Literature DB >> 20046991

Aziridines as intermediates in diversity-oriented syntheses of alkaloids.

Alexander M Taylor1, Stuart L Schreiber.   

Abstract

The efficient synthesis of small molecules that collectively comprise optimal small-molecule screening collections is an important goal. With this in mind, we have used N-alkyl aziridines in a regio- and stereochemically controlled synthesis of polycyclic heterocycles based on nucleophilic ring opening and subsequent intramolecular cyclization.

Entities:  

Year:  2009        PMID： 20046991      PMCID： PMC2712733          DOI： 10.1016/j.tetlet.2009.02.034

Source DB:  PubMed          Journal:  Tetrahedron Lett        ISSN： 0040-4039            Impact factor:   2.415


  10 in total

Review 1.  Target-oriented and diversity-oriented organic synthesis in drug discovery.

Authors:  S L Schreiber
Journal:  Science       Date:  2000-03-17       Impact factor: 47.728

2.  Enantioselective ring opening of meso aziridines catalyzed by Tridentate Schiff base chromium(III) complexes.

Authors:  Z Li; M Fernández; E N Jacobsen
Journal:  Org Lett       Date:  1999-11-18       Impact factor: 6.005

3.  A planning strategy for diversity-oriented synthesis.

Authors:  Martin D Burke; Stuart L Schreiber
Journal:  Angew Chem Int Ed Engl       Date:  2004-01       Impact factor: 15.336

Review 4.  Drugs for bad bugs: confronting the challenges of antibacterial discovery.

Authors:  David J Payne; Michael N Gwynn; David J Holmes; David L Pompliano
Journal:  Nat Rev Drug Discov       Date:  2006-12-08       Impact factor: 84.694

5.  The use of vinyl sulfonium salts in the stereocontrolled asymmetric synthesis of epoxide- and aziridine-fused heterocycles: application to the synthesis of (-)-balanol.

Authors:  Matthew G Unthank; Nigel Hussain; Varinder K Aggarwal
Journal:  Angew Chem Int Ed Engl       Date:  2006-10-27       Impact factor: 15.336

6.  Organic chemistry: Molecular diversity by design.

Authors:  Stuart L Schreiber
Journal:  Nature       Date:  2009-01-08       Impact factor: 49.962

7.  Highly selective room-temperature copper-catalyzed C-N coupling reactions.

Authors:  Alexandr Shafir; Stephen L Buchwald
Journal:  J Am Chem Soc       Date:  2006-07-12       Impact factor: 15.419

8.  Facile regio- and stereoselective carbon-carbon coupling of phenol derivatives with aryl aziridines.

Authors:  Mauro Pineschi; Ferruccio Bertolini; Paolo Crotti; Franco Macchia
Journal:  Org Lett       Date:  2006-06-08       Impact factor: 6.005

9.  The Brønsted acid-catalyzed direct aza-Darzens synthesis of N-alkyl cis-aziridines.

Authors:  Amie L Williams; Jeffrey N Johnston
Journal:  J Am Chem Soc       Date:  2004-02-18       Impact factor: 15.419

Review 10.  Towards the optimal screening collection: a synthesis strategy.

Authors:  Thomas E Nielsen; Stuart L Schreiber
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336
  10 in total
  9 in total

1.  Diversity-oriented synthesis as a tool for the discovery of novel biologically active small molecules.

Authors:  Warren R J D Galloway; Albert Isidro-Llobet; David R Spring
Journal:  Nat Commun       Date:  2010-09-21       Impact factor: 14.919

2.  Diversity-oriented synthesis of macrocyclic peptidomimetics.

Authors:  Albert Isidro-Llobet; Tiffanie Murillo; Paula Bello; Agostino Cilibrizzi; James T Hodgkinson; Warren R J D Galloway; Andreas Bender; Martin Welch; David R Spring
Journal:  Proc Natl Acad Sci U S A       Date:  2011-03-07       Impact factor: 11.205

3.  Re-engineering natural products to engage new biological targets.

Authors:  Stephen E Motika; Paul J Hergenrother
Journal:  Nat Prod Rep       Date:  2020-11-18       Impact factor: 13.423

Review 4.  Non-Aziridination Approaches to 3-Arylaziridine-2-carboxylic Acid Derivatives and 3-Aryl-(aziridin-2-yl)ketones.

Authors:  Boriss Strumfs; Kirils Velikijs; Romans Uljanovs; Stanislavs Sinkarevs; Ilze Strumfa
Journal:  Int J Mol Sci       Date:  2022-05-25       Impact factor: 6.208

5.  Indole synthesis: a review and proposed classification.

Authors:  Douglass F Taber; Pavan K Tirunahari
Journal:  Tetrahedron       Date:  2011-09-23       Impact factor: 2.457

6.  A new alkaloid isolated from Abies webbiana leaf.

Authors:  Ashoke K Ghosh; Debanjan Sen; Sanjib Bhattacharya
Journal:  Pharmacognosy Res       Date:  2010-05

7.  Synthesis and ring openings of cinnamate-derived N-unfunctionalised aziridines.

Authors:  Alan Armstrong; Alexandra Ferguson
Journal:  Beilstein J Org Chem       Date:  2012-10-12       Impact factor: 2.883

Review 8.  Preparation and Uses of Chlorinated Glycerol Derivatives.

Authors:  Anna Canela-Xandri; Mercè Balcells; Gemma Villorbina; Paul Christou; Ramon Canela-Garayoa
Journal:  Molecules       Date:  2020-05-28       Impact factor: 4.411

9.  Dihydropyrazole Derivatives Containing Benzo Oxygen Heterocycle and Sulfonamide Moieties Selectively and Potently Inhibit COX-2: Design, Synthesis, and Anti-Colon Cancer Activity Evaluation.

Authors:  Xiao-Qiang Yan; Zhong-Chang Wang; Bo Zhang; Peng-Fei Qi; Gui-Gen Li; Hai-Liang Zhu
Journal:  Molecules       Date:  2019-04-30       Impact factor: 4.411
  9 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.