Literature DB >> 20053565

Synthesis and antimicrobial activity of 2-fluorophenyl-4,6-disubstituted [1,3,5]triazines.

Mona Saleh1, Shaun Abbott, Valérie Perron, Caroline Lauzon, Christopher Penney, Boulos Zacharie.   

Abstract

A series of 2-fluorophenyl-4,6-disubstituted [1,3,5]triazines (1) and (2) were synthesized and evaluated for their antimicrobial activity against three representative gram-positive bacteria and two fungi. The structure-activity relationship (SAR) demonstrates that the 3- or 4-fluorophenyl component attached directly to the triazine ring was essential for activity. Of these compounds, 14, 15, and 25 demonstrated significant activity against all selected organisms compared to control. These compounds were generally nontoxic and may prove useful as antimicrobial agents. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 20053565     DOI： 10.1016/j.bmcl.2009.12.063

Source DB:  PubMed          Journal:  Bioorg Med Chem Lett        ISSN： 0960-894X            Impact factor:   2.823


  8 in total

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6.  Atom-efficient synthesis of 2,4,6-trisubstituted 1,3,5-triazines via Fe-catalyzed cyclization of aldehydes with NH4I as the sole nitrogen source.

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7.  Synthesis of New 1,3,5-Triazine-Based 2-Pyrazolines as Potential Anticancer Agents.

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8.  Design and Synthesis of New 1,3,5-Trisubstituted Triazines for the Treatment of Cancer and Inflammation.

Authors:  Boulos Zacharie; Shaun D Abbott; Jean-Simon Duceppe; Lyne Gagnon; Brigitte Grouix; Lilianne Geerts; Liette Gervais; François Sarra-Bournet; Valérie Perron; Nicole Wilb; Christopher L Penney; Pierre Laurin
Journal:  ChemistryOpen       Date:  2018-09-21       Impact factor: 2.911
  8 in total

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