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Literature DB >> 1997377

Fragile sites and chromosome instability: the distribution of breaks induced by cis-diamine-dichloro-platinum (II) in Fanconi anemia lymphocyte cultures.

B Porfirio¹, D Smeets, L Beckers, D Caporossi, B Tedeschi, P Vernole, H Joenje, B Nicoletti, B Dallapiccola.

Abstract

The distribution of chromosome breaks induced by the antitumor drug cis-diamine-dichloroplatinum (II) in lymphocyte cultures from Fanconi anemia patients was analyzed. Breakpoints occurred nonrandomly over an arbitrarily defined human karyotype of 319 bands. These bands were classified according to either their banding pattern or their fragile site status (whether or not a fragile site of a given type is located at a chromosomal band). A significant involvement of G-light and fragile site bands was detected. The preferential occurrence of breaks at fragile site bands was limited to common fragile site bands (essentially of the aphidicolin-type).

Entities: Chemical Disease Species

Mesh：

Substances：
Cisplatin

Year: 1991 PMID： 1997377 DOI： 10.1007/bf00202404

Source DB: PubMed Journal: Hum Genet ISSN： 0340-6717 Impact factor: 4.132

24 in total

1. Distribution of spontaneous chromosome breaks in human chromosomes.

Authors: P Aula; H von Koskull
Journal: Hum Genet Date: 1976-05-19 Impact factor: 4.132

Review 2. Multiple recurrent genomic rearrangements and fragile sites in human cancer.

Authors: J J Yunis
Journal: Somat Cell Mol Genet Date: 1987-07

3. The distribution of MspI-induced breaks in human lymphocyte chromosomes and its relationship to common fragile sites.

Authors: B Porfirio; B Tedeschi; P Vernole; D Caporossi; B Nicoletti
Journal: Mutat Res Date: 1989-08 Impact factor: 2.433

4. Fragile sites update.

Authors: F Hecht
Journal: Cancer Genet Cytogenet Date: 1988-03

5. Chi-squared tests with small numbers.

Authors: C A Smith
Journal: Ann Hum Genet Date: 1986-05 Impact factor: 1.670

6. Nonrandom distribution of chromosome breaks in Fanconi's anemia.

Authors: H Von Koskull; P Aula
Journal: Cytogenet Cell Genet Date: 1973

Review 7. Mechanisms of chromosome banding and implications for chromosome structure.

Authors: D E Comings
Journal: Annu Rev Genet Date: 1978 Impact factor: 16.830

8. Differential sensitivity of Fanconi anaemia lymphocytes to the clastogenic action of cis-diamminedichloroplatinum (II) and trans-diamminedichloroplatinum (II).

Authors: E H Poll; F Arwert; H Joenje; A H Wanamarta
Journal: Hum Genet Date: 1985 Impact factor: 4.132

9. DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes.

Authors: T W Glover; C Berger; J Coyle; B Echo
Journal: Hum Genet Date: 1984 Impact factor: 4.132

10. An international system for human cytogenetic nomenclature--high-resolution banding (1981). ISCN (1981). Report of the Standing Committee on Human Cytogenetic Nomenclature.

Authors:
Journal: Cytogenet Cell Genet Date: 1981

6 in total

Fragile sites and chromosome instability: the distribution of breaks induced by cis-diamine-dichloro-platinum (II) in Fanconi anemia lymphocyte cultures.

1. Distribution of spontaneous chromosome breaks in human chromosomes.

Review 2. Multiple recurrent genomic rearrangements and fragile sites in human cancer.

3. The distribution of MspI-induced breaks in human lymphocyte chromosomes and its relationship to common fragile sites.

4. Fragile sites update.

5. Chi-squared tests with small numbers.

6. Nonrandom distribution of chromosome breaks in Fanconi's anemia.

Review 7. Mechanisms of chromosome banding and implications for chromosome structure.

8. Differential sensitivity of Fanconi anaemia lymphocytes to the clastogenic action of cis-diamminedichloroplatinum (II) and trans-diamminedichloroplatinum (II).

9. DNA polymerase alpha inhibition by aphidicolin induces gaps and breaks at common fragile sites in human chromosomes.

10. An international system for human cytogenetic nomenclature--high-resolution banding (1981). ISCN (1981). Report of the Standing Committee on Human Cytogenetic Nomenclature.

Review 1. Molecular pathogenesis and clinical management of Fanconi anemia.

2. Localization of the Fanconi anemia complementation group D gene to a 200-kb region on chromosome 3p25.3.

Review 3. Expanded roles of the Fanconi anemia pathway in preserving genomic stability.

4. The FANC pathway and BLM collaborate during mitosis to prevent micro-nucleation and chromosome abnormalities.

Review 5. Rescue from replication stress during mitosis.

6. Rev3, the catalytic subunit of Polζ, is required for maintaining fragile site stability in human cells.