OBJECTIVE: Previous work has demonstrated that corticospinal facilitation from 20Hz repetitive transcranial magnetic stimulation (rTMS) was greater during a second rTMS session 24h after the first. We sought to determine whether such metaplasticity is dependent on a particular phase of the normal sleep-wake/circadian cycle. METHODS: Twenty healthy participants received two sessions of 20Hz rTMS over the hand motor cortex (M1) spaced 12h apart, either over-day or overnight. RESULTS: Baseline corticospinal excitability did not differ by group or session. The time-of-day of Session 1 did not influence the relative increase in excitability following rTMS. However, the increase in excitability from the second rTMS session was 2-fold greater in the overnight group. CONCLUSIONS: When a night with sleep follows rTMS to M1, the capacity to induce subsequent plasticity in M1 is enhanced, suggesting sleep-wake and/or circadian-dependent modulation of processes of metaplasticity. SIGNIFICANCE: TMS treatment of neuropsychiatric disorders entails repeated sessions of rTMS. Our findings suggest that the timing of sessions relative to the sleep-wake/circadian cycle may be a critical factor in the cumulative effect of treatment. Future studies using this paradigm may provide mechanistic insights into human metaplasticity, leading to refined strategies to enhance non-invasive stimulation therapies.
OBJECTIVE: Previous work has demonstrated that corticospinal facilitation from 20Hz repetitive transcranial magnetic stimulation (rTMS) was greater during a second rTMS session 24h after the first. We sought to determine whether such metaplasticity is dependent on a particular phase of the normal sleep-wake/circadian cycle. METHODS: Twenty healthy participants received two sessions of 20Hz rTMS over the hand motor cortex (M1) spaced 12h apart, either over-day or overnight. RESULTS: Baseline corticospinal excitability did not differ by group or session. The time-of-day of Session 1 did not influence the relative increase in excitability following rTMS. However, the increase in excitability from the second rTMS session was 2-fold greater in the overnight group. CONCLUSIONS: When a night with sleep follows rTMS to M1, the capacity to induce subsequent plasticity in M1 is enhanced, suggesting sleep-wake and/or circadian-dependent modulation of processes of metaplasticity. SIGNIFICANCE: TMS treatment of neuropsychiatric disorders entails repeated sessions of rTMS. Our findings suggest that the timing of sessions relative to the sleep-wake/circadian cycle may be a critical factor in the cumulative effect of treatment. Future studies using this paradigm may provide mechanistic insights into human metaplasticity, leading to refined strategies to enhance non-invasive stimulation therapies.
Authors: C A Czeisler; J F Duffy; T L Shanahan; E N Brown; J F Mitchell; D W Rimmer; J M Ronda; E J Silva; J S Allan; J S Emens; D J Dijk; R E Kronauer Journal: Science Date: 1999-06-25 Impact factor: 47.728
Authors: Philippe Peigneux; Steven Laureys; Sonia Fuchs; Fabienne Collette; Fabien Perrin; Jean Reggers; Christophe Phillips; Christian Degueldre; Guy Del Fiore; Joël Aerts; André Luxen; Pierre Maquet Journal: Neuron Date: 2004-10-28 Impact factor: 17.173
Authors: Luigi De Gennaro; Fabiana Fratello; Cristina Marzano; Fabio Moroni; Giuseppe Curcio; Daniela Tempesta; Maria Concetta Pellicciari; Cornelia Pirulli; Michele Ferrara; Paolo Maria Rossini Journal: PLoS One Date: 2008-06-25 Impact factor: 3.240