| Literature DB >> 19912166 |
Shengde Wu1, Jing Zhu, Yasha Li, Tao Lin, Liqiang Gan, Xingang Yuan, Jing Xiong, Xing Liu, Mingdeng Xu, Dan Zhao, Chao Ma, Xuliang Li, Guanghui Wei.
Abstract
The aim of this study was to analyse epigenetic (specifically, DNA methylation) change in testes induced by maternal exposure to di-2-(ethylhexyl) phthalate (DEHP) in mice. Testicular dysgenesis syndrome was induced in foetuses by maternal exposure to DEHP. High-performance liquid chromatography was performed to analyse DNA methylation status, and expression levels of the DNA methyltransferases were examined by quantitative real-time polymerase chain reaction and western blotting. DEHP significantly had more than 10% relative increase in the global DNA methylation and also increased DNA methyltransferases' expression. Changes in DNA methylation may play an important role in abnormal testicular function caused by environmental factors such as maternal exposure to DEHP, which may be one possible mechanism of DEHP-mediated testicular toxicity.Entities:
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Year: 2009 PMID： 19912166 DOI： 10.1111/j.1742-7843.2009.00483.x
Source DB: PubMed Journal: Basic Clin Pharmacol Toxicol ISSN： 1742-7835 Impact factor: 4.080