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Literature DB >> 20004043

Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety.

B Chandrakantha¹, Prakash Shetty, Vijesh Nambiyar, Nishitha Isloor, Arun M Isloor.

Abstract

In the present study a series of new 1,3,4-oxadiazole derivatives containing 2-fluoro-4-methoxy moiety were synthesized. These newly synthesized compounds were characterized by NMR, mass spectral, IR spectral study and also by C, H, N analyses. All the newly synthesized compounds were screened for their antibacterial and antifungal studies. Antimicrobial studies revealed that compounds 4a and 4b showed significant antibacterial activity against Escherichia coli and Pseudomonas aeruginosa Compound 4i showed significant antifungal activity against C. albicans. Copyright (c) 2009 Elsevier Masson SAS. All rights reserved.

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Year: 2009 PMID： 20004043 DOI： 10.1016/j.ejmech.2009.11.046

Source DB: PubMed Journal: Eur J Med Chem ISSN： 0223-5234 Impact factor: 6.514

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Cited

15 in total

1. Synthesis, X-ray crystal structures and optical properties of novel substituted pyrazoly 1,3,4-oxadiazole derivatives.

Authors: Hong-Shui Lv; Yong-Sheng Xie; Wei-Yong Liu; Zhong-Liang Gong; Bao-Xiang Zhao
Journal: J Fluoresc Date: 2011-03-05 Impact factor: 2.217

9. In-silico docking based design and synthesis of [1H,3H] imidazo[4,5-b] pyridines as lumazine synthase inhibitors for their effective antimicrobial activity.

Authors: Sunil L Harer; Manish S Bhatia
Journal: J Pharm Bioallied Sci Date: 2014-10

10. Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids.

Authors: Mohammad F Hassan; Abdul Rauf; Asif Sherwani; Mohammad Owais
Journal: Sci Pharm Date: 2015-06-09

Synthesis, characterization and biological activity of some new 1,3,4-oxadiazole bearing 2-flouro-4-methoxy phenyl moiety.

1. Synthesis, X-ray crystal structures and optical properties of novel substituted pyrazoly 1,3,4-oxadiazole derivatives.

Review 2. 1,3,4-Oxadiazole Derivatives. Optical Properties in Pure and Mixed Solvents.

3. 5-(2,4-Dichloro-phen-yl)-3-(4-nitro-phen-yl)-1,2,4-oxadiazole.

4. 2-Methyl-5-[(3-methyl-4-nitro-benz-yl)sulfan-yl]-1,3,4-thia-diazole.

5. 3-(2,4-Dichloro-phen-yl)-5-phenyl-1,2,4-oxadiazole.

6. 5-[(4-Meth-oxy-benz-yl)sulfan-yl]-2-methyl-1,3,4-thia-diazole.

7. 4-(3-Chloro-phen-yl)-3-[(2,6-difluoro-benz-yl)sulfan-yl]-5-(3,4,5-trimeth-oxy-phen-yl)-4H-1,2,4-triazole.

8. Synthesis and In Vitro Antimicrobial Evaluation of New 1,3,4-Oxadiazoles Bearing 5-Chloro-2-methoxyphenyl Moiety.

9. In-silico docking based design and synthesis of [1H,3H] imidazo[4,5-b] pyridines as lumazine synthase inhibitors for their effective antimicrobial activity.

10. Synthesis and In Vitro Biological Evaluation of 1,3,4-Oxadiazol-2(3H)-one and Tetrahydropyridazine-3,6-dione Derivatives of Fatty Acids.