| Literature DB >> 19837374 |
Dennis Montoya1, Daniel Cruz, Rosane M B Teles, Delphine J Lee, Maria Teresa Ochoa, Stephan R Krutzik, Rene Chun, Mirjam Schenk, Xiaoran Zhang, Benjamin G Ferguson, Anne E Burdick, Euzenir N Sarno, Thomas H Rea, Martin Hewison, John S Adams, Genhong Cheng, Robert L Modlin.
Abstract
Effective innate immunity against many microbial pathogens requires macrophage programs that upregulate phagocytosis and direct antimicrobial pathways, two functions generally assumed to be coordinately regulated. We investigated the regulation of these key functions in human blood-derived macrophages. Interleukin-10 (IL-10) induced the phagocytic pathway, including the C-type lectin CD209 and scavenger receptors, resulting in phagocytosis of mycobacteria and oxidized low-density lipoprotein. IL-15 induced the vitamin D-dependent antimicrobial pathway and CD209, yet the cells were less phagocytic. The differential regulation of macrophage functional programs was confirmed by analysis of leprosy lesions: the macrophage phagocytosis pathway was prominent in the clinically progressive, multibacillary form of the disease, whereas the vitamin D-dependent antimicrobial pathway predominated in the self-limited form and in patients undergoing reversal reactions from the multibacillary to the self-limited form. These data indicate that macrophage programs for phagocytosis and antimicrobial responses are distinct and differentially regulated in innate immunity to bacterial infections.Entities:
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Year: 2009 PMID： 19837374 PMCID： PMC2764558 DOI： 10.1016/j.chom.2009.09.002
Source DB: PubMed Journal: Cell Host Microbe ISSN： 1931-3128 Impact factor: 21.023