| Literature DB >> 20858520 |
Prakash Rai1, Srivalleesha Mallidi, Xiang Zheng, Ramtin Rahmanzadeh, Youssef Mir, Stefan Elrington, Ahmat Khurshid, Tayyaba Hasan.
Abstract
Theranostics, the fusion of therapy and diagnostics for optimizing efficacy and safety of therapeutic regimes, is a growing field that is paving the way towards the goal of personalized medicine for the benefit of patients. The use of light as a remote-activation mechanism for drug delivery has received increased attention due to its advantages in highly specific spatial and temporal control of compound release. Photo-triggered theranostic constructs could facilitate an entirely new category of clinical solutions which permit early recognition of the disease by enhancing contrast in various imaging modalities followed by the tailored guidance of therapy. Finally, such theranostic agents could aid imaging modalities in monitoring response to therapy. This article reviews recent developments in the use of light-triggered theranostic agents for simultaneous imaging and photoactivation of therapeutic agents. Specifically, we discuss recent developments in the use of theranostic agents for photodynamic-, photothermal- or photo-triggered chemotherapy for several diseases. Published by Elsevier B.V.Entities:
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Year: 2010 PMID： 20858520 PMCID： PMC2991599 DOI： 10.1016/j.addr.2010.09.002
Source DB: PubMed Journal: Adv Drug Deliv Rev ISSN： 0169-409X Impact factor: 15.470