OBJECTIVES: To evaluate oxidative stress and the extent of oxidation of plasma proteins in type 2 diabetic patients. DESIGN AND METHODS: Study was carried out on blood from 31 diabetic patients of both sexes (mean age = 58 + or - 7; duration of diabetes 12 + or - 5 years) and healthy age and sex matched normal subjects. Biomarkers of protein oxidation; plasma protein carbonyls (PCO), advanced oxidation protein products (AOPPs) and -SH group and free radical scavenging capacity of plasma was measured. RESULTS: PCO and AOPPS levels were significantly (P<0.005) higher in diabetic patients in comparison to healthy volunteers. Reduced free radical scavenging capacity (P<0.001) and -SH group (P<0.05) was observed in plasma of type 2 diabetic patients. CONCLUSIONS: Our data suggest that diabetics are susceptible to protein oxidation. Oxidative modulation of proteins due to reduced radical scavenging activity of plasma patients may be one of the reasons of altered physiological processes in type 2 diabetic patients. Copyright 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
OBJECTIVES: To evaluate oxidative stress and the extent of oxidation of plasma proteins in type 2 diabeticpatients. DESIGN AND METHODS: Study was carried out on blood from 31 diabeticpatients of both sexes (mean age = 58 + or - 7; duration of diabetes 12 + or - 5 years) and healthy age and sex matched normal subjects. Biomarkers of protein oxidation; plasma protein carbonyls (PCO), advanced oxidation protein products (AOPPs) and -SH group and free radical scavenging capacity of plasma was measured. RESULTS: PCO and AOPPS levels were significantly (P<0.005) higher in diabeticpatients in comparison to healthy volunteers. Reduced free radical scavenging capacity (P<0.001) and -SH group (P<0.05) was observed in plasma of type 2 diabeticpatients. CONCLUSIONS: Our data suggest that diabetics are susceptible to protein oxidation. Oxidative modulation of proteins due to reduced radical scavenging activity of plasma patients may be one of the reasons of altered physiological processes in type 2 diabeticpatients. Copyright 2009 The Canadian Society of Clinical Chemists. Published by Elsevier Inc. All rights reserved.
Authors: Renata da Silva Pereira; Etiane Tatsch; Guilherme Vargas Bochi; Helena Kober; Thiago Duarte; Greice Franciele Feyh dos Santos Montagner; José Edson Paz da Silva; Marta Maria Medeiros Frescura Duarte; Ivana Beatrice Mânica da Cruz; Rafael Noal Moresco Journal: Inflammation Date: 2013-08 Impact factor: 4.092
Authors: Alliny de Souza Bastos; Dana T Graves; Ana Paula de Melo Loureiro; Carlos Rossa Júnior; Sâmia Cruz Tfaile Corbi; Fausto Frizzera; Raquel Mantuaneli Scarel-Caminaga; Niels Olsen Câmara; Oelisoa M Andriankaja; Meire I Hiyane; Silvana Regina Perez Orrico Journal: J Diabetes Complications Date: 2016-07-21 Impact factor: 2.852
Authors: Hongmei Li-Byarlay; Ming Hua Huang; Michael Simone-Finstrom; Micheline K Strand; David R Tarpy; Olav Rueppell Journal: Exp Gerontol Date: 2016-07-12 Impact factor: 4.032