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Literature DB >> 32609833

p21-Activated Kinases in Thyroid Cancer.

Luis Bautista¹, Christina M Knippler^1,2, Matthew D Ringel¹.

Abstract

The family of p21-activated kinases (PAKs) are oncogenic proteins that regulate critical cellular functions. PAKs play central signaling roles in the integrin/CDC42/Rho, ERK/MAPK, PI3K/AKT, NF-κB, and Wnt/β-catenin pathways, functioning both as kinases and scaffolds to regulate cell motility, mitosis and proliferation, cytoskeletal rearrangement, and other cellular activities. PAKs have been implicated in both the development and progression of a wide range of cancers, including breast cancer, pancreatic melanoma, thyroid cancer, and others. Here we will discuss the current knowledge on the structure and biological functions of both group I and group II PAKs, as well as the roles that PAKs play in oncogenesis and progression, with a focus on thyroid cancer and emerging data regarding BRAF/PAK signaling. © Endocrine Society 2020. All rights reserved. For permissions, please e-mail: journals.permissions@oup.com.

Entities: Disease Gene

Keywords: BRAF; PAK; cancer; p21-activated kinase; thyroid cancer

Mesh：

Substances：

Year: 2020 PMID： 32609833 PMCID： PMC7417880 DOI： 10.1210/endocr/bqaa105

Source DB: PubMed Journal: Endocrinology ISSN： 0013-7227 Impact factor: 4.736

140 in total

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Journal: Cancer Res Date: 2003-05-01 Impact factor: 12.701

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Authors: Zhou-shen Zhao; Ed Manser
Journal: Biochem J Date: 2005-03-01 Impact factor: 3.857

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Authors: Jue Wang; Jia-Wei Wu; Zhi-Xin Wang
Journal: Structure Date: 2011-12-07 Impact factor: 5.006

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Authors: Z S Zhao; E Manser; X Q Chen; C Chong; T Leung; L Lim
Journal: Mol Cell Biol Date: 1998-04 Impact factor: 4.272

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Authors: C Xia; W Ma; L J Stafford; S Marcus; W C Xiong; M Liu
Journal: Proc Natl Acad Sci U S A Date: 2001-05-22 Impact factor: 11.205

6. Gene expression and functional evidence of epithelial-to-mesenchymal transition in papillary thyroid carcinoma invasion.

Authors: Vasily Vasko; Allan V Espinosa; William Scouten; Huiling He; Herbert Auer; Sandya Liyanarachchi; Alexander Larin; Victoria Savchenko; Gary L Francis; Albert de la Chapelle; Motoyasu Saji; Matthew D Ringel
Journal: Proc Natl Acad Sci U S A Date: 2007-02-12 Impact factor: 11.205

7. Pak4, a novel Gab1 binding partner, modulates cell migration and invasion by the Met receptor.

Authors: Grigorios N Paliouras; Monica A Naujokas; Morag Park
Journal: Mol Cell Biol Date: 2009-03-16 Impact factor: 4.272

8. PAK1-dependent MAPK pathway activation is required for colorectal cancer cell proliferation.

Authors: Haitao Qing; Wei Gong; Yufang Che; Xinying Wang; Liang Peng; Yan Liang; Weifei Wang; Qiliang Deng; Hongquan Zhang; Bo Jiang
Journal: Tumour Biol Date: 2012-01-18

9. Solution structures and biophysical analysis of full-length group A PAKs reveal they are monomeric and auto-inhibited in cis.

Authors: Fiona J Sorrell; Lena Marie Kilian; Jonathan M Elkins
Journal: Biochem J Date: 2019-04-04 Impact factor: 3.857

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Authors: E A Clark; W G King; J S Brugge; M Symons; R O Hynes
Journal: J Cell Biol Date: 1998-07-27 Impact factor: 10.539

4 in total

1. Expression of phosphorylated p21-activated kinase 4 is associated with aggressive histologic characteristics and poor prognosis in patients with surgically treated renal cell carcinoma.

Authors: Ho Won Kang; Xuan Mei Piao; Hee Youn Lee; Kyeong Kim; Sung Pil Seo; Yun Sok Ha; Yeong Uk Kim; Won Tae Kim; Yong June Kim; Sang Cheol Lee; Wun Jae Kim; Eun Young Shin; Eung Gook Kim; Seok Joong Yun
Journal: Investig Clin Urol Date: 2021-05-17