Measuring the impact of cancer: a comparison of non-Hodgkin lymphoma and breast cancer survivors.

INTRODUCTION: Self-report instruments such as the Impact of Cancer (IOC) are designed to measure quality of life (QOL) impacts that cancer survivors attribute to their cancer experience. Generalizability of QOL findings across distinct diagnostic categories of survivors is untested. We compare measurement of the impact of cancer using the IOC instrument in breast cancer (BC) survivors (n = 1,188) and non-Hodgkin lymphoma (NHL) survivors (n = 652).
METHODS: A registry-based sample of NHL survivors completed the IOC questionnaire and the FACT-G, FACT-LYM, Medical Outcomes Study (MOS) SF-36, Post-Traumatic Stress Disorder Checklist-Civilian Version, Post-Traumatic Growth Inventory and MOS Social Support scales. IOC responses of the NHL survivors were subjected to de novo scaling to identify impact domains for comparison to IOC version 2 (IOCv2) domains, which were previously developed based on BC survivor responses. Concurrent validity was assessed by correlating the IOCv2 scales with the other measures. IOCv2 scores were compared between the BC and NHL survivor samples.
RESULTS: The BC and NHL survivors exhibited similar impact domains and had factor structures that were largely congruent. The concurrent validity analysis revealed patterns of association that supported the interpretation and validity of the IOCv2 scales. Differences in IOCv2 scores between the BC and NHL groups suggested differential impacts in distinct survivor groups that could be detected using the IOCv2.
CONCLUSION: The results suggest that the IOCv2 measures common and important survivor concerns and support its generalizability to the broader long-term cancer survivor population. IMPLICATIONS FOR CANCER SURVIVORS: Instruments such as the IOCv2 can provide valid assessment of QOL impacts in long-term cancer survivors, facilitating the characterization of these impacts and development of appropriate interventions.

Introduction

There is a large and growing population of cancer survivors [1], with an expanding literature documenting impacts of cancer among survivors across physical, psychological, emotional, social and spiritual domains [2-6]. The need for research on health-related quality of life (HRQOL) in this growing at-risk population was recently highlighted by the Institute of Medicine [7]. Valid assessment of HRQOL in cancer survivors is a prerequisite for characterizing and monitoring these impacts and developing appropriate interventions. However, standardized measures of HRQOL often fail to address the unique concerns reported by long-term survivors. For example, many survivors experience health and body image concerns that are specifically cancer-related [8-10]. In addition, research with cancer patients has increasingly recognized that a large proportion report positive life changes or personal growth as a result of their illness, a construct referred to as benefit finding [11-16]. Generic HRQOL measures are generally not designed to capture these domains. This has created a need to develop targeted instruments measuring domains important to the well-being of cancer survivors [17-20].

Several instruments have been developed specifically to measure the concerns of long-term cancer survivors. An early example is the Quality of Life-Cancer Survivors (QOL-CS) scale [21], an instrument adapted from existing broad-based HRQOL instruments composed predominantly of generic items. The Quality of Life in Adult Cancer Survivors (QLACS) scale [22, 23] is a more recent instrument covering five cancer-specific domains (Financial Problems, Benefits, Distress-Family, Appearance, Distress-Recurrence) and seven generic domains (Negative Feelings, Positive Feelings, Cognitive Problems, Pain, Sexual Interest, Energy/Fatigue, Sexual Function, Social Avoidance). Targeted, construct-specific instruments for cancer survivors have also been developed. For example, the Breast Cancer Prevention Trial (BCPT) Symptom Checklist assesses physical effects of medical intervention to prevent and treat breast cancer [24, 25], and several scales measure fear of cancer recurrence [26, 27]. Construct-specific scales such as these are generally designed to serve as adjuncts to, or modules in, other HRQOL instruments.

With the goal of developing a comprehensive instrument specifically designed to measure HRQOL impacts that long-term survivors ascribe to their cancer experience and with funding from the National Cancer Institute’s Office of Cancer Survivorship, members of our group and others have developed the Impact of Cancer (IOC) scale [28-30]. The IOC measures both negative impacts and the positive life changes reported by many survivors, such as a finding of meaning or purpose, which generic HRQOL instruments are generally not designed to capture [31-33]. The IOC was developed through a standard psychometric approach (qualitative interviews with long-term survivors for item generation followed by item reduction, cognitive testing and additional reduction to a pool of 81 items), leading to an initial scale identification using data from 193 survivors of breast, prostate, colorectal and lymphatic cancers [28, 29]. Recently, more comprehensive scaling using data from 1,188 breast cancer (BC) survivors was conducted [30]. This effort included de novo scaling of the 81-item pool, split-sample cross-validation and evaluation of internal consistency and construct and concurrent validity, yielding the Impact of Cancer version 2 (IOCv2) scales (instrument available from the first author) [30], with 37 items composing positive and negative summary scales (including eight subscales) and 10 items measuring employment and relationship concerns.

To be widely useful, instruments measuring HRQOL in cancer survivors must be valid across different cancer diagnoses. The IOCv2 scales demonstrated excellent internal consistency and validity, but proof of their generalizability is limited due to testing only in female BC survivors who were 5–10 years post-diagnosis. Would these same scales be confirmed among survivors with a different cancer diagnosis, gender distribution and treatment trajectory? In particular, would another survivor group identify similar impact domains and have scale scores that are equally valid measurements of the underlying constructs? Investigation of these issues is necessary to establish reliable and well-validated scales to measure the psychosocial impacts of cancer across the spectrum of diagnoses and survivorship stages. This study was undertaken to examine the reliability and validity of the IOCv2 scales in an independent sample of 652 disease-free non-Hodgkin lymphoma (NHL) survivors, and to compare results for the BC and NHL survivors to evaluate the generalizability of the IOCv2 across survivor samples.

