Literature DB >> 20060279

The innate immune response in leprosy.

Robert L Modlin1.   

Abstract

Investigation into the innate immune response in leprosy has provided insight into immunoregulation in human infectious disease. Key advances include the role of pattern recognition receptors in recognizing pathogen-associated molecular patterns of Mycobacterium leprae, cytokine release by innate immune cells, macrophage and dendritic cell differentiation, as well as antimicrobial effector pathways. These insights provide targets for therapeutic intervention in modulating the course of leprosy and other chronic infectious diseases. Copyright 2009 Elsevier Ltd. All rights reserved.

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Year:  2010        PMID： 20060279      PMCID： PMC2882026          DOI： 10.1016/j.coi.2009.12.001

Source DB:  PubMed          Journal:  Curr Opin Immunol        ISSN： 0952-7915            Impact factor:   7.486


  88 in total

1.  Large-scale candidate gene study of leprosy susceptibility in the Karonga district of northern Malawi.

Authors:  Jodene Fitness; Sian Floyd; David K Warndorff; Lifted Sichali; Lorren Mwaungulu; Amelia C Crampin; Paul E M Fine; Adrian V S Hill
Journal:  Am J Trop Med Hyg       Date:  2004-09       Impact factor: 2.345

2.  Expression of Toll-like receptor 2 on human Schwann cells: a mechanism of nerve damage in leprosy.

Authors:  Rosane B Oliveira; Maria T Ochoa; Peter A Sieling; Thomas H Rea; Anura Rambukkana; Euzenir N Sarno; Robert L Modlin
Journal:  Infect Immun       Date:  2003-03       Impact factor: 3.441

3.  Cutting edge: a Toll-like receptor 2 polymorphism that is associated with lepromatous leprosy is unable to mediate mycobacterial signaling.

Authors:  Pierre-Yves Bochud; Thomas R Hawn; Alan Aderem
Journal:  J Immunol       Date:  2003-04-01       Impact factor: 5.422

4.  Divergence of macrophage phagocytic and antimicrobial programs in leprosy.

Authors:  Dennis Montoya; Daniel Cruz; Rosane M B Teles; Delphine J Lee; Maria Teresa Ochoa; Stephan R Krutzik; Rene Chun; Mirjam Schenk; Xiaoran Zhang; Benjamin G Ferguson; Anne E Burdick; Euzenir N Sarno; Thomas H Rea; Martin Hewison; John S Adams; Genhong Cheng; Robert L Modlin
Journal:  Cell Host Microbe       Date:  2009-10-22       Impact factor: 21.023

5.  CD1 expression by dendritic cells in human leprosy lesions: correlation with effective host immunity.

Authors:  P A Sieling; D Jullien; M Dahlem; T F Tedder; T H Rea; R L Modlin; S A Porcelli
Journal:  J Immunol       Date:  1999-02-01       Impact factor: 5.422

6.  Interleukin-10 promoter single-nucleotide polymorphisms as markers for disease susceptibility and disease severity in leprosy.

Authors:  M O Moraes; A G Pacheco; J J M Schonkeren; P R Vanderborght; J A C Nery; A R Santos; M E Moraes; J R Moraes; T H M Ottenhoff; E P Sampaio; T W J Huizinga; E N Sarno
Journal:  Genes Immun       Date:  2004-11       Impact factor: 2.676

7.  Nod2 is a general sensor of peptidoglycan through muramyl dipeptide (MDP) detection.

Authors:  Stephen E Girardin; Ivo G Boneca; Jérôme Viala; Mathias Chamaillard; Agnès Labigne; Gilles Thomas; Dana J Philpott; Philippe J Sansonetti
Journal:  J Biol Chem       Date:  2003-01-13       Impact factor: 5.157

8.  IFN-gamma- and TNF-independent vitamin D-inducible human suppression of mycobacteria: the role of cathelicidin LL-37.

Authors:  Adrian R Martineau; Katalin A Wilkinson; Sandra M Newton; R Andres Floto; Anthony W Norman; Keira Skolimowska; Robert N Davidson; Ole E Sørensen; Beate Kampmann; Christopher J Griffiths; Robert J Wilkinson
Journal:  J Immunol       Date:  2007-06-01       Impact factor: 5.422

9.  MARCO, TLR2, and CD14 are required for macrophage cytokine responses to mycobacterial trehalose dimycolate and Mycobacterium tuberculosis.

