| Literature DB >> 15145602 |
Moon-Baik Park1, Eunjung Ko, Changjoon Ahn, Hyun Choi, Samwoong Rho, Min-Kyu Shin, Moo-Chang Hong, Byung-Il Min, Hyunsu Bae.
Abstract
Effects of electroacupuncture (EA) on Th1/Th2 cell response were investigated in BALB/c mice immunized intraperitoneally with 2,4-dinitrophenylated keyhole limpet protein (DNP-KLH). Successive electroacupuncture stimulation on the ST36 acupoint was performed just after immunization. Serum levels of antigen-specific IgE and total IgE were significantly decreased compared with non-acupunctured controls. Production of the Th2-specific cytokines IL-4 and IL-13 in the anti-CD3 mAb-activated splenocytes was significantly suppressed in ST36 electroacupunctured mice compared with non-acupunctured mice. These results imply that successive electroacupuncture on ST36 can decrease the serum level of antigen-specific IgE and total IgE by suppression of the Th2 lineage development.Entities:
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Year: 2004 PMID： 15145602 DOI： 10.1016/j.jneuroim.2004.02.003
Source DB: PubMed Journal: J Neuroimmunol ISSN： 0165-5728 Impact factor: 3.478