Participants and methods

Participants

NHL survivors were identified through the Duke University and University of North Carolina at Chapel Hill Lineberger tumor registries in November 2004 as previously described [34]. Patients were eligible if diagnosed with NHL,≥19 years old at diagnosis, and ≥2 years post-diagnosis. Prospective participants were mailed a self-administered survey that included the 81 IOC items and other measures described below. Of the 1195 eligible survivors who were assumed to have received a mailed survey, 886 (74%) returned survey materials. Participating survivors were less frequently African American and older at diagnosis and study enrollment [34]. Patients reporting active disease or with unknown recurrence status (n = 234) were excluded to limit the analysis to disease-free survivors.

The BC survivors were members of the Life After Cancer Epidemiology cohort [35], recruited primarily from the Kaiser Permanente Northern California and Utah cancer registries. Patients were eligible if they were diagnosed at age 18–79 with a primary breast cancer (Stage 1 ≥ 1 cm, 2, 2A) within 39 months of enrollment, had no history of other cancer within five years of enrollment, had completed treatment (except for adjuvant hormonal therapy), and were recurrence-free at enrollment. Of 5656 women presumed to meet the LACE eligibility criteria, 2614 (46%) agreed to participate. Responders were closer to their diagnosis date and older than nonresponders but did not differ in severity of cancer or treatment [35]. Subsequent review resulted in 293 exclusions. Participants completed the 81 IOC items as part of a mailed self-administered resurvey April 2006–January 2007. The IOC questionnaire was returned by 1286 of 1805 women (71%). Respondents were older at diagnosis and enrollment, more likely to be white, and had higher levels of education than nonrespondents [30]. Women with recurrent or new primary disease or unknown status in this regard were excluded from our study sample (n = 98).

Institutional review board approval was obtained at all institutions participating in the study and written informed consent was obtained from each participant.

Measures

The full IOC questionnaire [28] comprises 81 items that present statements regarding specific impacts of cancer to which respondents indicate their level of agreement from 1 (strongly disagree) to 5 (strongly agree). Seventy items apply to all survivors, 3 to currently employed respondents, 4 to respondents not currently partnered, and 4 to currently partnered respondents. The IOCv2, a scaled instrument using 47 of these items [30] is provided in the appendix online.

The Functional Assessment of Cancer Therapy: General (FACT-G) is a general HRQOL measure for patients receiving cancer treatment that yields a total score and subscales for physical, functional, social/family and emotional well-being [36]. FACT-LYM is a diagnosis-specific measure for NHL patients [37].

The Medical Outcomes Study (MOS) SF-36 is a generic patient-assessed health outcome measure yielding eight subscales and physical and mental health summary scores [38].

The Post-Traumatic Stress Disorder Checklist–Civilian Version (PCL-C) presents a self-report symptom checklist that mirrors criteria for a formal diagnosis of post-traumatic stress disorder [39, 40]. Instructions were modified to key symptoms to lymphoma diagnosis and treatment as the stressor of interest. Survivors rated 17 symptoms on intensity from 1 (not at all) to 5 (extremely bothersome).

The Posttraumatic Growth Inventory (PTGI) assesses positive outcomes reported by persons who have experienced traumatic events and yields a total scale and five subscales [41, 42].

The MOS Social Support Score assesses perceived availability of social support, with a total scale and four subscales pertaining to particular functions served by interpersonal relationships [43].

Statistical analysis

The goals of the analyses were to perform an independent psychometric evaluation of the IOC in the NHL sample and to compare these results with those from the BC survivors. First we conducted a de novo exploratory factor analysis on the NHL survivor data using the 70 IOC items applicable to all survivors, closely mirroring the scaling process previously used for the BC survivor sample [30]. Employment and relationship items, which were scaled separately for the BC sample, were also not included in this factor analysis for the NHL sample. Factors were extracted using principal components, the number of factors was selected using eigenvalue > 1 and scree plots, and promax rotation was performed. After an initial factor analysis, items with factor loadings < 0.50 or not associated with a clearly identifiable factor were dropped and the factor analysis was repeated to produce a set of factors for comparison to the IOCv2 scales obtained from the BC survivor analysis.

Next, we assessed whether the 37-item, 8-factor structure of the IOCv2 positive and negative subscales exhibited by the BC survivors was reproduced in the NHL survivor sample using the targeted rotation method [44], which compares the factor structure of a second sample (NHL survivors) to a reference structure (BC survivors) by extracting the hypothesized number of factors from the second sample and calculating congruence coefficients, which compare two sets of factor loadings in terms of pattern and magnitude [44, 45].