Authors:  Dawn M E Bowdish; Kaori Sakamoto; Mi-Jeong Kim; Mariliis Kroos; Subhankar Mukhopadhyay; Cynthia A Leifer; Karl Tryggvason; Siamon Gordon; David G Russell
Journal:  PLoS Pathog       Date:  2009-06-12       Impact factor: 6.823

10.  Regulation of dendritic cell migration to the draining lymph node: impact on T lymphocyte traffic and priming.

Authors:  Alfonso MartIn-Fontecha; Silvia Sebastiani; Uta E Höpken; Mariagrazia Uguccioni; Martin Lipp; Antonio Lanzavecchia; Federica Sallusto
Journal:  J Exp Med       Date:  2003-08-18       Impact factor: 14.307
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  39 in total

1.  Genetic variants of the MRC1 gene and the IFNG gene are associated with leprosy in Han Chinese from Southwest China.

Authors:  Dong Wang; Jia-Qi Feng; Yu-Ye Li; Deng-Feng Zhang; Xiao-An Li; Qing-Wei Li; Yong-Gang Yao
Journal:  Hum Genet       Date:  2012-03-06       Impact factor: 4.132

2.  Mechanisms of tumor necrosis factor α antagonist-induced lupus in a murine model.

Authors:  Yuan Xu; Haoyang Zhuang; Shuhong Han; Chao Liu; Hai Wang; Clayton E Mathews; John Massini; Lijun Yang; Westley H Reeves
Journal:  Arthritis Rheumatol       Date:  2015-01       Impact factor: 10.995

3.  Missense Variants in HIF1A and LACC1 Contribute to Leprosy Risk in Han Chinese.

Authors:  Dong Wang; Yu Fan; Mahadev Malhi; Rui Bi; Yong Wu; Min Xu; Xiu-Feng Yu; Heng Long; Yu-Ye Li; Deng-Feng Zhang; Yong-Gang Yao
Journal:  Am J Hum Genet       Date:  2018-04-26       Impact factor: 11.025

4.  Association of TNF, MBL, and VDR polymorphisms with leprosy phenotypes.

Authors:  Bishwa R Sapkota; Murdo Macdonald; William R Berrington; E Ann Misch; Chaman Ranjit; M Ruby Siddiqui; Gilla Kaplan; Thomas R Hawn
Journal:  Hum Immunol       Date:  2010-08-01       Impact factor: 2.850

Review 5.  Leprosy and the human genome.

Authors:  Elizabeth A Misch; William R Berrington; James C Vary; Thomas R Hawn
Journal:  Microbiol Mol Biol Rev       Date:  2010-12       Impact factor: 11.056

6.  Live Mycobacterium leprae inhibits autophagy and apoptosis of infected macrophages and prevents engulfment of host cell by phagocytes.

Authors:  Yuelong Ma; Qin Pei; Li Zhang; Jie Lu; Tiejun Shui; Jia Chen; Chao Shi; Jun Yang; Michael Smith; Yeqiang Liu; Jianyu Zhu; Degang Yang
Journal:  Am J Transl Res       Date:  2018-09-15       Impact factor: 4.060

7.  Galectin-3 regulates the innate immune response of human monocytes.

Authors:  Andrew W Chung; Peter A Sieling; Mirjam Schenk; Rosane M B Teles; Stephan R Krutzik; Daniel K Hsu; Fu-Tong Liu; Euzenir N Sarno; Thomas H Rea; Steffen Stenger; Robert L Modlin; Delphine J Lee
Journal:  J Infect Dis       Date:  2012-12-18       Impact factor: 5.226

8.  Genetic variants of complement genes ficolin-2, mannose-binding lectin and complement factor H are associated with leprosy in Han Chinese from Southwest China.

Authors:  Deng-Feng Zhang; Xian-Qiong Huang; Dong Wang; Yu-Ye Li; Yong-Gang Yao
Journal:  Hum Genet       Date:  2013-02-20       Impact factor: 4.132

Review 9.  Gene Association with Leprosy: A Review of Published Data.

Authors:  Priscila Saamara Mazini; Hugo Vicentin Alves; Pâmela Guimarães Reis; Ana Paula Lopes; Ana Maria Sell; Manuel Santos-Rosa; Jeane Eliete Laguila Visentainer; Paulo Rodrigues-Santos
Journal:  Front Immunol       Date:  2016-01-12       Impact factor: 7.561

10.  Relationship Between sCD163 and mCD163 and Their Implication in the Detection and Typing of Leprosy.

Authors:  Azza Gaber Antar Farag; Shymaa A El Askary; Waleed M Fathy; Fathia Elbassal; Ayman Ali Azzam; Nermin Reda Tayel; Samah Saad Abdul Karim; Wafaa Ahmed Shehata
Journal:  Clin Cosmet Investig Dermatol       Date:  2020-06-02
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