| Literature DB >> 19924861 |
Yuxiang Dong1, Sergio Wittlin, Kamaraj Sriraghavan, Jacques Chollet, Susan A Charman, William N Charman, Christian Scheurer, Heinrich Urwyler, Josefina Santo Tomas, Christopher Snyder, Darren J Creek, Julia Morizzi, Maria Koltun, Hugues Matile, Xiaofang Wang, Maniyan Padmanilayam, Yuanqing Tang, Arnulf Dorn, Reto Brun, Jonathan L Vennerstrom.
Abstract
The structure and stereochemistry of the cyclohexane substituents of analogues of arterolane (OZ277) had little effect on potency against Plasmodium falciparum in vitro. Weak base functional groups were not required for high antimalarial potency, but they were essential for high antimalarial efficacy in P. berghei-infected mice. Five new ozonides with antimalarial efficacy and ADME profiles superior or equal to that of arterolane were identified.Entities:
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Year: 2010 PMID： 19924861 DOI： 10.1021/jm901473s
Source DB: PubMed Journal: J Med Chem ISSN： 0022-2623 Impact factor: 7.446