Concurrent validity was evaluated by forming a priori hypotheses about patterns of association and correlating the IOCv2 scores with HRQOL (FACT, SF-36), PCL-C, PTGI and Social Support scores. We hypothesized that the IOCv2 positive scales would be uncorrelated with the HRQOL measures (which are not designed to capture positive impacts) and positively correlated with the PTGI total and subscales (which similarly measure personal growth associated with a traumatic event). We expected an overall pattern of moderate to strong correlation between the IOCv2 negative scales and the HRQOL scales. We hypothesized that the IOCv2 negative summary score would be strongly correlated with aggregate measures of negative impacts (FACT-G, FACT-LYM, SF-36 Physical and Mental, PCL-C Total). We further hypothesized that IOCv2 Body Change Concerns would be correlated with scales measuring physical limitations, that IOCv2 Life Interferences would be correlated with scales measuring functional limitations, and that IOCv2 Worry would be correlated with FACT-G Emotional. We expected IOCv2 Employment Concerns to be moderately correlated with HRQOL measures, and IOCv2 Relationship Concerns to be negatively correlated with the FACT-G Social/Family and Social Support scales.

When evaluating the quantitative significance of correlations, we considered |r| < 0.30 to indicate weak association, 0.30≤|r| < 0.45 moderate, 0.45≤|r| < 0.60 substantial and |r| ≥ 0.60 high [46]. We used P < 0.005 for statistical significance to account for the large sample size and multiple comparisons. All P-values and significance tests were two-sided.

Internal consistency reliability was measured using Cronbach’s alpha [47]. We obtained mean scale scores adjusted for age and years since diagnosis and tested for differences in adjusted means using the SAS GLM procedure. All analyses were conducted using SAS 9.1.

Results

Sample characteristics

The NHL group included similar numbers of men and women, in contrast to the exclusively female BC survivors (Table 1). Comparisons revealed significant differences between the groups on all characteristics except education and income. On average, the BC survivors were diagnosed at an older age and were older at time of survey. Mean interval since diagnosis was longer in the NHL survivors, who also had a broader range of interval. The NHL survivors reported about one more comorbidity on average than the BC group. Despite statistically significant differences in race/ethnicity and marital status, both groups were predominantly white and partnered.

Table 1

Characteristics of the non-Hodgkin lymphoma and breast cancer survivor samples

	NHL survivors		BC survivors		p
Characteristic	No.	%	No.	%
Total No. of respondents	652		1188
Sex					<0.001
Male	329	50
Female	323	50	1188	100
Race					<0.001
White	565	87	958	83
African American	51	8	36	3
Hispanic	9	1	58	5
Asian/Pacific Islander	2	0.3	60	5
Other/more than one	25	4	46	4
Marital status					<0.001
Married/living with partner	518	80	799	68
Widowed/divorced/separated/single	133	20	384	32
Income					0.769
<$60,000	331	56	612	56
≥$60,000	255	44	486	44
Education					0.163
High school or less	179	28	290	24
Some college	205	32	423	36
College graduate or higher	259	40	471	40
Employment					0.015
Employed	263	41	412	35
Retired/unemployed	381	59	763	65
Age, years					<0.001
25–49	115	18	63	5
50–64	235	36	474	40
65–79	237	36	536	45
≥80	65	10	115	10
Mean±SD	62.7 ± 13.5		66.3 ± 10.1		<0.001
Range	25–91		34–89
Age at diagnosis, years					<0.001
19–49	280	43	245	21
50–64	249	38	545	46
65–86	123	19	398	34
Mean±SD	51.9 ± 14.2		58.8 ± 10.1		<0.001
Range	19–86		25–80
Time since diagnosis, years					<0.001
2–5	151	23
5–10	236	36	1188	100
10–20	181	28
≥20	84	13
Mean±SD	10.8±7.5		7.4±0.9		<0.001
Range	2.5–43.6		5.3–9.9
Number of comorbidities					<0.001
0	72	11	270	23
1–2	251	39	548	47
3–5	247	38	295	25
≥6	76	12	59	5
Mean±SD	2.9 ± 2.1		2.0 ± 1.9		<0.001
Range	0–11		0–20

BC breast cancer; NHL non-Hodgkin lymphoma; SD standard deviation.

Tests for differences between the NHL and BC groups were conducted using two-sample t tests, chi-square tests and Fisher exact tests.

De novo factor analysis

Table 2 presents results of the de novo exploratory factor analysis of the IOC items for the NHL sample. Eight domains emerged that were largely congruent with the eight domains found in the IOCv2 scaling on the BC survivor data. In particular, factors for Altruism/Empathy, Health Awareness, Meaning of Cancer, Positive Self-Evaluation, Appearance Concerns and Worry emerged that were either identical to the IOCv2 in item content or differed by one item. Whereas Body Change Concerns and Life Interferences emerged as distinct factors in the BC survivor data, these two constructs emerged as a single factor in the NHL sample. However, all Body Change Concern items in the IOCv2 were also identified in the NHL sample, and five of the seven life interference items in the IOCv2 also appeared in the NHL sample.

Table 2

Comparison of exploratory factor analyses of IOC items for breast cancer and non-Hodgkin lymphoma survivor samples

