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Literature DB >> 20041844

The role of Notch signaling pathway in epithelial-mesenchymal transition (EMT) during development and tumor aggressiveness.

Zhiwei Wang¹, Yiwei Li, Dejuan Kong, Fazlul H Sarkar.

Abstract

The Notch signaling pathway maintains a balance between cell proliferation and apoptosis, and thus it is believed that Notch signaling pathways may play an important role in the development and progression of several malignancies. However, the functions of Notch signaling in EMT are largely unknown. This mini review describes the role of Notch signaling pathway in EMT, and cataloging how its deregulation is involved in EMT and tumor aggressiveness. Further attempts have been made to summarize the role of several chemopreventive agents that could be useful for targeted inactivation of Notch signaling, and thus it may cause reversal of EMT, which could become a novel approach for cancer prevention and treatment.

Entities: CellLine Chemical Disease Gene Species

Mesh：

Substances：
Receptors, Notch

Year: 2010 PMID： 20041844 PMCID： PMC3084452 DOI： 10.2174/138945010791170860

Source DB: PubMed Journal: Curr Drug Targets ISSN： 1389-4501 Impact factor: 3.465

80 in total

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Journal: Biochim Biophys Acta Date: 2007-10-11

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4. Direct regulation of TWIST by HIF-1alpha promotes metastasis.

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Journal: Nat Cell Biol Date: 2008-02-24 Impact factor: 28.824

5. Notch signaling mediates hypoxia-induced tumor cell migration and invasion.

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Journal: Proc Natl Acad Sci U S A Date: 2008-04-21 Impact factor: 11.205

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Authors: Marcus E Peter
Journal: Cell Cycle Date: 2009-03-22 Impact factor: 4.534

7. Development and characterization of gemcitabine-resistant pancreatic tumor cells.

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8. Modulation of several waves of gene expression during FGF-1 induced epithelial-mesenchymal transition of carcinoma cells.

Authors: Clotilde Billottet; Marianne Tuefferd; David Gentien; Audrey Rapinat; Jean-Paul Thiery; Philippe Broët; Jacqueline Jouanneau
Journal: J Cell Biochem Date: 2008-06-01 Impact factor: 4.429

9. Down-regulation of platelet-derived growth factor-D inhibits cell growth and angiogenesis through inactivation of Notch-1 and nuclear factor-kappaB signaling.

Authors: Zhiwei Wang; Dejuan Kong; Sanjeev Banerjee; Yiwei Li; N Volkan Adsay; James Abbruzzese; Fazlul H Sarkar
Journal: Cancer Res Date: 2007-12-01 Impact factor: 12.701

10. Jagged1-mediated Notch activation induces epithelial-to-mesenchymal transition through Slug-induced repression of E-cadherin.

Authors: Kevin G Leong; Kyle Niessen; Iva Kulic; Afshin Raouf; Connie Eaves; Ingrid Pollet; Aly Karsan
Journal: J Exp Med Date: 2007-11-05 Impact factor: 14.307

121 in total

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Review 2. Targeting CSCs in tumor microenvironment: the potential role of ROS-associated miRNAs in tumor aggressiveness.

Authors: Bin Bao; Asfar S Azmi; Yiwei Li; Aamir Ahmad; Shadan Ali; Sanjeev Banerjee; Dejuan Kong; Fazlul H Sarkar
Journal: Curr Stem Cell Res Ther Date: 2014-01 Impact factor: 3.828

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Authors: Jing-Jing Zhang; San-Jun Chu; Xiao-Lei Sun; Ting Zhang; Wei-Yun Shi
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4. A method to measure cellular adhesion utilizing a polymer micro-cantilever.

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Review 5. p21-Activated Kinases in Thyroid Cancer.

Authors: Luis Bautista; Christina M Knippler; Matthew D Ringel
Journal: Endocrinology Date: 2020-08-01 Impact factor: 4.736

6. CLDN-1 promoted the epithelial to migration and mesenchymal transition (EMT) in human bronchial epithelial cells via Notch pathway.

Authors: Jing Lv; Baohua Sun; Zhitao Mai; Mingming Jiang; Junfeng Du
Journal: Mol Cell Biochem Date: 2017-03-18 Impact factor: 3.396