| Literature DB >> 20041291 |
Sung-Hwa Sohn1, Sun Kwang Kim, Eunjung Ko, Youngseop Lee, Hwan-Suck Chung, Hyojung Lee, Hyunseong Kim, Deok-Sang Hwang, Sangsoo Nam, Hyunsu Bae.
Abstract
Previously, we demonstrated that electoracupuncture (EA) suppressed allergic reactions in DNP-KLH immunized mice. In this study, the mechanisms by which EA induces immunomodulation in the immunized mice were evaluated by genome-wide microarray analysis. The anti-allergic effects of EA in DNP-KLH immunized mice were confirmed by analyzing antigen specific IgE using ELISA. Microarray analysis, followed by real time RT-PCR validation, revealed that Th1 and Th17 cytokine-, opioid peptide-, and anti-apoptosis-related genes were up-regulated upon treatment with EA. In addition, significant decreases in Th2 cytokine-, MAPK signaling pathway-, and apoptosis-related genes were observed following EA treatment.Entities:
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Year: 2009 PMID： 20041291 DOI： 10.1007/s10571-009-9487-y
Source DB: PubMed Journal: Cell Mol Neurobiol ISSN： 0272-4340 Impact factor: 5.046