	Factor loadings from exploratory factor analyses
	BC survivors	NHL survivors
Altruism/Empathy
Having had cancer has made me more willing to help others	0.86	0.89
Because I had cancer I am more understanding of what other people feel	0.80	0.84
I feel a special bond with people with cancer	0.77	0.83
I feel I should give something back to others	0.76	0.86
I place a higher value on my relationships with family or friends than I did before having had cancer		0.63
I learned something about myself because of having had cancer		0.61
Health awareness
Having had cancer has made me more concerned about my health	0.87	0.80
I do not take my body for granted since I had cancer	0.78	0.69
I am more aware of physical problems or changes	0.75	0.76
Having had cancer has made me take better care of myself	0.70	0.62
Meaning of cancer
Because of cancer I have more confidence in myself	0.90	0.84
Having had cancer has given me direction in life	0.86	0.83
Because of cancer I have become better about expressing what I want	0.85	0.85
Because of having had cancer I feel that I have more control of my life	0.72	0.80
Having had cancer turned into a reason to make changes in my life	0.65	0.74
Positive self-evaluation
I consider myself to be a cancer survivor	0.80	0.70
I feel a sense of pride or accomplishment from surviving cancer	0.91	0.66
I feel that I am a role model	0.67	0.58
I learned something about myself because of having had cancer	0.71
Positive outlook
Having had cancer has made me realize that time is precious		0.82
I learned something about life because of having had cancer		0.71
Having had cancer has strengthened my religious faith or sense of spirituality		0.62
Appearance concerns
I worry about how my body looks	0.69	0.82
I feel disfigured	0.86	0.88
I sometimes wear clothing to cover parts of my body	0.82	0.86
Body change concerns*
I am bothered that my body cannot do what it could before	0.94	0.84
I am concerned that my energy has not returned	0.91	0.82
Having had cancer has made me feel old.	0.59	0.76
Life interferences*
Having had cancer has made me feel alone	0.78	0.70
I feel like cancer runs my life	0.74	0.74
Having had cancer has made me feel like some people do not understand me	0.74	0.67
I feel guilty today for not having been available to my family	0.64	0.60
Ongoing symptoms interfere with my life.	0.58	0.84
Uncertainty about my future affects my decisions to make plans	0.79
Having had cancer keeps me from doing activities I enjoy	0.77
My life would be better today if I had not had cancer		0.75
Having to pay attention to my physical health interferes with my life.		0.69
Having had cancer has motivated me to make plans for dying (get my affairs in order)		0.67
I have financial problems that are related to having had cancer.		0.59
Worry
Having had cancer makes me feel uncertain about my health	0.88	0.87
I worry about the future	0.82	0.87
Having had cancer makes me feel unsure about the future	0.81	0.83
I worry about cancer coming back or getting another cancer	0.81	0.85
New symptoms make me worry about cancer coming back	0.77	0.83
I worry about my health	0.76	0.72
I feel like time in my life in running out	0.59	0.57
I am afraid to die.		0.67

BC breast cancer; NHL non-Hodgkin lymphoma

Body change concerns and life interferences emerged as a single domain in the factor analysis on the NHL sample.

The NHL analysis also yielded a three-item scale that did not emerge in the BC sample but which was identical to the Positive Outlook subscale identified in the first scaling of the IOC in a sample of 193 survivors of breast, colorectal, lymphatic and prostate cancers [28].

Reproducibility of factor structure

The 8-factor structure of the IOCv2 positive and negative subscales exhibited by the BC survivor sample was well-reproduced in the NHL survivor sample, as evidenced by high congruence coefficients (Table 3). All item congruences exceeded 0.90 with the exception of two items on the Life Interferences subscale. Despite these lower values, the factor congruence for Life Interferences was 0.88. Other factor congruences ranged from 0.95–0.98.

Table 3

Results of reproducibility analysis comparing factor structure for non-Hodgkin lymphoma and breast cancer survivor samples

IOCv2 subscales and items	Factor Congruence	Item Congruence
Altruism/Empathy	0.96
Having had cancer has made me more willing to help others		0.99
Because I had cancer I am more understanding of what others feel		0.96
I feel a special bond with people with cancer		0.98
I feel I should give something back to others		0.98
Health awareness	0.95
Having had cancer has made me more concerned about my health.		1.00
I do not take my body for granted since I had cancer.		0.94
I am more aware of physical problems or changes.		0.99
Having had cancer has made me take better care of myself.		0.96
Meaning of cancer	0.98
Because of cancer I have more confidence in myself		0.99
Having had cancer has given me direction in life		0.99
Because of cancer I have become better about expressing what I want		0.99
Because of having had cancer I feel that I have more control of my life		0.98
Having had cancer turned into a reason to make changes in my life		0.97
Positive self-evaluation	0.97
I feel a sense of pride or accomplishment from surviving cancer		0.99
I consider myself to be a cancer survivor		0.96
I learned something about myself because of having had cancer		0.98
I feel that I am a role model		0.97
Appearance concerns	0.96
I feel disfigured		0.99
I sometimes wear clothing to cover parts of my body		0.98
I worry about how my body looks		0.98
Body change concerns	0.97
I am bothered that my body cannot do what it could before		0.99
I am concerned that my energy has not returned		0.99
Having had cancer has made me feel old.		0.99
Life interferences	0.88
Uncertainty about my future affects my decisions to make plans		0.34
Having had cancer has made me feel alone.		0.98
Having had cancer keeps me from doing activities I enjoy		0.58
I feel like cancer runs my life.		0.99
Having had cancer has made me feel that some people do not understand me		0.95
I feel guilty today for not having been available to my family		0.90
Ongoing symptoms interfere with my life.		0.95
Worry	0.98
Having had cancer makes me feel uncertain about my health		0.98
I worry about the future		0.97
Having had cancer makes me feel unsure about the future		0.97
I worry about cancer coming back		0.95
New symptoms make me worry about cancer coming back		0.97
I worry about my health		0.97
I feel like time in my life in running out		0.93

Concurrent validity

Table 4 summarizes the NHL survivor scores on the FACT, SF-36, PCL-C, PTGI and Social Support scales, and presents the correlations of these scores with the IOCv2 positive scales. Table 5 presents correlations with the IOCv2 negative and employment and relationship concern scales.

