Literature DB >> 20024241

Products of the iterative polyketide synthases in 9- and 10-membered enediyne biosynthesis.

Huihua Sun1, Rong Kong, Di Zhu, Min Lu, Qiang Ji, Chong Wai Liew, Julien Lescar, Guofu Zhong, Zhao-Xun Liang.   

Abstract

The iterative polyketide synthases from the biosynthetic pathways of three enediyne natural products were examined. The results established the all-trans conjugated pentadecaheptanene as the only major product shared by the PKSs. The experiments further revealed some intrinsic differences among the PKSs by demonstrating the formation of different by-products.

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Year:  2009        PMID： 20024241     DOI： 10.1039/b916751j

Source DB:  PubMed          Journal:  Chem Commun (Camb)        ISSN： 1359-7345            Impact factor:   6.222


  9 in total

1.  Polyketide synthase chemistry does not direct biosynthetic divergence between 9- and 10-membered enediynes.

Authors:  Geoff P Horsman; Yihua Chen; Jon S Thorson; Ben Shen
Journal:  Proc Natl Acad Sci U S A       Date:  2010-06-07       Impact factor: 11.205

2.  Rigidifying acyl carrier protein domain in iterative type I PKS CalE8 does not affect its function.

Authors:  Jackwee Lim; Huihua Sun; Jing-Song Fan; Iman Fahim Hameed; Julien Lescar; Zhao-Xun Liang; Daiwen Yang
Journal:  Biophys J       Date:  2012-09-05       Impact factor: 4.033

3.  Environmental control of the calicheamicin polyketide synthase leads to detection of a programmed octaketide and a proposal for enediyne biosynthesis.

Authors:  Katherine Belecki; Craig A Townsend
Journal:  Angew Chem Int Ed Engl       Date:  2012-10-08       Impact factor: 15.336

4.  Synthesis of a 2,4,6,8,10-dodecapentanoic acid thioester as a substrate for biosynthesis of Heat Stable Antifungal Factor (HSAF).

Authors:  Andrew S Olson; Haotong Chen; Liangcheng Du; Patrick H Dussault
Journal:  RSC Adv       Date:  2015       Impact factor: 3.361

5.  Crystal structure of the acyltransferase domain of the iterative polyketide synthase in enediyne biosynthesis.

Authors:  Chong Wai Liew; Martina Nilsson; Ming Wei Chen; Huihua Sun; Tobias Cornvik; Zhao-Xun Liang; Julien Lescar
Journal:  J Biol Chem       Date:  2012-05-15       Impact factor: 5.157

6.  Solution structures of the acyl carrier protein domain from the highly reducing type I iterative polyketide synthase CalE8.

Authors:  Jackwee Lim; Rong Kong; Elavazhagan Murugan; Chun Loong Ho; Zhao-Xun Liang; Daiwen Yang
Journal:  PLoS One       Date:  2011-06-02       Impact factor: 3.240

7.  Regio- and stereoselective monoepoxidation of dienes using methyltrioxorhenium: synthesis of allylic epoxides.

Authors:  Saroj Ranjan De; Ganesh Kumar; Jawahar L Jat; Saritha Birudaraju; Biao Lu; Rajkumar Manne; Narender Puli; Adeniyi Michael Adebesin; John R Falck
Journal:  J Org Chem       Date:  2014-10-27       Impact factor: 4.354

8.  Enediyne polyketide synthases stereoselectively reduce the β-ketoacyl intermediates to β-D-hydroxyacyl intermediates in enediyne core biosynthesis.

Authors:  Hui-Ming Ge; Tingting Huang; Jeffrey D Rudolf; Jeremy R Lohman; Sheng-Xiong Huang; Xun Guo; Ben Shen
Journal:  Org Lett       Date:  2014-07-14       Impact factor: 6.005

9.  Crystal Structure of Thioesterase SgcE10 Supporting Common Polyene Intermediates in 9- and 10-Membered Enediyne Core Biosynthesis.

Authors:  Thibault Annaval; Jeffrey D Rudolf; Chin-Yuan Chang; Jeremy R Lohman; Youngchang Kim; Lance Bigelow; Robert Jedrzejczak; Gyorgy Babnigg; Andrzej Joachimiak; George N Phillips; Ben Shen
Journal:  ACS Omega       Date:  2017-08-30
  9 in total

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