Literature DB >> 18039126

Notch signaling in leukemia.

Jon C Aster1, Warren S Pear, Stephen C Blacklow.   

Abstract

Recent discoveries indicate that gain-of-function mutations in the Notch1 receptor are very common in human T cell acute lymphoblastic leukemia/lymphoma. This review discusses what these mutations have taught us about normal and pathophysiologic Notch1 signaling, and how these insights may lead to new targeted therapies for patients with this aggressive form of cancer.

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Year:  2008        PMID： 18039126      PMCID： PMC5934586          DOI： 10.1146/annurev.pathmechdis.3.121806.154300

Source DB:  PubMed          Journal:  Annu Rev Pathol        ISSN： 1553-4006            Impact factor:   23.472


  145 in total

1.  Discrete enhancer elements mediate selective responsiveness of enhancer of split complex genes to common transcriptional activators.

Authors:  D T Nellesen; E C Lai; J W Posakony
Journal:  Dev Biol       Date:  1999-09-01       Impact factor: 3.582

2.  Regulation of B versus T lymphoid lineage fate decision by the proto-oncogene LRF.

Authors:  Takahiro Maeda; Taha Merghoub; Robin M Hobbs; Lin Dong; Manami Maeda; Johannes Zakrzewski; Marcel R M van den Brink; Arthur Zelent; Hirokazu Shigematsu; Koichi Akashi; Julie Teruya-Feldstein; Giorgio Cattoretti; Pier Paolo Pandolfi
Journal:  Science       Date:  2007-05-11       Impact factor: 47.728

3.  Nicastrin modulates presenilin-mediated notch/glp-1 signal transduction and betaAPP processing.

Authors:  G Yu; M Nishimura; S Arawaka; D Levitan; L Zhang; A Tandon; Y Q Song; E Rogaeva; F Chen; T Kawarai; A Supala; L Levesque; H Yu; D S Yang; E Holmes; P Milman; Y Liang; D M Zhang; D H Xu; C Sato; E Rogaev; M Smith; C Janus; Y Zhang; R Aebersold; L S Farrer; S Sorbi; A Bruni; P Fraser; P St George-Hyslop
Journal:  Nature       Date:  2000-09-07       Impact factor: 49.962

4.  Intracellular cleavage of Notch leads to a heterodimeric receptor on the plasma membrane.

Authors:  C M Blaumueller; H Qi; P Zagouras; S Artavanis-Tsakonas
Journal:  Cell       Date:  1997-07-25       Impact factor: 41.582

5.  NF-kappaB2 is a putative target gene of activated Notch-1 via RBP-Jkappa.

Authors:  F Oswald; S Liptay; G Adler; R M Schmid
Journal:  Mol Cell Biol       Date:  1998-04       Impact factor: 4.272

6.  Pre-TCR-triggered ERK signalling-dependent downregulation of E2A activity in Notch3-induced T-cell lymphoma.

Authors:  Claudio Talora; Antonio F Campese; Diana Bellavia; Monica Pascucci; Saula Checquolo; Manuela Groppioni; Luigi Frati; Harald von Boehmer; Alberto Gulino; Isabella Screpanti
Journal:  EMBO Rep       Date:  2003-10-17       Impact factor: 8.807

7.  Mastermind critically regulates Notch-mediated lymphoid cell fate decisions.

Authors:  Ivan Maillard; Andrew P Weng; Andrea C Carpenter; Carlos G Rodriguez; Hong Sai; Lanwei Xu; David Allman; Jon C Aster; Warren S Pear
Journal:  Blood       Date:  2004-06-08       Impact factor: 22.113

8.  Signalling downstream of activated mammalian Notch.

Authors:  S Jarriault; C Brou; F Logeat; E H Schroeter; R Kopan; A Israel
Journal:  Nature       Date:  1995-09-28       Impact factor: 49.962

