Literature DB >> 2474762

The distribution of MspI-induced breaks in human lymphocyte chromosomes and its relationship to common fragile sites.

B Porfirio1, B Tedeschi, P Vernole, D Caporossi, B Nicoletti.   

Abstract

The restriction endonuclease MspI (cleavage site C/CGG) induces chromosomal breaks in human lymphocytes. The breakpoints are distributed non-randomly along the chromosomes and the pattern of MspI-induced breakage depends on the recovery time (20 h or 6 h). Chromosomal bands preferentially involved in breakage are likely to coincide with bands where common fragile sites are located.

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Year:  1989        PMID： 2474762     DOI： 10.1016/0027-5107(89)90142-5

Source DB:  PubMed          Journal:  Mutat Res        ISSN： 0027-5107            Impact factor:   2.433


  4 in total

1.  Population cytogenetics of aphidicolin-induced fragile sites.

Authors:  B Tedeschi; P Vernole; M L Sanna; B Nicoletti
Journal:  Hum Genet       Date:  1992-07       Impact factor: 4.132

Review 2.  Chromosome bands, their chromatin flavors, and their functional features.

Authors:  G P Holmquist
Journal:  Am J Hum Genet       Date:  1992-07       Impact factor: 11.025

3.  The enigma of common fragile sites.

Authors:  I Simonic; G S Gericke
Journal:  Hum Genet       Date:  1996-04       Impact factor: 4.132

4.  Fragile sites and chromosome instability: the distribution of breaks induced by cis-diamine-dichloro-platinum (II) in Fanconi anemia lymphocyte cultures.

Authors:  B Porfirio; D Smeets; L Beckers; D Caporossi; B Tedeschi; P Vernole; H Joenje; B Nicoletti; B Dallapiccola
Journal:  Hum Genet       Date:  1991-01       Impact factor: 4.132
  4 in total

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