| Literature DB >> 19904979 |
Tal Dvir1, Matthew R Banghart, Brian P Timko, Robert Langer, Daniel S Kohane.
Abstract
We report a novel and simple proof-of-concept of a nanoparticulate system that targets any tissue selectively upon illumination. Nanoparticles were covalently functionalized with the amino acid sequence YIGSR, which adheres to the beta1 integrins present on most cell surfaces. This peptide was masked with a caging group, rendering it biologically inert. Illumination with UV light released the caging group from the YIGSR, allowing binding to cells.Entities:
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Year: 2010 PMID: 19904979 PMCID: PMC2806491 DOI: 10.1021/nl903411s
Source DB: PubMed Journal: Nano Lett ISSN: 1530-6984 Impact factor: 11.189