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Literature DB >> 27524876

Signal-to-noise Enhancement in Optical Detection of Single Viruses with Multi-spot Excitation.

Damla Ozcelik¹, Matthew A Stott², Joshua W Parks¹, Jennifer A Black¹, Thomas A Wall², Aaron R Hawkins², Holger Schmidt¹.

Abstract

We present fluorescence detection of single H1N1 viruses with enhanced signal to noise ratio (SNR) achieved by multi-spot excitation in liquid-core anti-resonant reflecting optical waveguides (ARROWs). Solid-core Y-splitting ARROW waveguides are fabricated orthogonal to the liquid-core section of the chip, creating multiple excitation spots for the analyte. We derive expressions for the SNR increase after signal processing, and analyze its dependence on signal levels and spot number. Very good agreement between theoretical calculations and experimental results is found. SNR enhancements up to 5x104 are demonstrated.

Entities: Chemical Disease Species

Keywords: Anti-resonant reflecting optical waveguides (ARROWs); Y-splitters; biophotonics; integrated waveguides; liquid core waveguides; optofluidics

Year: 2016 PMID： 27524876 PMCID： PMC4978512 DOI： 10.1109/JSTQE.2015.2503321

Source DB: PubMed Journal: IEEE J Sel Top Quantum Electron ISSN： 1077-260X Impact factor: 4.544

20 in total

Signal-to-noise Enhancement in Optical Detection of Single Viruses with Multi-spot Excitation.

1. Optofluidic wavelength division multiplexing for single-virus detection.

Review 2. Developing optofluidic technology through the fusion of microfluidics and optics.

3. Planar optofluidic chip for single particle detection, manipulation, and analysis.

4. Microphotonic control of single molecule fluorescence correlation spectroscopy using planar optofluidics.

5. Optofluidic waveguides: II. Fabrication and structures.

6. Integration of programmable microfluidics and on-chip fluorescence detection for biosensing applications.

7. Dual-core optofluidic chip for independent particle detection and tunable spectral filtering.

8. Ultrasensitive Qbeta phage analysis using fluorescence correlation spectroscopy on an optofluidic chip.

9. Time encoded multicolor fluorescence detection in a microfluidic flow cytometer.

10. Hybrid optofluidic integration.

1. Optimization of Y-splitting antiresonant reflecting optical waveguides-based rib waveguides.

2. Optimized ARROW-Based MMI Waveguides for High Fidelity Excitation Patterns for Optofluidic Multiplexing.

3. Multiplexed efficient on-chip sample preparation and sensitive amplification-free detection of Ebola virus.

4. Optofluidic bioanalysis: fundamentals and applications.

5. Free-Space Excitation of Optofluidic Devices for Pattern-Based Single Particle Detection.

6. Enhanced Detection of Single Viruses On-Chip via Hydrodynamic Focusing.

7. Optofluidic detection of Zika nucleic acid and protein biomarkers using multimode interference multiplexing.

8. 7X multiplexed, optofluidic detection of nucleic acids for antibiotic-resistance bacterial screening.

9. Optofluidic Lab-on-a-Chip Fluorescence Sensor Using Integrated Buried ARROW (bARROW) Waveguides.

10. Optofluidic Amplification-free Multiplex Detection of Viral Hemorrhagic Fevers.