BACKGROUND: Alcohol consumption has multiple biochemical consequences. Only a few of these are useful as diagnostic markers, but many reflect potentially harmful or beneficial effects of alcohol. Average consumption of 2 to 4 drinks per day is associated with lower overall or cardiovascular mortality risk than either lower or higher intake. We have analyzed the dose-response relationships between reported alcohol consumption and 17 biomarkers, with emphasis on intake of up to 3 drinks per day. METHODS: Biochemical tests were performed on serum from 8,396 study participants (3,750 men and 4,646 women, aged 51 ± 13 years, range 18 to 93) who had provided information on alcohol consumption in the week preceding blood collection. RESULTS: Gamma glutamyl transferase, alanine aminotransferase, aspartate aminotransferase, carbohydrate-deficient transferrin, urate, ferritin, and bilirubin showed little or no change with alcohol consumption below 2 to 3 drinks per day, but increased with higher intake. High-density lipoprotein cholesterol and albumin showed increasing results, and insulin showed decreasing results, across the entire range of alcohol use. Biphasic responses, where subjects reporting 1 to 2 drinks per day had lower results than those reporting either more or less alcohol use, occurred for triglycerides, glucose, C-reactive protein, alkaline phosphatase, and butyrylcholinesterase. Increasing alcohol use was associated with decreasing low-density lipoprotein cholesterol (LDL-C) in younger women, but higher LDL-C in older men. CONCLUSIONS: Some markers show threshold relationships with alcohol, others show continuous ones, and a third group show biphasic or U-shaped relationships. Overall, the biochemical sequelae of low-to-moderate alcohol use are consistent with the epidemiological evidence on morbidity and mortality.
BACKGROUND:Alcohol consumption has multiple biochemical consequences. Only a few of these are useful as diagnostic markers, but many reflect potentially harmful or beneficial effects of alcohol. Average consumption of 2 to 4 drinks per day is associated with lower overall or cardiovascular mortality risk than either lower or higher intake. We have analyzed the dose-response relationships between reported alcohol consumption and 17 biomarkers, with emphasis on intake of up to 3 drinks per day. METHODS: Biochemical tests were performed on serum from 8,396 study participants (3,750 men and 4,646 women, aged 51 ± 13 years, range 18 to 93) who had provided information on alcohol consumption in the week preceding blood collection. RESULTS: Gamma glutamyl transferase, alanine aminotransferase, aspartate aminotransferase, carbohydrate-deficient transferrin, urate, ferritin, and bilirubin showed little or no change with alcohol consumption below 2 to 3 drinks per day, but increased with higher intake. High-density lipoprotein cholesterol and albumin showed increasing results, and insulin showed decreasing results, across the entire range of alcohol use. Biphasic responses, where subjects reporting 1 to 2 drinks per day had lower results than those reporting either more or less alcohol use, occurred for triglycerides, glucose, C-reactive protein, alkaline phosphatase, and butyrylcholinesterase. Increasing alcohol use was associated with decreasing low-density lipoprotein cholesterol (LDL-C) in younger women, but higher LDL-C in older men. CONCLUSIONS: Some markers show threshold relationships with alcohol, others show continuous ones, and a third group show biphasic or U-shaped relationships. Overall, the biochemical sequelae of low-to-moderate alcohol use are consistent with the epidemiological evidence on morbidity and mortality.
