BACKGROUND: The risk of myocardial infarction is lower among light-to-moderate alcohol drinkers compared with abstainers. We tested associations between alcohol intake and risk of myocardial infarction and risk factors and whether these associations are modified by variations in alcohol dehydrogenases. METHODS AND RESULTS: We used information on 9584 men and women from the Danish general population in the Copenhagen City Heart Study. During follow-up, from 1991 to 2007, 663 incident cases of myocardial infarction occurred. We observed that increasing alcohol intake was associated with decreasing risk of myocardial infarction, decreasing low-density lipoprotein cholesterol and fibrinogen, increasing diastolic and systolic blood pressure and high-density lipoprotein cholesterol, and with U-shaped nonfasting triglycerides. In contrast, ADH1B and ADH1C genotypes were not associated with risk of myocardial infarction or with any of the cardiovascular biochemical risk factors, and there was no indication that associations between alcohol intake and myocardial infarction and between alcohol intake and risk factors were modified by genotypes. CONCLUSIONS: Increasing alcohol intake is associated with decreasing risk of myocardial infarction, decreasing low-density lipoprotein cholesterol and fibrinogen, increasing diastolic and systolic blood pressure and high-density lipoprotein cholesterol, and U-shaped nonfasting triglycerides. These associations were not modified by ADH1B and ADH1C are genotypes.
BACKGROUND: The risk of myocardial infarction is lower among light-to-moderate alcohol drinkers compared with abstainers. We tested associations between alcohol intake and risk of myocardial infarction and risk factors and whether these associations are modified by variations in alcohol dehydrogenases. METHODS AND RESULTS: We used information on 9584 men and women from the Danish general population in the Copenhagen City Heart Study. During follow-up, from 1991 to 2007, 663 incident cases of myocardial infarction occurred. We observed that increasing alcohol intake was associated with decreasing risk of myocardial infarction, decreasing low-density lipoprotein cholesterol and fibrinogen, increasing diastolic and systolic blood pressure and high-density lipoprotein cholesterol, and with U-shaped nonfasting triglycerides. In contrast, ADH1B and ADH1C genotypes were not associated with risk of myocardial infarction or with any of the cardiovascular biochemical risk factors, and there was no indication that associations between alcohol intake and myocardial infarction and between alcohol intake and risk factors were modified by genotypes. CONCLUSIONS: Increasing alcohol intake is associated with decreasing risk of myocardial infarction, decreasing low-density lipoprotein cholesterol and fibrinogen, increasing diastolic and systolic blood pressure and high-density lipoprotein cholesterol, and U-shaped nonfasting triglycerides. These associations were not modified by ADH1B and ADH1C are genotypes.
Authors: C Charneira; N M Grilo; S A Pereira; A L A Godinho; E C Monteiro; M M Marques; A M M Antunes Journal: Br J Pharmacol Date: 2012-11 Impact factor: 8.739
Authors: John B Whitfield; Andrew C Heath; Pamela A F Madden; Michele L Pergadia; Grant W Montgomery; Nicholas G Martin Journal: Alcohol Clin Exp Res Date: 2012-11-07 Impact factor: 3.455
