Literature DB >> 19946590

Chemical pneumonitis and subsequent reactive airways dysfunction syndrome after a single exposure to a household product: a case report.

Imran Khalid1, Amanda M Godfrey, Daniel R Ouellette.   

Abstract

INTRODUCTION: Household products are usually safe to use. Adverse events arising from their use are mostly reported in patients with pre-existing atopy or pulmonary problems and usually only after a prolonged exposure to such products. We report the case of a patient with no prior problems who developed significant side effects from a single exposure to a domestic product. CASE
PRESENTATION: A 43-year-old Caucasian American man, previously in good health, used a domestic aerosol product called 'Stand N' Seal "Spray-On" Grout Sealer' in an enclosed room in his house. The product contained n-butyl acetate (<5%), propane (10%), isobutane (<5%), C8-C9 petroleum hydrocarbon solvent (80%), a fluoropolymer resin and a solvent. Within a few hours of exposure to the sealant, he developed rapidly progressive shortness of breath and a severe non-productive cough. By the time he reached the emergency room he was severely hypoxic. A diagnosis of chemical pneumonitis was made based on the clinical scenario and the diffuse infiltrates on the computer tomography scan. With supportive therapy, his condition improved and he was discharged from the hospital. However, he continued to have symptoms of intermittent cough and shortness of breath in response to strong odours, fumes, cold air and exertion even after his chest radiograph had normalized. Three months later, bronchial hyper-responsiveness was documented by a methacholine inhalation test and a diagnosis of reactive airways dysfunction syndrome was made. The patient was started on high-dose inhaled steroids and his symptoms improved. The mechanism of toxicity and determination of the exact agent responsible is still under investigation.
CONCLUSION: A household product may still prove unsafe to use even after it has gone through vigorous testing and approval processes. Even healthy individuals are susceptible to adverse outcomes after a brief exposure. Extra precautions should be taken when using any chemical product at home.

Entities:  

Year:  2009        PMID: 19946590      PMCID: PMC2783053          DOI: 10.1186/1752-1947-3-112

Source DB:  PubMed          Journal:  J Med Case Rep        ISSN: 1752-1947


  15 in total

1.  Persistent hyperreactivity and reactive airway dysfunction in firefighters at the World Trade Center.

Authors:  Gisela I Banauch; Dawn Alleyne; Raoul Sanchez; Kattia Olender; Hillel W Cohen; Michael Weiden; Kerry J Kelly; David J Prezant
Journal:  Am J Respir Crit Care Med       Date:  2003-02-25       Impact factor: 21.405

2.  Severe asthma and ARDS triggered by acute short-term exposure to commonly used cleaning detergents.

Authors:  C E Mapp; V Pozzato; V Pavoni; G Gritti
Journal:  Eur Respir J       Date:  2000-09       Impact factor: 16.671

3.  Acute pulmonary toxicity following occupational exposure to a floor stain protector in the building industry in Switzerland.

Authors:  Catherine Lazor-Blanchet; Sophie Rusca; David Vernez; Raymond Berry; Eric Albrecht; Pierre-Olivier Droz; Marcel-André Boillat
Journal:  Int Arch Occup Environ Health       Date:  2004-03-06       Impact factor: 3.015

Review 4.  Diagnosis and management of work-related asthma: American College Of Chest Physicians Consensus Statement.

Authors:  Susan M Tarlo; John Balmes; Ronald Balkissoon; Jeremy Beach; William Beckett; David Bernstein; Paul D Blanc; Stuart M Brooks; Clayton T Cowl; Feroza Daroowalla; Philip Harber; Catherine Lemiere; Gary M Liss; Karin A Pacheco; Carrie A Redlich; Brian Rowe; Julia Heitzer
Journal:  Chest       Date:  2008-09       Impact factor: 9.410

5.  Reactive airways dysfunction syndrome due to chlorine: sequential bronchial biopsies and functional assessment.

Authors:  C Lemière; J L Malo; M Boutet
Journal:  Eur Respir J       Date:  1997-01       Impact factor: 16.671

6.  Sudden death due to butane inhalation.

Authors:  T P Rohrig
Journal:  Am J Forensic Med Pathol       Date:  1997-09       Impact factor: 0.921

7.  Asthma, chronic bronchitis, and exposure to irritant agents in occupational domestic cleaning: a nested case-control study.

Authors:  M Medina-Ramón; J P Zock; M Kogevinas; J Sunyer; Y Torralba; A Borrell; F Burgos; J M Antó
Journal:  Occup Environ Med       Date:  2005-09       Impact factor: 4.402

8.  Reactive airways dysfunction syndrome in housewives due to a bleach-hydrochloric acid mixture.

Authors:  Metin Gorguner; Sahin Aslan; Tacettin Inandi; Zeynep Cakir
Journal:  Inhal Toxicol       Date:  2004-02       Impact factor: 2.724

9.  Reactive airways dysfunction syndrome (RADS). Persistent asthma syndrome after high level irritant exposures.

Authors:  S M Brooks; M A Weiss; I L Bernstein
Journal:  Chest       Date:  1985-09       Impact factor: 9.410

Review 10.  Which agents cause reactive airways dysfunction syndrome (RADS)? A systematic review.

Authors:  M S Shakeri; F D Dick; J G Ayres
Journal:  Occup Med (Lond)       Date:  2008-02-27       Impact factor: 1.611

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  4 in total

1.  Inhalational exposure to dimethyl sulfate vapor followed by reactive airway dysfunction syndrome.

Authors:  Abbas Aghabiklooei; Nasim Zamani; Hamidreza Shiva; Nader Rezaei
Journal:  Indian J Occup Environ Med       Date:  2010-09

2.  Mechanism of action of lung damage caused by a nanofilm spray product.

Authors:  Søren T Larsen; Constantin Dallot; Susan W Larsen; Fabrice Rose; Steen S Poulsen; Asger W Nørgaard; Jitka S Hansen; Jorid B Sørli; Gunnar D Nielsen; Camilla Foged
Journal:  Toxicol Sci       Date:  2014-05-25       Impact factor: 4.849

3.  Pulmonary toxicity following exposure to a tile coating product containing alkylsiloxanes. A clinical and toxicological evaluation.

Authors:  P Duch; A W Nørgaard; J S Hansen; J B Sørli; P Jacobsen; F Lynggard; M Levin; G D Nielsen; P Wolkoff; N E Ebbehøj; S T Larsen
Journal:  Clin Toxicol (Phila)       Date:  2014-05-12       Impact factor: 4.467

4.  An adverse outcome pathway for lung surfactant function inhibition leading to decreased lung function.

Authors:  Emilie Da Silva; Ulla Vogel; Karin S Hougaard; Jesus Pérez-Gil; Yi Y Zuo; Jorid B Sørli
Journal:  Curr Res Toxicol       Date:  2021-05-27
  4 in total

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