler
Journal:  Analyst       Date:  2012-01-30       Impact factor: 4.616

2.  Tailorable integrated optofluidic filters for biomolecular detection.

Authors:  Philip Measor; Brian S Phillips; Aiqing Chen; Aaron R Hawkins; Holger Schmidt
Journal:  Lab Chip       Date:  2011-01-10       Impact factor: 6.799

3.  Optofluidic bioanalysis: fundamentals and applications.

Authors:  Damla Ozcelik; Hong Cai; Kaelyn D Leake; Aaron R Hawkins; Holger Schmidt
Journal:  Nanophotonics       Date:  2017-03-16       Impact factor: 8.449

4.  Optofluidic Microsystems for Chemical and Biological Analysis.

Authors:  Xudong Fan; Ian M White
Journal:  Nat Photonics       Date:  2011-10-01       Impact factor: 38.771

5.  Spectrally reconfigurable integrated multi-spot particle trap.

Authors:  Kaelyn D Leake; Michael A B Olson; Damla Ozcelik; Aaron R Hawkins; Holger Schmidt
Journal:  Opt Lett       Date:  2015-12-01       Impact factor: 3.776

6.  A hyphenated optical trap capillary electrophoresis laser induced native fluorescence system for single-cell chemical analysis.

Authors:  Christine Cecala; Stanislav S Rubakhin; Jennifer W Mitchell; Martha U Gillette; Jonathan V Sweedler
Journal:  Analyst       Date:  2012-04-30       Impact factor: 4.616

7.  Signal-to-noise Enhancement in Optical Detection of Single Viruses with Multi-spot Excitation.

Authors:  Damla Ozcelik; Matthew A Stott; Joshua W Parks; Jennifer A Black; Thomas A Wall; Aaron R Hawkins; Holger Schmidt
Journal:  IEEE J Sel Top Quantum Electron       Date:  2016-03-21       Impact factor: 4.544

8.  Hybrid optofluidic integration.

Authors:  Joshua W Parks; Hong Cai; Lynnell Zempoaltecatl; Thomas D Yuzvinsky; Kaelyn Leake; Aaron R Hawkins; Holger Schmidt
Journal:  Lab Chip       Date:  2013-08-23       Impact factor: 6.799

9.  Optofluidic devices with integrated solid-state nanopores.

Authors:  Shuo Liu; Aaron R Hawkins; Holger Schmidt
Journal:  Mikrochim Acta       Date:  2016-01-27       Impact factor: 5.833

Review 10.  Recent advances in integrated solid-state nanopore sensors.

Authors:  Mahmudur Rahman; Mohammad Julker Neyen Sampad; Aaron Hawkins; Holger Schmidt
Journal:  Lab Chip       Date:  2021-06-17       Impact factor: 7.517

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