Authors: Ana Torres do Rego; Boudewijn Klop; Erwin Birnie; Jan Willem F Elte; Victoria Cachofeiro Ramos; Luis A Alvarez-Sala Walther; Manuel Castro Cabezas Journal: Nutrients Date: 2013-12-16 Impact factor: 5.717
Authors: Peter Würtz; Sarah Cook; Qin Wang; Mika Tiainen; Tuulia Tynkkynen; Antti J Kangas; Pasi Soininen; Jaana Laitinen; Jorma Viikari; Mika Kähönen; Terho Lehtimäki; Markus Perola; Stefan Blankenberg; Tanja Zeller; Satu Männistö; Veikko Salomaa; Marjo-Riitta Järvelin; Olli T Raitakari; Mika Ala-Korpela; David A Leon Journal: Int J Epidemiol Date: 2016-08-05 Impact factor: 7.196
Authors: Michael V Holmes; Caroline E Dale; Luisa Zuccolo; Richard J Silverwood; Yiran Guo; Zheng Ye; David Prieto-Merino; Abbas Dehghan; Stella Trompet; Andrew Wong; Alana Cavadino; Dagmar Drogan; Sandosh Padmanabhan; Shanshan Li; Ajay Yesupriya; Maarten Leusink; Johan Sundstrom; Jaroslav A Hubacek; Hynek Pikhart; Daniel I Swerdlow; Andrie G Panayiotou; Svetlana A Borinskaya; Chris Finan; Sonia Shah; Karoline B Kuchenbaecker; Tina Shah; Jorgen Engmann; Lasse Folkersen; Per Eriksson; Fulvio Ricceri; Olle Melander; Carlotta Sacerdote; Dale M Gamble; Sruti Rayaprolu; Owen A Ross; Stela McLachlan; Olga Vikhireva; Ivonne Sluijs; Robert A Scott; Vera Adamkova; Leon Flicker; Frank M van Bockxmeer; Christine Power; Pedro Marques-Vidal; Tom Meade; Michael G Marmot; Jose M Ferro; Sofia Paulos-Pinheiro; Steve E Humphries; Philippa J Talmud; Irene Mateo Leach; Niek Verweij; Allan Linneberg; Tea Skaaby; Pieter A Doevendans; Maarten J Cramer; Pim van der Harst; Olaf H Klungel; Nicole F Dowling; Anna F Dominiczak; Meena Kumari; Andrew N Nicolaides; Cornelia Weikert; Heiner Boeing; Shah Ebrahim; Tom R Gaunt; Jackie F Price; Lars Lannfelt; Anne Peasey; Ruzena Kubinova; Andrzej Pajak; Sofia Malyutina; Mikhail I Voevoda; Abdonas Tamosiunas; Anke H Maitland-van der Zee; Paul E Norman; Graeme J Hankey; Manuela M Bergmann; Albert Hofman; Oscar H Franco; Jackie Cooper; Jutta Palmen; Wilko Spiering; Pim A de Jong; Diana Kuh; Rebecca Hardy; Andre G Uitterlinden; M Arfan Ikram; Ian Ford; Elina Hyppönen; Osvaldo P Almeida; Nicholas J Wareham; Kay-Tee Khaw; Anders Hamsten; Lise Lotte N Husemoen; Anne Tjønneland; Janne S Tolstrup; Eric Rimm; Joline W J Beulens; W M Monique Verschuren; N Charlotte Onland-Moret; Marten H Hofker; S Goya Wannamethee; Peter H Whincup; Richard Morris; Astrid M Vicente; Hugh Watkins; Martin Farrall; J Wouter Jukema; James Meschia; L Adrienne Cupples; Stephen J Sharp; Myriam Fornage; Charles Kooperberg; Andrea Z LaCroix; James Y Dai; Matthew B Lanktree; David S Siscovick; Eric Jorgenson; Bonnie Spring; Josef Coresh; Yun R Li; Sarah G Buxbaum; Pamela J Schreiner; R Curtis Ellison; Michael Y Tsai; Sanjay R Patel; Susan Redline; Andrew D Johnson; Ron C Hoogeveen; Hakon Hakonarson; Jerome I Rotter; Eric Boerwinkle; Paul I W de Bakker; Mika Kivimaki; Folkert W Asselbergs; Naveed Sattar; Debbie A Lawlor; John Whittaker; George Davey Smith; Kenneth Mukamal; Bruce M Psaty; James G Wilson; Leslie A Lange; Ajna Hamidovic; Aroon D Hingorani; Børge G Nordestgaard; Martin Bobak; David A Leon; Claudia Langenberg; Tom M Palmer; Alex P Reiner; Brendan J Keating; Frank Dudbridge; Juan P Casas Journal: BMJ Date: 2014-07-10