Literature DB >> 19944180

Status of APOBEC3G/F in cells and progeny virions modulated by Vif determines HIV-1 infectivity.

Tomoki Yamashita1, Masako Nomaguchi, Ariko Miyake, Tsuneo Uchiyama, Akio Adachi.   

Abstract

We examined various HIV-1 Vif mutants for interaction with APOBEC3 proteins (A3G/A3F). All replication-defective proviral mutants were found to carry A3G/A3F in virions, and of these, a replication-defective mutant with Vif that binds to A3G in cells but not in virions was noted. Furthermore, a mutant Vif protein that suppresses A3F activity but does not exclude A3F from virions was identified. We also showed that incorporation of Vif into virions is dependent on its interaction with A3G/A3F. Taken together, we concluded that functional binding of Vif to A3G/A3F in cells and/or virions is critical for viral infectivity. Copyright 2009 Elsevier Masson SAS. All rights reserved.

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Year:  2009        PMID： 19944180     DOI： 10.1016/j.micinf.2009.11.007

Source DB:  PubMed          Journal:  Microbes Infect        ISSN： 1286-4579            Impact factor:   2.700


  9 in total

Review 1.  HIV-1 Vif versus the APOBEC3 cytidine deaminases: an intracellular duel between pathogen and host restriction factors.

Authors:  Silke Wissing; Nicole L K Galloway; Warner C Greene
Journal:  Mol Aspects Med       Date:  2010-06-09

2.  Catalytic activity of APOBEC3F is required for efficient restriction of Vif-deficient human immunodeficiency virus.

Authors:  John S Albin; William L Brown; Reuben S Harris
Journal:  Virology       Date:  2013-12-20       Impact factor: 3.616

Review 3.  Protein intrinsic disorder as a flexible armor and a weapon of HIV-1.

Authors:  Bin Xue; Marcin J Mizianty; Lukasz Kurgan; Vladimir N Uversky
Journal:  Cell Mol Life Sci       Date:  2011-10-28       Impact factor: 9.261

4.  Multifaceted counter-APOBEC3G mechanisms employed by HIV-1 Vif.

Authors:  Elena Britan-Rosich; Roni Nowarski; Moshe Kotler
Journal:  J Mol Biol       Date:  2011-07-29       Impact factor: 5.469

5.  Mapping the Vif-A3G interaction using peptide arrays: a basis for anti-HIV lead peptides.

Authors:  Tali H Reingewertz; Elena Britan-Rosich; Shahar Rotem-Bamberger; Mathias Viard; Amy Jacobs; Abigail Miller; Ji Youn Lee; Jeeseong Hwang; Robert Blumenthal; Moshe Kotler; Assaf Friedler
Journal:  Bioorg Med Chem       Date:  2013-03-14       Impact factor: 3.641

6.  HIV-1 VIF and human APOBEC3G interaction directly observed through molecular specific labeling using a new dual promotor vector.

Authors:  Wazo Myint; Celia A Schiffer; Hiroshi Matsuo
Journal:  J Magn Reson       Date:  2022-04-26       Impact factor: 2.734

7.  Identifying potential survival strategies of HIV-1 through virus-host protein interaction networks.

Authors:  David van Dijk; Gokhan Ertaylan; Charles Ab Boucher; Peter Ma Sloot
Journal:  BMC Syst Biol       Date:  2010-07-15

8.  Expression Level of HIV-1 Vif Can Be Fluctuated by Natural Nucleotide Variations in the vif-Coding and Regulatory SA1D2prox Sequences of the Proviral Genome.

Authors:  Naoya Doi; Takaaki Koma; Akio Adachi; Masako Nomaguchi
Journal:  Front Microbiol       Date:  2019-11-28       Impact factor: 5.640

9.  The Expression Level of HIV-1 Vif Is Optimized by Nucleotide Changes in the Genomic SA1D2prox Region during the Viral Adaptation Process.

Authors:  Takaaki Koma; Naoya Doi; Mai Takemoto; Kyosuke Watanabe; Hideki Yamamoto; Satoshi Nakashima; Akio Adachi; Masako Nomaguchi
Journal:  Viruses       Date:  2021-10-15       Impact factor: 5.048
  9 in total

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