Warning: Undefined array key "mm" in /www/wwwroot/www.ai-bt.com/si.php on line 10 Deprecated: trim(): Passing null to parameter #1 ($string) of type string is deprecated in /www/wwwroot/www.ai-bt.com/si.php on line 10 Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.

Literature DB >> 1997101

Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.

E A Lindsay¹, M C Berenbaum, R Bonnett, D G Thomas.

Abstract

Subcutaneous and intracranial VMDk tumours were treated with photodynamic therapy (PDT) using a new sensitiser, m-THPP. Subcutaneous tumours were highly sensitive to PDT but intracranial tumours were much more resistant, requiring a 30-fold increase in sensitiser dose to produce equivalent levels of necrosis. Resistance of intracerebral tumours was not due to failure of the sensitiser to enter tumours. Necrosis of intracranial tumours was increased when mice breathed 100% oxygen during PDT while subcutaneous tumour necrosis was unaffected.

Entities: Chemical Disease Species

Mesh：

Substances：

Year: 1991 PMID： 1997101 PMCID： PMC1971766 DOI： 10.1038/bjc.1991.57

Source DB: PubMed Journal: Br J Cancer ISSN： 0007-0920 Impact factor: 7.640

19 in total

1. Astrocytomas in an inbred mouse strain.

Authors: H Fraser
Journal: J Pathol Date: 1971-04 Impact factor: 7.996

2. Optical properties of human brain.

Authors: L O Svaasand; R Ellingsen
Journal: Photochem Photobiol Date: 1983-09 Impact factor: 3.421

Review 3. A pharmacologic basis for brain tumor chemotherapy.

Authors: V A Levin
Journal: Semin Oncol Date: 1975-03 Impact factor: 4.929

4. Photoradiation therapy in the treatment of malignant brain tumors: a phase I (feasibility) study.

Authors: E R Laws; D A Cortese; J H Kinsey; R T Eagan; R E Anderson
Journal: Neurosurgery Date: 1981-12 Impact factor: 4.654

5. The development of an animal model of glioma for use in experimental neuro-oncology.

Authors: R Bradford; J L Darling; D G Thomas
Journal: Br J Neurosurg Date: 1989 Impact factor: 1.596

6. Survival in glioblastoma: historical perspective.

Authors: M Salcman
Journal: Neurosurgery Date: 1980-11 Impact factor: 4.654

7. Development of a protocol for photoradiation therapy of malignant brain tumors: part 1. Photosensitization of normal brain tissue with hematoporphyrin derivative.

Authors: D E Rounds; S Jacques; C H Shelden; C A Shaller; R S Olson
Journal: Neurosurgery Date: 1982-10 Impact factor: 4.654

Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.

1. Astrocytomas in an inbred mouse strain.

2. Optical properties of human brain.

Review 3. A pharmacologic basis for brain tumor chemotherapy.

4. Photoradiation therapy in the treatment of malignant brain tumors: a phase I (feasibility) study.

5. The development of an animal model of glioma for use in experimental neuro-oncology.

6. Survival in glioblastoma: historical perspective.

7. Development of a protocol for photoradiation therapy of malignant brain tumors: part 1. Photosensitization of normal brain tissue with hematoporphyrin derivative.

8. Fast attempts at the photodynamic treatment of human gliomas.

9. The mechanism of photodynamic inactivation of human cells in vitro in the presence of haematoporphyrin.

10. In vivo biological activity of the components of haematoporphyrin derivative.

1. Subcutaneous Xenograft Models for Studying PDT In Vivo.

2. The sensitivity of normal brain and intracranially implanted VX2 tumour to interstitial photodynamic therapy.

Review 3. Animal models for photodynamic therapy (PDT).