Literature DB >> 20007299

Dynamics and heterogeneity in the process of human frailty and aging: evidence from the U.S. older adult population.

Yang Yang1, Linda C Lee.   

Abstract

OBJECTIVES: This study investigated the dynamics and heterogeneity of the frailty index (FI) conceived as a systemic indicator of biological aging in the community-dwelling older adult population in the United States.
METHODS: We used panel data on multiple birth cohorts from the Health and Retirement Survey 1993-2006 and growth curve models to estimate age trajectories of the FI and their differences by sex, race, and socioeconomic status (SES) within cohorts.
RESULTS: The FI for cohorts born before 1942 exhibit quadratic increases with age and accelerated increases in the accumulation of health deficits. More recent cohorts exhibit higher average levels of and rates of increment in the FI than their predecessors do at the same ages. Females, non-Whites, and individuals with low education and income exhibit greater degrees of physiological deregulation than their male, White, and high-SES counterparts at any age. Patterns of sex, race, and SES differentials in rates of aging vary across cohorts. DISCUSSION: Adjusting for social behavioral factors, the analysis provides evidence for physiological differences in the aging process among recent cohorts of older adults, points to the need for biological explanations of female excess in general system damage, and reveals the insufficiency of any single mechanism for depicting the racial and SES differences in the process of physiological deterioration.

Entities:  

Mesh:

Year:  2009        PMID: 20007299      PMCID: PMC2981448          DOI: 10.1093/geronb/gbp102

Source DB:  PubMed          Journal:  J Gerontol B Psychol Sci Soc Sci        ISSN: 1079-5014            Impact factor:   4.077


  30 in total

Review 1.  Conceptualisation and measurement of frailty in elderly people.

Authors:  K Rockwood; D B Hogan; C MacKnight
Journal:  Drugs Aging       Date:  2000-10       Impact factor: 3.923

2.  Tests for linkage of multiple cohorts in an accelerated longitudinal design.

Authors:  Y Miyazaki; S W Raudenbush
Journal:  Psychol Methods       Date:  2000-03

Review 3.  A conceptual framework of frailty: a review.

Authors:  Walter M Bortz
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2002-05       Impact factor: 6.053

Review 4.  Inflammatory exposure and historical changes in human life-spans.

Authors:  Caleb E Finch; Eileen M Crimmins
Journal:  Science       Date:  2004-09-17       Impact factor: 47.728

Review 5.  Untangling the concepts of disability, frailty, and comorbidity: implications for improved targeting and care.

Authors:  Linda P Fried; Luigi Ferrucci; Jonathan Darer; Jeff D Williamson; Gerard Anderson
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2004-03       Impact factor: 6.053

6.  The mortality rate as a function of accumulated deficits in a frailty index.

Authors:  Arnold B Mitnitski; Alexander J Mogilner; Chris MacKnight; Kenneth Rockwood
Journal:  Mech Ageing Dev       Date:  2002-09       Impact factor: 5.432

7.  Allostatic load as a marker of cumulative biological risk: MacArthur studies of successful aging.

Authors:  T E Seeman; B S McEwen; J W Rowe; B H Singer
Journal:  Proc Natl Acad Sci U S A       Date:  2001-04-03       Impact factor: 11.205

8.  Sex differences in human biological aging.

Authors:  Eitaro Nakamura; Kenji Miyao
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2008-09       Impact factor: 6.053

9.  Sex-specific health deterioration and mortality: the morbidity-mortality paradox over age and time.

Authors:  Alexander M Kulminski; Irina V Culminskaya; Svetlana V Ukraintseva; Konstantin G Arbeev; Kenneth C Land; Anatoli I Yashin
Journal:  Exp Gerontol       Date:  2008-09-20       Impact factor: 4.032

