| Literature DB >> 20044575 |
Elizabeth P Murchison1, Cesar Tovar, Arthur Hsu, Hannah S Bender, Pouya Kheradpour, Clare A Rebbeck, David Obendorf, Carly Conlan, Melanie Bahlo, Catherine A Blizzard, Stephen Pyecroft, Alexandre Kreiss, Manolis Kellis, Alexander Stark, Timothy T Harkins, Jennifer A Marshall Graves, Gregory M Woods, Gregory J Hannon, Anthony T Papenfuss.
Abstract
The Tasmanian devil, a marsupial carnivore, is endangered because of the emergence of a transmissible cancer known as devil facial tumor disease (DFTD). This fatal cancer is clonally derived and is an allograft transmitted between devils by biting. We performed a large-scale genetic analysis of DFTD with microsatellite genotyping, a mitochondrial genome analysis, and deep sequencing of the DFTD transcriptome and microRNAs. These studies confirm that DFTD is a monophyletic clonally transmissible tumor and suggest that the disease is of Schwann cell origin. On the basis of these results, we have generated a diagnostic marker for DFTD and identify a suite of genes relevant to DFTD pathology and transmission. We provide a genomic data set for the Tasmanian devil that is applicable to cancer diagnosis, disease evolution, and conservation biology.Entities:
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Year: 2010 PMID： 20044575 PMCID： PMC2982769 DOI： 10.1126/science.1180616
Source DB: PubMed Journal: Science ISSN： 0036-8075 Impact factor: 47.728