Literature DB >> 2803583

The development of an animal model of glioma for use in experimental neuro-oncology.

R Bradford1, J L Darling, D G Thomas.   

Abstract

A cell line, 497-P(1), derived from the VM spontaneous murine astrocytoma has been used to develop an in vitro in vivo model of human glioma. This paper describes the growth characteristics of tumours produced after intracerebral or subcutaneous inoculation of 497-P(1) cells into syngeneic VM mice. The results show that cell line 497-P(1) provides the basis for a reproducible animal model of glioma which fulfils many of the criteria required for experimental therapy studies.

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Year:  1989        PMID： 2803583     DOI： 10.3109/02688698909002795

Source DB:  PubMed          Journal:  Br J Neurosurg        ISSN： 0268-8697            Impact factor:   1.596


  6 in total

1.  The VM model of glioma: preparation of multicellular tumour spheroids (MTS) and their response to chemotherapy.

Authors:  R Bradford; J L Darling; N Sier; D G Thomas
Journal:  J Neurooncol       Date:  1990-10       Impact factor: 4.130

2.  Heterogeneity of chemosensitivity in six clonal cell lines derived from a spontaneous murine astrocytoma and its relationship to genotypic and phenotypic characteristics.

Authors:  R Bradford; H Koppel; G J Pilkington; D G Thomas; J L Darling
Journal:  J Neurooncol       Date:  1997-09       Impact factor: 4.130

Review 3.  Image-guided 1H NMR spectroscopical and histological characterization of a human brain tumor model in the nude rat; a new approach to monitor changes in tumor metabolism.

Authors:  H J Bernsen; A Heerschap; A J van der Kogel; J J van Vaals; M J Prick; E F Poels; J Meyer; J A Grotenhuis
Journal:  J Neurooncol       Date:  1992-06       Impact factor: 4.130

4.  Therapeutic effects of Holmium-166 chitosan complex in rat brain tumor model.

Authors:  Ryoong Huh; Yong Sook Park; Jong Doo Lee; Young Sun Chung; Yong Gou Park; Sang Sup Chung; Jin Woo Chang
Journal:  Yonsei Med J       Date:  2005-02-28       Impact factor: 2.759

5.  Photodynamic therapy of a mouse glioma: intracranial tumours are resistant while subcutaneous tumours are sensitive.

Authors:  E A Lindsay; M C Berenbaum; R Bonnett; D G Thomas
Journal:  Br J Cancer       Date:  1991-02       Impact factor: 7.640

6.  The chemotherapeutic response of a murine (VM) model of human glioma.

Authors:  R Bradford; J L Darling; D G Thomas
Journal:  Br J Cancer       Date:  1990-01       Impact factor: 7.640
  6 in total

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