Literature DB >> 199831

Hepatitis A-virus particles in stools of patients from a natural hepatitis outbreak in Germany.

B Flehmig, H Frank, G G Frösner, H J Gerth.   

Abstract

During a hepatitis outbreak in Southern Germany 27 nm particles were visualized by immune electron microscopy in stools of two patients. These particles were sereologically identical or similar to hepatitis A-virus particles identified in the USA. The buoyant density of these particles was 1.34 g/cm3 as shown by cesium chloride density centrifugation. The particles were first observed in small numbers in a stool obtained 11 days, and in large numbers in stools obtained 6 and 7 days before the onset of jaundice. Few particles were seen on the day of the onset of jaundice and none thereafter. In both patients a sereoconversion to hepatitis A-virus as judged by immune electron microscopy could be demonstrated.

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Year:  1977        PMID： 199831     DOI： 10.1007/bf02126679

Source DB:  PubMed          Journal:  Med Microbiol Immunol        ISSN： 0300-8584            Impact factor:   3.402


  12 in total

1.  CsCl banding of hepatitis A-associated virus-like particles.

Authors:  D W Bradley; C L Hornbeck; E H Cood; J E Maynard; C R Gravelle
Journal:  J Infect Dis       Date:  1975-03       Impact factor: 5.226

2.  A specific complement-fixation test for human hepatitis a employing CR326 virus antigen. Diagnosis and epidemiology.

Authors:  P J Provost; O L Ittensohn; V M Villarejos; M R Hilleman
Journal:  Proc Soc Exp Biol Med       Date:  1975-04

3.  Comparison of serological tests for antibody to hepatitis A antigen, using coded specimens from individuals infected with the MS-1 strain of hepatitis A virus.

Authors:  J L Dienstag; S Krugman; D C Wong; R H Purcell
Journal:  Infect Immun       Date:  1976-10       Impact factor: 3.441

4.  Hepatitis-A antigen in Edinburgh.

Authors:  R Hopkins; T G Scott
Journal:  Lancet       Date:  1976-07-24       Impact factor: 79.321

5.  Detection of hepatitis A viral antigen by radioimmunoassay.

Authors:  F B Hollinger; D W Bradley; J E Maynard; G R Dreesman; J L Melnick
Journal:  J Immunol       Date:  1975-11       Impact factor: 5.422

6.  A microtiter solid-phase radioimmunoassay for hepatitis A antigen and antibody.

Authors:  R H Purcell; D C Wong; Y Moritsugu; J L Dienstag; J A Routenberg; J D Boggs
Journal:  J Immunol       Date:  1976-02       Impact factor: 5.422

7.  Hepatitis A: report of a common-source outbreak with recovery of a possible etiologic agent. II. Laboratory studies.

Authors:  C R Gravelle; C L Hornbeck; J E Maynard; C A Schable; E H Cook; D W Bradley
Journal:  J Infect Dis       Date:  1975-02       Impact factor: 5.226

8.  Hepatitis A: detection by immune electron microscopy of a viruslike antigen associated with acute illness.

Authors:  S M Feinstone; A Z Kapikian; R H Purceli
Journal:  Science       Date:  1973-12-07       Impact factor: 47.728

9.  Faecal shedding of hepatitis-A antigen.

Authors:  J L Dienstag; S M Feinstone; A Z Kapikian; R H Purcell
Journal:  Lancet       Date:  1975-04-05       Impact factor: 79.321

10.  Hepatitis A antigen particles in liver, bile, and stool of chimpanzees.

Authors:  A N Schulman; J L Dienstag; D R Jackson; J H Hoofnagle; R J Gerety; R H Purcell; L F Barker
Journal:  J Infect Dis       Date:  1976-07       Impact factor: 5.226
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  8 in total

1.  Application of a solid-phase radioimmunoassay and immune electron microscopy for hepatitis A in diagnosis and research.

Authors:  B Flehmig; M Ranke; H Frank; H J Gerth
Journal:  Med Microbiol Immunol       Date:  1978-11-17       Impact factor: 3.402

2.  Hepatitis A virus inhibits cellular antiviral defense mechanisms induced by double-stranded RNA.

Authors:  Kerstin Brack; Iris Berk; Thomas Magulski; Jörg Lederer; Andreas Dotzauer; Angelika Vallbracht
Journal:  J Virol       Date:  2002-12       Impact factor: 5.103

3.  Hepatitis A-virus in cell culture. IV. Comparison of cell-culture-produced HAV with stool-derived HAV in diagnostic test systems.

Authors:  B Flehmig; M Pfisterer; A Vallbracht
Journal:  Med Microbiol Immunol       Date:  1984       Impact factor: 3.402

4.  Detection of hepatitis A virus in the stools of healthy people from endemic areas.

Authors:  P De Filippis; M Divizia; A Mele; B Adamo; A Panà
Journal:  Eur J Epidemiol       Date:  1987-06       Impact factor: 8.082

5.  Hepatitis A virus suppresses RIG-I-mediated IRF-3 activation to block induction of beta interferon.

Authors:  Volker Fensterl; Dajana Grotheer; Iris Berk; Stefanie Schlemminger; Angelika Vallbracht; Andreas Dotzauer
Journal:  J Virol       Date:  2005-09       Impact factor: 5.103

6.  Hepatitis A-virus in cell culture: I. propagation of different hepatitis A-virus isolates in a fetal rhesus monkey kidney cell line (Frhk-4).

Authors:  B Flehmig
Journal:  Med Microbiol Immunol       Date:  1980       Impact factor: 3.402

7.  Nucleotide sequence of wild-type hepatitis A virus GBM in comparison with two cell culture-adapted variants.

Authors:  J Graff; A Normann; S M Feinstone; B Flehmig
Journal:  J Virol       Date:  1994-01       Impact factor: 5.103

8.  Glomerulonephritis associated with arteritis in marmosets infected with hepatitis A virus.

Authors:  M Morita; K Kitajima; H Yoshizawa; Y Itoh; S Iwakiri; C Shibata; M Mayumi
Journal:  Br J Exp Pathol       Date:  1981-02
  8 in total

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