Table 4

FACT, PCL-C, SF-36, PTGI, and Social Support scores in the NHL survivor sample and correlations (r) with IOCv2 scores on positive scales

Instrumenta	Mean±SD	Positive impact summary score	Positive subscales
			Altruism/ Empathy	Health awareness	Meaning of cancer	Positive self-evaluation
FACT-G (+)
Total	88 ± 15	0.08	0.04	−0.02	0.07	0.15
Physical	24 ± 5	−0.07	−0.09	−0.08	−0.06	0.01
Social/Family	23 ± 5	0.19	0.21	0.07	0.13	0.20
Emotional	20 ± 4	0.01	−0.03	−0.09	0.02	0.13
Functional	21 ± 6	0.13	0.07	0.02	0.14	0.17
LYM	137 ± 22	0.02	−0.01	−0.06	0.01	0.11
SF-36 (+)
Physical comp.	46 ± 10	−0.01	−0.06	−0.01	0.01	0.03
Mental comp.	50 ± 11	−0.00	−0.03	−0.06	0.01	0.08
SF-36 subscales
Physical funct.	45 ± 12	−0.02	−0.06	0.01	−0.03	0.01
Role-physical	45 ± 12	−0.01	−0.08	−0.03	0.02	0.03
Bodily pain	51 ± 10	−0.02	−0.07	−0.02	−0.00	0.02
General health	46 ± 11	0.02	−0.04	−0.05	0.05	0.08
Vitality	49 ± 12	0.06	−0.01	−0.01	0.08	0.09
Social function.	49 ± 11	0.00	−0.04	−0.04	0.02	0.06
Role-emotional	46 ± 13	−0.04	−0.07	−0.05	−0.04	0.04
Mental health	50 ± 10	−0.03	−0.05	−0.07	−0.02	0.05
PCL-C (−)
Total	26 ± 9	0.07	0.08	0.12	0.05	−0.03
Re-experiencing	7 ± 3	0.14	0.11	0.17	0.12	0.04
Avoidance	10 ± 4	−0.01	0.01	0.09	−0.02	−0.11
Arousal	9 ± 4	0.09	0.11	0.08	0.06	0.03
PTGI (+)
Total	62 ± 24	0.75***	0.64***	0.45**	0.69***	0.56**
Rel’ship w/others	23 ± 9	0.67***	0.62***	0.38*	0.58**	0.53**
New possibilities	11 ± 7	0.71***	0.56**	0.41*	0.70***	0.50**
Pers’l strength	12 ± 5	0.67***	0.55**	0.38*	0.65***	0.51**
Spiritual change	6 ± 3	0.60***	0.55**	0.34*	0.53**	0.49**
Apprec. of life	10 ± 4	0.68***	0.56**	0.51**	0.59**	0.47**
Social support (+)
Total	84 ± 16	0.10	0.09	0.02	0.07	0.14
Emotional/Info	81 ± 18	0.09	0.07	0.01	0.07	0.12
Tangible	84 ± 19	0.08	0.08	0.02	0.04	0.13
Affectionate	90 ± 17	0.09	0.10	0.02	0.05	0.10
Pos. interaction	86 ± 19	0.09	0.08	0.03	0.07	0.11

FACT Functional Assessment of Cancer Therapy; PCL-C Post-traumatic Stress Disorder Checklist-Civilian Version; PTGI Post-Traumatic Growth Inventory.

*0.30 ≤ |r| < 0.45; **0.45 ≤ |r| < 0.60; ***|r| ≥ 0.60; and P < 0.005 for test that correlation equals zero.

a Instruments completed concurrently with the IOC. Direction of scoring is indicated in parentheses, with a negative (−) sign indicating that higher scores correspond to poorer functioning and a positive (+) sign indicating that higher scores correspond to better functioning.

Table 5

Correlations (r) of FACT, PCL-C, SF-36, PTGI, and Social Support scores in the NHL survivor sample with IOCv2 scores on negative scales

