Literature DB >> 20059945

Outsmarting a mastermind.

Katherine A Jones1.   

Abstract

Moellering et al. recently reported that a cell-permeable "stapled" synthetic peptide of the Notch coactivator Mastermind is a potent dominant-negative inhibitor of oncogenic Notch signaling in T cell acute lymphoblastic leukemia. This new class of inhibitor may find broad utility in blocking protein-protein interactions that underlie many human diseases. 2009 Elsevier Inc. All rights reserved.

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Year:  2009        PMID： 20059945      PMCID： PMC2810139          DOI： 10.1016/j.devcel.2009.12.002

Source DB:  PubMed          Journal:  Dev Cell        ISSN： 1534-5807            Impact factor:   12.270


  10 in total

1.  Notch/gamma-secretase inhibition turns proliferative cells in intestinal crypts and adenomas into goblet cells.

Authors:  Johan H van Es; Marielle E van Gijn; Orbicia Riccio; Maaike van den Born; Marc Vooijs; Harry Begthel; Miranda Cozijnsen; Sylvie Robine; Doug J Winton; Freddy Radtke; Hans Clevers
Journal:  Nature       Date:  2005-06-16       Impact factor: 49.962

2.  CDK8 is a stimulus-specific positive coregulator of p53 target genes.

Authors:  Aaron Joseph Donner; Stephanie Szostek; Jennifer Michelle Hoover; Joaquin Maximiliano Espinosa
Journal:  Mol Cell       Date:  2007-07-06       Impact factor: 17.970

Review 3.  Transcriptional mechanisms by the coregulator MAML1.

Authors:  M Saint Just Ribeiro; A E Wallberg
Journal:  Curr Protein Pept Sci       Date:  2009-12       Impact factor: 3.272

4.  Nipped-A, the Tra1/TRRAP subunit of the Drosophila SAGA and Tip60 complexes, has multiple roles in Notch signaling during wing development.

Authors:  Maria Gause; Joel C Eissenberg; Amy F Macrae; Maia Dorsett; Ziva Misulovin; Dale Dorsett
Journal:  Mol Cell Biol       Date:  2006-03       Impact factor: 4.272

5.  Direct inhibition of the NOTCH transcription factor complex.

Authors:  Raymond E Moellering; Melanie Cornejo; Tina N Davis; Cristina Del Bianco; Jon C Aster; Stephen C Blacklow; Andrew L Kung; D Gary Gilliland; Gregory L Verdine; James E Bradner
Journal:  Nature       Date:  2009-11-12       Impact factor: 49.962

6.  Structural basis for cooperativity in recruitment of MAML coactivators to Notch transcription complexes.

Authors:  Yunsun Nam; Piotr Sliz; Luyan Song; Jon C Aster; Stephen C Blacklow
Journal:  Cell       Date:  2006-03-10       Impact factor: 41.582

Review 7.  Notch signaling in leukemia.

Authors:  Jon C Aster; Warren S Pear; Stephen C Blacklow
Journal:  Annu Rev Pathol       Date:  2008       Impact factor: 23.472

8.  Promoter-specific co-activation by Drosophila mastermind.

Authors:  John W Cave; Michael A Caudy
Journal:  Biochem Biophys Res Commun       Date:  2008-10-16       Impact factor: 3.575

Review 9.  Revving the Throttle on an oncogene: CDK8 takes the driver seat.

Authors:  Ron Firestein; William C Hahn
Journal:  Cancer Res       Date:  2009-10-06       Impact factor: 12.701

10.  Notch activation stimulates transient and selective binding of Su(H)/CSL to target enhancers.

Authors:  Alena Krejcí; Sarah Bray
Journal:  Genes Dev       Date:  2007-06-01       Impact factor: 11.361
  10 in total
  3 in total

1.  Notch-mediated patterning and cell fate allocation of pancreatic progenitor cells.

Authors:  Solomon Afelik; Xiaoling Qu; Edy Hasrouni; Michael A Bukys; Tye Deering; Stephan Nieuwoudt; William Rogers; Raymond J Macdonald; Jan Jensen
Journal:  Development       Date:  2012-03-29       Impact factor: 6.868

2.  Notch signaling promotes osteoclast maturation and resorptive activity.

Authors:  Jason W Ashley; Jaimo Ahn; Kurt D Hankenson
Journal:  J Cell Biochem       Date:  2015-11       Impact factor: 4.429

Review 3.  Objective assessment of cancer genes for drug discovery.

Authors:  Mishal N Patel; Mark D Halling-Brown; Joseph E Tym; Paul Workman; Bissan Al-Lazikani
Journal:  Nat Rev Drug Discov       Date:  2013-01       Impact factor: 84.694
  3 in total

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