Literature DB >> 20048367

Genetic testing for Alzheimer's and long-term care insurance.

Donald H Taylor1, Robert M Cook-Deegan, Susan Hiraki, J Scott Roberts, Dan G Blazer, Robert C Green.   

Abstract

A genetic marker known as apolipoprotein E provides a clear signal of a person's risk of developing Alzheimer's disease and thus that person's future need for long-term care. People who find that they have the variant of the trait that increases Alzheimer's disease risk are more likely to purchase long-term care insurance after receiving this information. If the information is widely introduced into the insurance market, coverage rates could be affected in different ways, depending on who possesses that information. Policymakers will eventually need to confront the issue of the use of this and other markers in the pricing of long-term care insurance.

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Year:  2010        PMID: 20048367      PMCID: PMC2931337          DOI: 10.1377/hlthaff.2009.0525

Source DB:  PubMed          Journal:  Health Aff (Millwood)        ISSN: 0278-2715            Impact factor:   9.048


  16 in total

1.  The relative effect of Alzheimer's disease and related dementias, disability, and comorbidities on cost of care for elderly persons.

Authors:  D H Taylor; M Schenkman; J Zhou; F A Sloan
Journal:  J Gerontol B Psychol Sci Soc Sci       Date:  2001-09       Impact factor: 4.077

2.  A test for the insurance industry.

Authors:  R J Pokorski
Journal:  Nature       Date:  1998-02-26       Impact factor: 49.962

3.  Dynamic Inefficiencies in Insurance Markets: Evidence from Long-Term Care Insurance.

Authors:  Amy Finkelstein; Kathleen McGarry; Amir Sufi
Journal:  Am Econ Rev       Date:  2005-05

4.  National estimates of the quantity and cost of informal caregiving for the elderly with dementia.

Authors:  K M Langa; M E Chernew; M U Kabeto; A R Herzog; M B Ofstedal; R J Willis; R B Wallace; L M Mucha; W L Straus; A M Fendrick
Journal:  J Gen Intern Med       Date:  2001-11       Impact factor: 5.128

5.  The cost of institutional care in Alzheimer's disease: nursing home and hospital use in a prospective cohort.

Authors:  H G Welch; J S Walsh; E B Larson
Journal:  J Am Geriatr Soc       Date:  1992-03       Impact factor: 5.562

6.  APOE epsilon4 and low cholesterol as risks for depression in a biracial elderly community sample.

Authors:  Dan G Blazer; Bruce B Burchett; Gerda G Fillenbaum
Journal:  Am J Geriatr Psychiatry       Date:  2002 Sep-Oct       Impact factor: 4.105

7.  Reasons for seeking genetic susceptibility testing among first-degree relatives of people with Alzheimer disease.

Authors:  J Scott Roberts; Susan A LaRusse; Heather Katzen; Peter J Whitehouse; Melissa Barber; Stephen G Post; Norman Relkin; Kimberly Quaid; Robert H Pietrzak; L Adrienne Cupples; Lindsay A Farrer; Tamsen Brown; Robert C Green
Journal:  Alzheimer Dis Assoc Disord       Date:  2003 Apr-Jun       Impact factor: 2.703

8.  Effects of age, sex, and ethnicity on the association between apolipoprotein E genotype and Alzheimer disease. A meta-analysis. APOE and Alzheimer Disease Meta Analysis Consortium.

Authors:  L A Farrer; L A Cupples; J L Haines; B Hyman; W A Kukull; R Mayeux; R H Myers; M A Pericak-Vance; N Risch; C M van Duijn
Journal:  JAMA       Date:  1997 Oct 22-29       Impact factor: 56.272

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  24 in total

1.  Prenatal whole genome sequencing: just because we can, should we?

Authors:  Greer Donley; Sara Chandros Hull; Benjamin E Berkman
Journal:  Hastings Cent Rep       Date:  2012-06-20       Impact factor: 2.683

Review 2.  Communicating genetic risk information for common disorders in the era of genomic medicine.

Authors:  Denise M Lautenbach; Kurt D Christensen; Jeffrey A Sparks; Robert C Green
Journal:  Annu Rev Genomics Hum Genet       Date:  2013       Impact factor: 8.929

Review 3.  The future of direct-to-consumer clinical genetic tests.

Authors:  Felix W Frueh; Henry T Greely; Robert C Green; Stuart Hogarth; Sue Siegel
Journal:  Nat Rev Genet       Date:  2011-06-01       Impact factor: 53.242

Review 4.  Expert consensus document: Mind the gaps—advancing research into short-term and long-term neuropsychological outcomes of youth sports-related concussions.

Authors:  Aaron J Carman; Rennie Ferguson; Robert Cantu; R Dawn Comstock; Penny A Dacks; Steven T DeKosky; Sam Gandy; James Gilbert; Chad Gilliland; Gerard Gioia; Christopher Giza; Michael Greicius; Brian Hainline; Ronald L Hayes; James Hendrix; Barry Jordan; James Kovach; Rachel F Lane; Rebekah Mannix; Thomas Murray; Tad Seifert; Diana W Shineman; Eric Warren; Elisabeth Wilde; Huntington Willard; Howard M Fillit
Journal:  Nat Rev Neurol       Date:  2015-03-17       Impact factor: 42.937

5.  The Alzheimer's Prevention Clinic at Weill Cornell Medical College / New York - Presbyterian Hospital: Risk Stratification and Personalized Early Intervention.

Authors:  A Seifan; R Isaacson
Journal:  J Prev Alzheimers Dis       Date:  2015-10-01

6.  Clinical implications of APOE genotyping for late-onset Alzheimer's disease (LOAD) risk estimation: a review of the literature.

Authors:  Victoria S Marshe; Ilona Gorbovskaya; Sarah Kanji; Maxine Kish; Daniel J Müller
Journal:  J Neural Transm (Vienna)       Date:  2018-10-31       Impact factor: 3.575

7.  From Fraternities to DNA: The Challenge Genetic Prediction Poses to Insurance Markets.

Authors:  Dalton Conley
Journal:  Milbank Q       Date:  2019-01-04       Impact factor: 4.911

Review 8.  Emerging issues in public health genomics.

Authors:  Dana Dolinoy; Beth Tarini; J Scott Roberts
Journal:  Annu Rev Genomics Hum Genet       Date:  2014       Impact factor: 8.929

9.  Should life insurers have access to genetic test results?

Authors:  Robert Klitzman; Paul S Appelbaum; Wendy K Chung
Journal:  JAMA       Date:  2014-11-12       Impact factor: 56.272

10.  How could disclosing incidental information from whole-genome sequencing affect patient behavior?

Authors:  Kurt D Christensen; Robert C Green
Journal:  Per Med       Date:  2013-06       Impact factor: 2.512

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