Instrumenta	Negative impact summary score	Negative subscales				Employ conc	Rel’ship conc: not partnered	Rel’ship conc: partnered
		Appear conc	Body chg conc	Life interfer	Worry
FACT-G (+)
Total	−0.68***	−0.45**	−0.60***	−0.59**	−0.52**	−0.45**	−0.64***	−0.45**
Physical	−0.59**	−0.38*	−0.65***	−0.52**	−0.38*	−0.36*	−0.55**	−0.28
Social/Family	−0.39*	−0.30*	−0.27	−0.31*	−0.34*	−0.33*	−0.42*	−0.49**
Emotional	−0.70***	−0.40*	−0.50**	−0.59**	−0.63***	−0.38*	−0.62***	−0.36*
Functional	−0.53**	−0.37*	−0.51**	−0.47**	−0.38*	−0.37*	−0.45**	−0.32*
LYM	−0.73***	−0.47**	−0.64***	−0.63***	−0.56**	−0.48**	−0.62***	−0.43*
SF-36 (+)
Physical comp.	−0.30*	−0.19	−0.41*	−0.29	−0.15	−0.13	−0.04	−0.13
Mental comp.	−0.53**	−0.34*	−0.47**	−0.47**	−0.41*	−0.34*	−0.54**	−0.31*
SF-36 Subscales
Physical funct.	−0.26	−0.15	−0.38*	−0.28	−0.10	−0.12	−0.00	−0.13
Role-physical	−0.35*	−0.22	−0.46**	−0.35*	−0.17	−0.16	−0.19	−0.15
Bodily pain	−0.35*	−0.22	−0.37*	−0.33*	−0.22	−0.17	−0.19	−0.18
General health	−0.52**	−0.32*	−0.50**	−0.44*	−0.41*	−0.31*	−0.32*	−0.23
Vitality	−0.50**	−0.33*	−0.55**	−0.40*	−0.36*	−0.28	−0.37*	−0.27
Social function.	−0.44*	−0.30*	−0.42*	−0.45**	−0.28	−0.27	−0.34*	−0.29
Role-emotional	−0.41*	−0.25	−0.45**	−0.41*	−0.25	−0.24	−0.36*	−0.22
Mental health	−0.53**	−0.32*	−0.44*	−0.46**	−0.44*	−0.36*	−0.49**	−0.32*
PCL-C (−)
Total	0.70***	0.41*	0.56**	0.63***	0.57**	0.43*	0.59**	0.39*
Re-experiencing	0.54**	0.29	0.40*	0.51**	0.47**	0.37*	0.53**	0.22
Avoidance	0.66***	0.39*	0.52**	0.61***	0.54**	0.36*	0.63***	0.42*
Arousal	0.59**	0.37*	0.51**	0.52**	0.47**	0.37*	0.39*	0.33*
PTGI (+)
Total	0.09	0.07	0.11	0.15	0.00	0.05	0.03	−0.10
Rel’ship w/others	0.07	0.04	0.12	0.13	−0.01	0.01	−0.03	−0.13
New possibilities	0.06	0.09	0.06	0.13	−0.02	0.09	0.08	−0.05
Pers’l strength	0.06	0.05	0.08	0.12	−0.02	0.04	−0.00	−0.08
Spiritual change	0.10	0.08	0.12	0.17	−0.01	0.06	0.04	−0.05
Apprec. of life	0.17	0.08	0.14	0.19	0.12	0.10	0.16	−0.11
Social Support (+)
Total	−0.29	−0.25	−0.18	−0.26	−0.24	−0.29	−0.43*	−0.41*
Emotional/Info	−0.28	−0.18	−0.18	−0.27	−0.23	−0.26	−0.42*	−0.34*
Tangible	−0.20	−0.19	−0.11	−0.18	−0.17	−0.20	−0.31*	−0.30*
Affectionate	−0.20	−0.23	−0.10	−0.15	−0.17	−0.25	−0.28	−0.41*
Pos. interaction	−0.26	−0.29	−.18	−0.22	−0.19	−0.28	−0.38*	−0.41*

conc concerns; FACT Functional Assessment of Cancer Therapy; PCL-C Post-traumatic Stress Disorder Checklist-Civilian Version; PTGI Post-Traumatic Growth Inventory.

*0.30 ≤ |r| < 0.45; **0.45 ≤ |r| < 0.60; *** |r| ≥ 0.60; and P < 0.005 for test that correlation equals zero.

aInstruments completed concurrently with the IOC. Direction of scoring is indicated in parentheses, with a negative (−) sign indicating that higher scores correspond to poorer functioning and a positive (+) sign indicating that higher scores correspond to better functioning.

The observed patterns of association were largely consistent with prior hypotheses. There was a striking lack of correlation between the IOCv2 positive scales and the FACT-G, FACT-LYM and SF-36, supporting the distinctive content of the IOCv2 positive domains from these scales. The PCL-C and Social Support scales were also uncorrelated with the IOCv2 positive scales, indicating that the IOCv2 positive constructs were unrelated to either post-traumatic stress symptoms or perceived availability of particular relationships. Strong or substantial correlations were observed between the PTGI and IOCv2 Altruism/Empathy, Meaning of Cancer and Positive Self-Evaluation, as well as the IOCv2 Positive Impact Summary, as expected due to their similar goal of measuring personal growth ascribed to a traumatic experience. There was lesser correlation with IOCv2 Health Awareness, consistent with the lack of health focus of the PTGI.

As expected, there was an overall pattern of moderate to strong correlation between the IOCv2 negative scales and the FACT-G, FACT-LYM and SF-36, with higher correlations evident for the FACT-G and FACT-LYM, which are cancer-specific, than for the SF-36, which is not. The strongest correlation was between the IOCv2 Negative Impact Summary score and the FACT-LYM, which is specifically designed to measure negative HRQOL symptoms in lymphoma survivors. The IOCv2 Negative Impact Summary score was also correlated with the other aggregate measures of negative impacts (FACT-G, SF-36 Physical and Mental, PCL-C). Particularly striking were strong correlations between the IOCv2 negative scales and the PCL-C. These correlations are consistent with the parallel approaches of the PCL-C and IOCv2, which both focus on concerns that respondents attribute specifically to their cancer experience. The IOCv2 negative scales were uncorrelated with the PTGI, and weakly inversely correlated with Social Support.