Authors: Andrew C Heath; John B Whitfield; Nicholas G Martin; Michele L Pergadia; Alison M Goate; Penelope A Lind; Brian P McEvoy; Andrew J Schrage; Julia D Grant; Yi-Ling Chou; Rachel Zhu; Anjali K Henders; Sarah E Medland; Scott D Gordon; Elliot C Nelson; Arpana Agrawal; Dale R Nyholt; Kathleen K Bucholz; Pamela A F Madden; Grant W Montgomery Journal: Biol Psychiatry Date: 2011-05-06 Impact factor: 13.382
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Authors: Bryan R Spencer; Yuelong Guo; Ritchard G Cable; Joseph E Kiss; Michael P Busch; Grier P Page; Stacy M Endres-Dighe; Steven Kleinman; Simone A Glynn; Alan E Mast Journal: Transfusion Date: 2019-07-18 Impact factor: 3.157
Authors: Satish A Eraly; Caroline M Nievergelt; Adam X Maihofer; Donald A Barkauskas; Nilima Biswas; Agorastos Agorastos; Daniel T O'Connor; Dewleen G Baker Journal: JAMA Psychiatry Date: 2014-04 Impact factor: 21.596
Authors: Elizabeth Mostofsky; Harpreet S Chahal; Kenneth J Mukamal; Eric B Rimm; Murray A Mittleman Journal: Circulation Date: 2016-03-08 Impact factor: 29.690
Authors: Zhe Wang; Han Chen; Traci M Bartz; Lawrence F Bielak; Daniel I Chasman; Mary F Feitosa; Nora Franceschini; Xiuqing Guo; Elise Lim; Raymond Noordam; Melissa A Richard; Heming Wang; Brian Cade; L Adrienne Cupples; Paul S de Vries; Franco Giulanini; Jiwon Lee; Rozenn N Lemaitre; Lisa W Martin; Alex P Reiner; Stephen S Rich; Pamela J Schreiner; Stephen Sidney; Colleen M Sitlani; Jennifer A Smith; Ko Willems van Dijk; Jie Yao; Wei Zhao; Myriam Fornage; Sharon L R Kardia; Charles Kooperberg; Ching-Ti Liu; Dennis O Mook-Kanamori; Michael A Province; Bruce M Psaty; Susan Redline; Paul M Ridker; Jerome I Rotter; Eric Boerwinkle; Alanna C Morrison Journal: Circ Genom Precis Med Date: 2020-06-08
Authors: Paul S de Vries; Michael R Brown; Amy R Bentley; Yun J Sung; Thomas W Winkler; Ioanna Ntalla; Karen Schwander; Aldi T Kraja; Xiuqing Guo; Nora Franceschini; Ching-Yu Cheng; Xueling Sim; Dina Vojinovic; Jennifer E Huffman; Solomon K Musani; Changwei Li; Mary F Feitosa; Melissa A Richard; Raymond Noordam; Hugues Aschard; Traci M Bartz; Lawrence F Bielak; Xuan Deng; Rajkumar Dorajoo; Kurt K Lohman; Alisa K Manning; Tuomo Rankinen; Albert V Smith; Salman M Tajuddin; Evangelos Evangelou; Mariaelisa Graff; Maris Alver; Mathilde Boissel; Jin Fang Chai; Xu Chen; Jasmin Divers; Ilaria Gandin; Chuan Gao; Anuj Goel; Yanick Hagemeijer; Sarah E Harris; Fernando P Hartwig; Meian He; Andrea R V R Horimoto; Fang-Chi Hsu; Anne U Jackson; Anuradhani Kasturiratne; Pirjo Komulainen; Brigitte Kühnel; Federica Laguzzi; Joseph H Lee; Jian'an Luan; Leo-Pekka Lyytikäinen; Nana Matoba; Ilja M Nolte; Maik Pietzner; Muhammad Riaz; M Abdullah Said; Robert A Scott; Tamar Sofer; Alena Stančáková; Fumihiko Takeuchi; Bamidele O Tayo; Peter J van der Most; Tibor V Varga; Yajuan Wang; Erin B Ware; Wanqing Wen; Lisa R Yanek; Weihua Zhang; Jing Hua Zhao; Saima Afaq; Najaf Amin; Marzyeh Amini; Dan E Arking; Tin Aung; Christie Ballantyne; Eric Boerwinkle; Ulrich Broeckel; Archie Campbell; Mickaël Canouil; Sabanayagam Charumathi; Yii-Der Ida