10.  The estimation of relative fitness and frailty in community-dwelling older adults using self-report data.

Authors:  Arnold B Mitnitski; Xiaowei Song; Kenneth Rockwood
Journal:  J Gerontol A Biol Sci Med Sci       Date:  2004-06       Impact factor: 6.053

View more
  55 in total

1.  Modeling disability trajectories and mortality of the oldest-old in China.

Authors:  Zachary Zimmer; Linda G Martin; Daniel S Nagin; Bobby L Jones
Journal:  Demography       Date:  2012-02

2.  The frailty index in Europeans: association with age and mortality.

Authors:  Roman Romero-Ortuno; Rose Anne Kenny
Journal:  Age Ageing       Date:  2012-04-19       Impact factor: 10.668

3.  Foundations of Activity of Daily Living Trajectories of Older Americans.

Authors:  Linda G Martin; Zachary Zimmer; Jinkook Lee
Journal:  J Gerontol B Psychol Sci Soc Sci       Date:  2015-09-02       Impact factor: 4.077

4.  Age, period and cohort effects on adult body mass index and overweight from 1991 to 2009 in China: the China Health and Nutrition Survey.

Authors:  Lindsay M Jaacks; Penny Gordon-Larsen; Elizabeth J Mayer-Davis; Linda S Adair; Barry Popkin
Journal:  Int J Epidemiol       Date:  2013-06-14       Impact factor: 7.196

5.  Measurement of organ structure and function enhances understanding of the physiological basis of frailty: the Cardiovascular Health Study.

Authors:  Jason L Sanders; Robert M Boudreau; Linda P Fried; Jeremy D Walston; Tamara B Harris; Anne B Newman
Journal:  J Am Geriatr Soc       Date:  2011-08-24       Impact factor: 5.562

6.  Race/Ethnic Differentials in the Health Consequences of Caring for Grandchildren for Grandparents.

Authors:  Feinian Chen; Christine A Mair; Luoman Bao; Yang Claire Yang
Journal:  J Gerontol B Psychol Sci Soc Sci       Date:  2014-12-06       Impact factor: 4.077

7.  Disability Trajectories at the End of Life: A "Countdown" Model.

Authors:  Douglas A Wolf; Vicki A Freedman; Jan I Ondrich; Christopher L Seplaki; Brenda C Spillman
Journal:  J Gerontol B Psychol Sci Soc Sci       Date:  2015-03-03       Impact factor: 4.077

8.  Alternative Retirement Paths and Cognitive Performance: Exploring the Role of Preretirement Job Complexity.

Authors:  Dawn C Carr; Robert Willis; Ben Lennox Kail; Laura L Carstensen
Journal:  Gerontologist       Date:  2020-04-02

9.  Genes Related to Education Predict Frailty Among Older Adults in the United States.

Authors:  Brooke M Huibregtse; Breanne L Newell-Stamper; Benjamin W Domingue; Jason D Boardman
Journal:  J Gerontol B Psychol Sci Soc Sci       Date:  2021-01-01       Impact factor: 4.077

10.  Promoting access to innovation for frail old persons. IAGG (International Association of Gerontology and Geriatrics), WHO (World Health Organization) and SFGG (Société Française de Gériatrie et de Gérontologie) Workshop--Athens January 20-21, 2012.

Authors:  G Berrut; S Andrieu; I Araujo de Carvalho; J P Baeyens; H Bergman; B Cassim; F Cerreta; M Cesari; H B Cha; L K Chen; A Cherubini; M Y Chou; A J Cruz-Jentoft; L De Decker; P Du; B Forette; F Forette; A Franco; R Guimaraes; L M Guttierrez-Robledo; J Jauregui; V Khavinson; W J Lee; L N Peng; C Perret-Guillaume; M Petrovic; F Retornaz; K Rockwood; L Rodriguez-Manas; C Sieber; G Spatharakis; O Theou; E Topinkova; B Vellas; A Benetos
Journal:  J Nutr Health Aging       Date:  2013       Impact factor: 4.075

View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.