With regard to the negative subscales, IOCv2 Appearance Concerns showed diffuse connection with various physical and emotional scales. IOCv2 Body Change Concerns was correlated with scales measuring physical concerns, and also correlated with mental and emotional scales; this is consistent with the item content of Body Change Concerns, which focuses on emotional reactions to physical changes. IOCv2 Life Interferences showed correlation with each of the FACT-G subscales and SF-36 Mental, and was most strongly correlated with FACT-LYM and PCL-C Total. IOCv2 Worry was most strongly correlated with FACT-G Emotional, which contains items pertaining to worry. IOCv2 Employment Concerns showed correlation with the FACT-G, SF-36 and PCL-C, suggesting more employment concerns among respondents with poorer overall HRQOL. The IOCv2 Relationship Concerns subscales were inversely correlated with the Social Support scales, and also correlated with the FACT-G, FACT-LYM, SF-36 Mental and PCL-C scales, suggesting more relationship concerns among respondents with poorer HRQOL.

Comparison of IOCv2 scores

Table 6 provides Cronbach’s alpha for the IOCv2 scales for both survivor groups. All alphas for the BC group exceeded 0.75. All alphas for the NHL group exceeded 0.70 with the exception of Relationship Concerns (non-partnered), which had alpha = 0.59. Many authorities consider alpha > 0.70 acceptable [48], while others accept alpha > 0.50 or 0.60 [49].

Table 6

Cronbach’s alpha statistics and unadjusted and adjusted mean IOCv2 scale scores for non-Hodgkin lymphoma and breast cancer survivor samples

Scale	Cronbach’s alpha		Unadjusted means±SD (range)			Adjusted means
	BC	NHL	BC	NHL	P, NHL v BC	BC	NHL, women only	NHL, men and women	P, BC v NHL women only	P, BC v NHL men and women
Higher-order scales
Pos summary	0.79	0.90	3.6 ± 0.6 (1.2–5)	3.5 ± 0.8 (1–5)	0.04	3.6	3.7	3.5	0.22	0.09
Neg summary	0.81	0.91	2.4 ± 0.7 (1–4.8)	2.1 ± 0.7 (1–4.7)	<0.001	2.4	2.2	2.2	0.007	<0.001
Pos. subscales
Altru/Empathy	0.82	0.87	3.8 ± 0.7 (1–5)	3.9 ± 0.9 (1–5)	<0.001	3.7	4.1	3.9	<0.001	0.004
Health aware	0.80	0.71	3.8 ± 0.7 (1–5)	3.7 ± 0.8 (1–5)	0.01	3.8	3.8	3.7	0.94	0.26
Meaning of Ca	0.87	0.87	3.0 ± 0.8 (1-5)	2.8 ± 1.1 (1–5)	<0.001	3.0	2.9	2.8	0.08	<0.001
Pos self-eval	0.79	0.77	4.0 ± 0.7 (1–5)	4.0 ± 0.9 (1–5)	0.86	4.0	4.1	3.9	0.14	0.20
Neg. subscales
Appear. conc	0.78	0.76	2.7 ± 1.0 (1–5)	1.6 ± 0.8 (1–5)	<0.001	2.7	1.8	1.7	<0.001	<0.001
Body chg conc	0.82	0.83	2.6 ± 1.0 (1–5)	2.3 ± 1.2 (1–5)	<0.001	2.5	2.5	2.5	0.66	0.54
Life interfer	0.81	0.71	1.9 ± 0.6 (1–4.4)	1.9 ± 0.7 (1–4.6)	0.90	1.9	1.9	2.0	0.46	0.17
Worry	0.89	0.89	2.8 ± 0.8 (1–5)	2.5 ± 1.0 (1–5)	<0.001	2.7	2.6	2.6	0.17	0.09
Other subscales
Employ conc	0.76	0.75	2.7 ± 1.1 (1–5)	2.4 ± 1.2 (1–5)	0.002	2.7	2.4	2.5	0.12	0.27
Rel’ship conc (not partnered)	0.78	0.59	2.1 ± 0.9 (1–5)	1.6 ± 0.9 (1–5)	<0.001	2.0	1.5	1.7	0.004	0.03
Rel’ship conc (partnered)	0.80	0.77	1.7 ± 0.6 (1–4.5)	1.4 ± 0.6 (1–3.5)	<0.001	1.6	1.5	1.4	0.003	<0.001

BC breast cancer; NHL non-Hodgkin lymphoma.

For all scales, potential scores range from 1 to 5, with higher scores indicating stronger endorsement of the content area and with a score of 3 as neutral. Adjusted means are adjusted for age and years since diagnosis.

For both groups, scores on all IOCv2 scales ranged over all or most of the possible 1 to 5 range, suggesting good potential for sensitivity and discrimination.

Table 6 compares unadjusted and adjusted mean IOCv2 scores for the BC and NHL survivors, with the adjustment accounting for differences in age and years since diagnosis. To account for gender differences, adjusted means for the BC sample and women in the NHL sample are also compared.

Unadjusted and adjusted mean scores for both groups on the Positive Impact Summary Scale were in the “agree” range, indicating endorsement of positive impacts due to cancer in both groups. A marginally significant difference in unadjusted mean scores between the BC and NHL survivors became non-significant after adjusting for age and time since diagnosis. However, there were differences between the groups on positive subscales that remained after adjustment. In particular, the NHL survivors had higher mean scores on Altruism/Empathy and lower scores on Meaning of Cancer. Differences on the latter were partially accounted for by gender differences, with NHL men scoring lower on Meaning of Cancer than NHL women on average.

Mean scores on the Negative Impact Summary Scale were in the “disagree” range and differed between the groups in adjusted and unadjusted analyses, with the BC survivors reporting more negative impacts. Mean scores on Appearance Concerns were a full point higher among the BC survivors. Differences on Body Change Concerns, Life Interferences and Worry were non-significant after adjustment.

