PURPOSE: The aim of this study was to clarify the relationship between the maximum standardized uptake value (maxSUV) and the expression levels of cell-cycle-related molecular biomarkers. PATIENTS AND METHODS: Thirty consecutive patients with non-small cell lung cancer (NSCLC) were enrolled in the study. Histologically, the tumors included 23 adenocarcinomas and 7 squamous cell carcinomas. Protein expressions of Ki-67, proliferating cell nuclear antigen (PCNA), and p53 were examined by immunohistochemistry. RESULTS: The maxSUV was higher in poorly differentiated NSCLCs than in well-differentiated and moderately differentiated tumors (p <0.05). The Ki-67 labeling index was higher in squamous cell carcinomas than in adenocarcinomas (p <0.05), and also in poorly differentiated tumors than in well-differentiated and moderately differentiated tumors (p <0.01). A positive correlation was found between the maxSUV and Ki-67 expression level (r = 0.687, p <0.001). No correlation was found between maxSUV and PCNA expression (r = 0.214, p = 0.248) or between maxSUV and p53 expression (r = 0.357, p = 0.09). Among the molecular biomarkers, an association was found between the expression levels of Ki-67 and PCNA (r = 0.515, p <0.01). CONCLUSIONS: Immunohistochemical staining with Ki-67 in NSCLC correlates with maxSUV. Measurement of the maxSUV by PET is a simple and noninvasive method to determine the biological cancer cell proliferation potential.
PURPOSE: The aim of this study was to clarify the relationship between the maximum standardized uptake value (maxSUV) and the expression levels of cell-cycle-related molecular biomarkers. PATIENTS AND METHODS: Thirty consecutive patients with non-small cell lung cancer (NSCLC) were enrolled in the study. Histologically, the tumors included 23 adenocarcinomas and 7 squamous cell carcinomas. Protein expressions of Ki-67, proliferating cell nuclear antigen (PCNA), and p53 were examined by immunohistochemistry. RESULTS: The maxSUV was higher in poorly differentiated NSCLCs than in well-differentiated and moderately differentiated tumors (p <0.05). The Ki-67 labeling index was higher in squamous cell carcinomas than in adenocarcinomas (p <0.05), and also in poorly differentiated tumors than in well-differentiated and moderately differentiated tumors (p <0.01). A positive correlation was found between the maxSUV and Ki-67 expression level (r = 0.687, p <0.001). No correlation was found between maxSUV and PCNA expression (r = 0.214, p = 0.248) or between maxSUV and p53 expression (r = 0.357, p = 0.09). Among the molecular biomarkers, an association was found between the expression levels of Ki-67 and PCNA (r = 0.515, p <0.01). CONCLUSIONS: Immunohistochemical staining with Ki-67 in NSCLC correlates with maxSUV. Measurement of the maxSUV by PET is a simple and noninvasive method to determine the biological cancer cell proliferation potential.
Authors: Kyuichi Kadota; Christos Colovos; Kei Suzuki; Nabil P Rizk; Mark P S Dunphy; Emily C Zabor; Camelia S Sima; Akihiko Yoshizawa; William D Travis; Valerie W Rusch; Prasad S Adusumilli Journal: Ann Surg Oncol Date: 2012-05-30 Impact factor: 5.344
Authors: Kyuichi Kadota; Stefan S Kachala; Jun-Ichi Nitadori; Kei Suzuki; Mark P S Dunphy; Camelia S Sima; William D Travis; Valerie W Rusch; Prasad S Adusumilli Journal: J Thorac Oncol Date: 2012-07 Impact factor: 15.609