9.  Mastermind recruits CycC:CDK8 to phosphorylate the Notch ICD and coordinate activation with turnover.

Authors:  Christy J Fryer; J Brandon White; Katherine A Jones
Journal:  Mol Cell       Date:  2004-11-19       Impact factor: 17.970

10.  Separation of Notch1 promoted lineage commitment and expansion/transformation in developing T cells.

Authors:  D Allman; F G Karnell; J A Punt; S Bakkour; L Xu; P Myung; G A Koretzky; J C Pui; J C Aster; W S Pear
Journal:  J Exp Med       Date:  2001-07-02       Impact factor: 14.307
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  130 in total

1.  Deletion-based mechanisms of Notch1 activation in T-ALL: key roles for RAG recombinase and a conserved internal translational start site in Notch1.

Authors:  Todd D Ashworth; Warren S Pear; Mark Y Chiang; Stephen C Blacklow; Jérôme Mastio; Lanwei Xu; Michelle Kelliher; Philippe Kastner; Susan Chan; Jon C Aster
Journal:  Blood       Date:  2010-09-17       Impact factor: 22.113

Review 2.  Non-canonical activation of Notch signaling/target genes in vertebrates.

Authors:  Rajendran Sanalkumar; Sivadasan Bindu Dhanesh; Jackson James
Journal:  Cell Mol Life Sci       Date:  2010-05-11       Impact factor: 9.261

Review 3.  The double-edged sword of Notch signaling in cancer.

Authors:  Andrew P South; Raymond J Cho; Jon C Aster
Journal:  Semin Cell Dev Biol       Date:  2012-01-30       Impact factor: 7.727

Review 4.  Expanding role of delta-like 4 mediated notch signaling in cardiovascular and metabolic diseases.

Authors:  Daiju Fukuda; Masanori Aikawa
Journal:  Circ J       Date:  2013-09-12       Impact factor: 2.993

5.  Mature human eosinophils express functional Notch ligands mediating eosinophil autocrine regulation.

Authors:  Amy L Radke; Lauren E Reynolds; Rossana C N Melo; Ann M Dvorak; Peter F Weller; Lisa A Spencer
Journal:  Blood       Date:  2009-01-26       Impact factor: 22.113

Review 6.  The role of NOTCH1 signaling in T-ALL.

Authors:  Adolfo A Ferrando
Journal:  Hematology Am Soc Hematol Educ Program       Date:  2009

7.  Alterations of the Notch pathway in lung cancer.

Authors:  Britta Westhoff; Ivan N Colaluca; Giovanni D'Ario; Maddalena Donzelli; Daniela Tosoni; Sara Volorio; Giuseppe Pelosi; Lorenzo Spaggiari; Giovanni Mazzarol; Giuseppe Viale; Salvatore Pece; Pier Paolo Di Fiore
Journal:  Proc Natl Acad Sci U S A       Date:  2009-12-10       Impact factor: 11.205

8.  Acute T-cell leukemias remain dependent on Notch signaling despite PTEN and INK4A/ARF loss.

Authors:  Hind Medyouf; Xiuhua Gao; Florence Armstrong; Samuel Gusscott; Qing Liu; Amanda Larson Gedman; Larry H Matherly; Kirk R Schultz; Francoise Pflumio; Mingjian James You; Andrew P Weng
Journal:  Blood       Date:  2009-12-11       Impact factor: 22.113

Review 9.  Mechanisms and clinical prospects of Notch inhibitors in the therapy of hematological malignancies.

Authors:  Yulia Nefedova; Dmitry Gabrilovich
Journal:  Drug Resist Updat       Date:  2008-10-31       Impact factor: 18.500

10.  Heterozygosity for hypoxia inducible factor 1alpha decreases the incidence of thymic lymphomas in a p53 mutant mouse model.

Authors:  Jessica A Bertout; Shetal A Patel; Benjamin H Fryer; Amy C Durham; Kelly L Covello; Kenneth P Olive; Michael H Goldschmidt; M Celeste Simon
Journal:  Cancer Res       Date:  2009-03-17       Impact factor: 12.701
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