The BC survivors reported higher levels of relationship concerns, both for partnered and unpartnered respondents, with these differences remaining significant after adjustment.

Discussion

There is a need for well-validated measures of the cancer-specific HRQOL of long-term cancer survivors that can be used across the spectrum of cancer diagnoses. Our study was undertaken to examine the generalizability of the IOCv2 across two distinct survivor groups. We compared the measurement of the impact of cancer in large samples of BC survivors and NHL survivors and found evidence for similar impact domains across the two groups, providing confidence that the IOCv2 scales measure common and important survivor concerns.

Compared to the BC group, the NHL survivors represented a broader range of time since diagnosis and ages at diagnosis, as well as both genders, and came from a different geographic area of the US. The good psychometric properties of the scales in this distinct group, as well as the participation of diverse samples of survivors in earlier stages of IOC development, support the appropriateness of the IOCv2 as a tool to measure the psychosocial impacts of cancer in the broader long-term survivor population. However, some limitations in generalizability remain. While our NHL survivor sample included 151 participants who were survivors within 2–5 years of diagnosis, more work is needed to confirm that the IOCv2 items and factor structure capture domains that are relevant to early survivors, who are closer to the transition from patient to survivor and thus may be experiencing different psychosocial needs [7].

Some differences emerged in the independent scalings in the BC and NHL samples. Content of the Life Interferences domain differed somewhat across samples, and merged with Body Change Concerns in NHL survivors. Consistent with this is the high correlation between these two subscales in the BC sample (r = 0.6) [30]. Overall these findings suggest overlap between these two domains. While the content of the Life Interferences subscale was not fully congruent between the BC and NHL survivors, the importance of a life interferences domain for NHL survivors is supported by the study of Bellizzi et al. [16], who report substantial proportions of NHL survivors endorsing negative impacts on ability to participate in social and exercise activities and to enjoy life as well as on financial, career and insurance situations.

The Positive Outlook subscale, which emerged in early IOC scaling with 193 survivors of breast, colorectal, lymphatic and prostate cancers, also emerged in the NHL sample but was not evident in the large BC sample. The sample used for early IOC scaling included 49 (25%) lymphoma (Hodgkin and NHL) survivors, suggesting that this domain might reflect concerns of this group that are not as prevalent in BC survivors. Alternatively, the difference may be due to the restriction of the BC sample to long-term survivors who were within 10 years of their diagnosis; one of the theoretical foundations of growth is sufficient time to think about and integrate experiences into one’s life [50], and the time interval may have been insufficient for some of the BC survivors. Future research may explore the universality of this construct and its association with time since diagnosis.

We have also compared IOCv2 scores in NHL and BC survivors. Normative and comparative scores across groups will be important in facilitating interpretation and identifying at-risk populations to target for intervention. Differences between the NHL and BC groups for several domains, including the Negative Impact Summary scale and Altruism/Empathy, Meaning of Cancer, Appearance Concerns and Relationship Concerns subscales, suggest that the IOCv2 scales are able to distinguish differential impacts in different survivor groups. While it is beyond the scope of this paper to fully explore the antecedents of these differences, we can offer several observations. Subscale comparisons suggest that the difference in Negative Impact Summary scores between the BC and NHL groups may be largely attributable to differences on the Appearance Concerns subscale, with BC survivors scoring about a full point higher on this domain. Body image is a widely reported concern among BC survivors (e.g. [51, 52]). However, this should not be taken as evidence that appearance concerns are exclusive to BC survivors, as such concerns are also reported among survivors with other diagnoses (e.g. [53-56]). Among perceived positive impacts of cancer, the NHL survivors scored higher on Altruism/Empathy while the BC survivors scored higher on Meaning of Cancer. This may be interpreted as a difference in benefit-finding domains in these two groups. There is a sizable literature examining predictors of posttraumatic growth in cancer survivors; within this literature, disease and treatment characteristics have shown inconsistent associations with posttraumatic growth [57]. To the extent that the IOCv2 identifies four distinct positive impact domains which may be differentially associated with disease and treatment characteristics, it may assist in providing greater differentiation and clarity in this area in future research. We plan future work to further characterize the perceived impact of cancer in NHL survivors using the IOCv2 scales.

The higher order positive and negative summary scores of the IOCv2 provide aggregate measures of impacts that may be especially useful when data reduction is important. However, as we saw with the positive scale scores in BC and NHL survivors, groups can differ on subscales while having little or no difference in summary scores. Hence we would recommend that researchers using the IOCv2 examine both summary and subscale scores. Indeed, the capability of eliciting different patterns of scores across different survivor groups is an advantage of a multidimensional measure such as the IOCv2.

Our study has several limitations. Respondents tended to be older and were less racially/ethnically diverse than nonrespondents in both groups, creating the potential for response biases. Since our surveys were cross-sectional, we were not able to evaluate test-retest reliability nor the ability of the IOCv2 to measure change over time, which will be important to assess in future research. In addition, the 47 items for the IOCv2 were selected based on data collected via full administration of the 81-item IOC questionnaire. It will be important to examine whether the domain and factor structure of the IOCv2 holds up when the 47-item only instrument is utilized in future studies. Work is also needed to evaluate the IOCv2 in clinical settings, where it could be used as a screening tool or to measure outcomes in a clinical trial or program evaluation.

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