Chen; John M Connell; Ulf de Faire; Lisa de Las Fuentes; Renée de Mutsert; H Janaka de Silva; Jingzhong Ding; Anna F Dominiczak; Qing Duan; Charles B Eaton; Ruben N Eppinga; Jessica D Faul; Virginia Fisher; Terrence Forrester; Oscar H Franco; Yechiel Friedlander; Mohsen Ghanbari; Franco Giulianini; Hans J Grabe; Megan L Grove; C Charles Gu; Tamara B Harris; Sami Heikkinen; Chew-Kiat Heng; Makoto Hirata; James E Hixson; Barbara V Howard; M Arfan Ikram; David R Jacobs; Craig Johnson; Jost Bruno Jonas; Candace M Kammerer; Tomohiro Katsuya; Chiea Chuen Khor; Tuomas O Kilpeläinen; Woon-Puay Koh; Heikki A Koistinen; Ivana Kolcic; Charles Kooperberg; Jose E Krieger; Steve B Kritchevsky; Michiaki Kubo; Johanna Kuusisto; Timo A Lakka; Carl D Langefeld; Claudia Langenberg; Lenore J Launer; Benjamin Lehne; Rozenn N Lemaitre; Yize Li; Jingjing Liang; Jianjun Liu; Kiang Liu; Marie Loh; Tin Louie; Reedik Mägi; Ani W Manichaikul; Colin A McKenzie; Thomas Meitinger; Andres Metspalu; Yuri Milaneschi; Lili Milani; Karen L Mohlke; Thomas H Mosley; Kenneth J Mukamal; Mike A Nalls; Matthias Nauck; Christopher P Nelson; Nona Sotoodehnia; Jeff R O'Connell; Nicholette D Palmer; Raha Pazoki; Nancy L Pedersen; Annette Peters; Patricia A Peyser; Ozren Polasek; Neil Poulter; Leslie J Raffel; Olli T Raitakari; Alex P Reiner; Treva K Rice; Stephen S Rich; Antonietta Robino; Jennifer G Robinson; Lynda M Rose; Igor Rudan; Carsten O Schmidt; Pamela J Schreiner; William R Scott; Peter Sever; Yuan Shi; Stephen Sidney; Mario Sims; Blair H Smith; Jennifer A Smith; Harold Snieder; John M Starr; Konstantin Strauch; Nicholas Tan; Kent D Taylor; Yik Ying Teo; Yih Chung Tham; André G Uitterlinden; Diana van Heemst; Dragana Vuckovic; Melanie Waldenberger; Lihua Wang; Yujie Wang; Zhe Wang; Wen Bin Wei; Christine Williams; Gregory Wilson; Mary K Wojczynski; Jie Yao; Bing Yu; Caizheng Yu; Jian-Min Yuan; Wei Zhao; Alan B Zonderman; Diane M Becker; Michael Boehnke; Donald W Bowden; John C Chambers; Ian J Deary; Tõnu Esko; Martin Farrall; Paul W Franks; Barry I Freedman; Philippe Froguel; Paolo Gasparini; Christian Gieger; Bernardo L Horta; Yoichiro Kamatani; Norihiro Kato; Jaspal S Kooner; Markku Laakso; Karin Leander; Terho Lehtimäki; Patrik K E Magnusson; Brenda Penninx; Alexandre C Pereira; Rainer Rauramaa; Nilesh J Samani; James Scott; Xiao-Ou Shu; Pim van der Harst; Lynne E Wagenknecht; Ya Xing Wang; Nicholas J Wareham; Hugh Watkins; David R Weir; Ananda R Wickremasinghe; Wei Zheng; Paul Elliott; Kari E North; Claude Bouchard; Michele K Evans; Vilmundur Gudnason; Ching-Ti Liu; Yongmei Liu; Bruce M Psaty; Paul M Ridker; Rob M van Dam; Sharon L R Kardia; Xiaofeng Zhu; Charles N Rotimi; Dennis O Mook-Kanamori; Myriam Fornage; Tanika N Kelly; Ervin R Fox; Caroline Hayward; Cornelia M van Duijn; E Shyong Tai; Tien Yin Wong; Jingmin Liu; Jerome I Rotter; W James Gauderman; Michael A Province; Patricia B Munroe; Kenneth Rice; Daniel I Chasman; L Adrienne Cupples; Dabeeru C Rao; Alanna C Morrison Journal: Am J Epidemiol Date: 2019-06-01 Impact factor: 5.363
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