Literature DB >> 17669590

The alpha-adrenoceptor mediation of the immunomodulatory effects of electroacupuncture in DNP-KLH immunized mice.

Youngseop Lee1, Sun Kwang Kim, Yangseok Kim, Hyejung Lee, Min-Kyu Shin, Moo-Chang Hong, Byung-Il Min, Hyunsu Bae.   

Abstract

Our previous study demonstrated that successive electroacupuncture (EA) at ST36 acupoint reduces IgE production in BALB/c mice immunized with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH) by suppression of the Th2 cell lineage development. Here, we report that pretreatment of phentolamine (alpha-adrenoceptor antagonist, 10mg/kg, i.p.) completely blocks the EA-induced suppression of antigen-specific and total IgE levels in serum and IL-4 production in anti-CD3 mAb-activated splenocytes in DNP-KLH immunized mice. The results suggest that alpha-adrenoceptor play an important role in mediating the suppressive effects of EA on IgE production and Th2 cell response in DNP-KLH immunized mice.

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Year:  2007        PMID： 17669590     DOI： 10.1016/j.neulet.2007.07.002

Source DB:  PubMed          Journal:  Neurosci Lett        ISSN： 0304-3940            Impact factor:   3.046


  6 in total

1.  The genome-wide expression profile of electroacupuncture in DNP-KLH immunized mice.

Authors:  Sung-Hwa Sohn; Sun Kwang Kim; Eunjung Ko; Youngseop Lee; Hwan-Suck Chung; Hyojung Lee; Hyunseong Kim; Deok-Sang Hwang; Sangsoo Nam; Hyunsu Bae
Journal:  Cell Mol Neurobiol       Date:  2009-12-30       Impact factor: 5.046

2.  Gene Expression Profile of the Hypothalamus in DNP-KLH Immunized Mice Following Electroacupuncture Stimulation.

Authors:  Sun Kwang Kim; Jeungshin Kim; Eunjung Ko; Hyunseong Kim; Deok-Sang Hwang; Sanghoon Lee; Yonghyeon Baek; Byung-Il Min; Sangsoo Nam; Hyunsu Bae
Journal:  Evid Based Complement Alternat Med       Date:  2011-06-05       Impact factor: 2.629

3.  Electroacupuncture Attenuates Ovalbumin-Induced Allergic Asthma via Modulating CD4(+)CD25(+) Regulatory T Cells.

Authors:  Youngjoo Kwon; Sung-Hwa Sohn; Gihyun Lee; Youngeun Kim; Hyejung Lee; Minkyu Shin; Hyunsu Bae
Journal:  Evid Based Complement Alternat Med       Date:  2012-05-10       Impact factor: 2.629

4.  Effects of preventive acupuncture and moxibustion on fat accumulation, blood lipid, and uterus e 2 of menopause rats.

Authors:  Shi-Peng Zhu; Yu-Wei He; Huan Chen; Zhi-Fang Sun; Na Ding; Jie Mo; Bing-Yan Cao; Li Luo; Qing-Qing Zhang; Yang Wang; Lu-Fen Zhang; Xiao-Xuan Ren; Meng-Wei Guo; Ya-Fang Zhao; Liang-Xiao Ma; Xiao-Hong Li
Journal:  Evid Based Complement Alternat Med       Date:  2014-02-04       Impact factor: 2.629

5.  Biomedicine and traditional Chinese medicine: a fruitful scientific and cultural interaction.

Authors:  Lorenzo Mortara; Grace Coco; Cristina Pozzi
Journal:  Acta Biomed       Date:  2022-03-14

6.  A Parametric Study on the Immunomodulatory Effects of Electroacupuncture in DNP-KLH Immunized Mice.

Authors:  Sun Kwang Kim; Youngseop Lee; Hyunjoo Cho; Sungtae Koo; Sun Mi Choi; Min-Kyu Shin; Moo-Chang Hong; Byung-Il Min; Hyunsu Bae
Journal:  Evid Based Complement Alternat Med       Date:  2011-02-14       Impact factor: 2.629
  6 in total

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