Sebastian H Doeltgen1, Michael C Ridding. 1. The Robinson Institute, School of Paediatrics and Reproductive Health, University of Adelaide, Adelaide, Australia. sebastian.doeltgen@adelaide.edu.au
Abstract
OBJECTIVE: Behavioural exposure and sleep may bidirectionally modify the excitability of cortical networks including those in the motor cortex. Here we tested whether the excitability of intracortical inhibitory and excitatory networks within the primary motor cortex exhibited changes suggestive of a time of day influence. METHODS: Short-interval intracortical inhibition (SICI) and facilitation (ICF), and input-output curves (IO curves) were investigated using transcranial magnetic stimulation (TMS). Recordings were made from the resting right first dorsal interosseous (FDI) muscle in 10 healthy subjects on three occasions: 9A.M. and 4P.M. of the same day, and 9A.M. of the following day. RESULTS: There was no significant change in any of the measures across the three assessments. CONCLUSIONS: These findings provide evidence that time of day does not significantly influence corticospinal and intracortical excitability in the primary motor cortex. SIGNIFICANCE: These results provide no support for the hypothesis that synapses within the motor cortex undergo potentiation due to daytime use and behavioural experiences. Additionally, these findings provide evidence that measurement of motor cortical excitability is not systematically biased by time-of-day dependent variability and thus does not pose a confound in studies assessing corticospinal excitability longitudinally.
OBJECTIVE: Behavioural exposure and sleep may bidirectionally modify the excitability of cortical networks including those in the motor cortex. Here we tested whether the excitability of intracortical inhibitory and excitatory networks within the primary motor cortex exhibited changes suggestive of a time of day influence. METHODS: Short-interval intracortical inhibition (SICI) and facilitation (ICF), and input-output curves (IO curves) were investigated using transcranial magnetic stimulation (TMS). Recordings were made from the resting right first dorsal interosseous (FDI) muscle in 10 healthy subjects on three occasions: 9A.M. and 4P.M. of the same day, and 9A.M. of the following day. RESULTS: There was no significant change in any of the measures across the three assessments. CONCLUSIONS: These findings provide evidence that time of day does not significantly influence corticospinal and intracortical excitability in the primary motor cortex. SIGNIFICANCE: These results provide no support for the hypothesis that synapses within the motor cortex undergo potentiation due to daytime use and behavioural experiences. Additionally, these findings provide evidence that measurement of motor cortical excitability is not systematically biased by time-of-day dependent variability and thus does not pose a confound in studies assessing corticospinal excitability longitudinally.
Authors: Daniel A Cohen; Catarina Freitas; Jose Maria Tormos; Lindsay Oberman; Mark Eldaief; Alvaro Pascual-Leone Journal: Clin Neurophysiol Date: 2010-06-11 Impact factor: 3.708
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