OBJECTIVES: To identify the frequency of caspofungin-non-susceptible Candida isolates in cancer patients with candidiasis. METHODS: We reviewed the in vitro susceptibilities (M27-A3 CLSI method) of 650 Candida spp. associated with invasive candidiasis episodes in 582 hospitalized cancer patients (2005-08). RESULTS AND CONCLUSIONS: We identified seven caspofungin-non-susceptible Candida strains (three Candida tropicalis, two Candida glabrata and two Candida albicans) from 650 Candida isolates (1%). C. tropicalis (three out of seven) was the most common non-susceptible species isolated. All patients responded to a change of antifungal therapy. Further surveillance should focus on the potential broader emergence of echinocandin resistance, as the clinical use of this antifungal class continues to expand in cancer patients.
OBJECTIVES: To identify the frequency of caspofungin-non-susceptible Candida isolates in cancerpatients with candidiasis. METHODS: We reviewed the in vitro susceptibilities (M27-A3 CLSI method) of 650 Candida spp. associated with invasive candidiasis episodes in 582 hospitalized cancerpatients (2005-08). RESULTS AND CONCLUSIONS: We identified seven caspofungin-non-susceptible Candida strains (three Candida tropicalis, two Candida glabrata and two Candida albicans) from 650 Candida isolates (1%). C. tropicalis (three out of seven) was the most common non-susceptible species isolated. All patients responded to a change of antifungal therapy. Further surveillance should focus on the potential broader emergence of echinocandin resistance, as the clinical use of this antifungal class continues to expand in cancerpatients.
Authors: Alexander Lepak; Mariana Castanheira; Daniel Diekema; Michael Pfaller; David Andes Journal: Antimicrob Agents Chemother Date: 2012-09-04 Impact factor: 5.191
Authors: Ying-Lien Chen; Alexandra Brand; Emma L Morrison; Fitz Gerald S Silao; Ursela G Bigol; Fedelino F Malbas; Jeniel E Nett; David R Andes; Norma V Solis; Scott G Filler; Anna Averette; Joseph Heitman Journal: Eukaryot Cell Date: 2011-04-29
Authors: Lourimar Viana Nascimento F de Sousa; Vera Lúcia Santos; Andrea de Souza Monteiro; Marcus Vinicíus Dias-Souza; Sirlei Garcia Marques; Elaine Speziali de Faria; Elaine Alves de Oliveira Assunção; Simone Gonçalves Dos Santos; Juan Moises Zonis; Daniel Gomes de Alvarenga; Rodrigo Assunção de Holanda; Jaqueline Gontijo de Sousa; Kênia Valéria Dos Santos; Maria Aparecida de Resende Stoianoff Journal: BMC Infect Dis Date: 2016-02-23 Impact factor: 3.090