BACKGROUND: Recent improvements in multidetector computed tomography (MDCT) with 64-slice scanners have allowed acquisition of a coronary study in 5 s to 6 s, with good temporal and spatial resolution. Previous studies have reported an underestimation of plaque burden by MDCT. Whether shorter scan times can allow correct assessment of plaque volume requires comparison with intravascular ultrasound (IVUS). METHODS: Patients (n=30) scheduled for coronary angiography also underwent MDCT and IVUS examinations within 96 h. MDCT examination was performed with a 64-slice scanner. Nitroglycerin was administered before all imaging procedures. MDCT, quantitative coronary angiography (QCA) and IVUS analyses were performed by observers blinded to other results. Plaque volumes were determined by MDCT and IVUS in one vessel, and maximum percentage diameter stenosis was identified in each coronary segment by MDCT and QCA. RESULTS: The mean (+ or - SD) plaque volume was determined to be 179.1 + or - 78.9 mm(3) by MDCT and 176.1 + or - 87.9 mm(3) by IVUS. There was a strong positive correlation for plaque volume between MDCT and IVUS (r=0.84, P<0.0001). Percentage diameter stenosis assessed by MDCT and QCA also correlated well (r=0.88 per patient and r=0.87 per vessel, P<0.0001 for both). The maximum percentage diameter stenosis per vessel was 38.1 + or - 30.2% with MDCT and 34.1 + or - 27.6% with QCA. The sensitivity and specificity of MDCT in detecting stenoses above 50% per vessel were 100% and 91.0%, respectively. CONCLUSIONS: Plaque volumes measured by 64-slice MDCT and IVUS correlate well, without systematic underestimation. The sensitivity and specificity of MDCT to detect stenoses greater than 50% by QCA are excellent with the administration of nitroglycerin before imaging.
BACKGROUND: Recent improvements in multidetector computed tomography (MDCT) with 64-slice scanners have allowed acquisition of a coronary study in 5 s to 6 s, with good temporal and spatial resolution. Previous studies have reported an underestimation of plaque burden by MDCT. Whether shorter scan times can allow correct assessment of plaque volume requires comparison with intravascular ultrasound (IVUS). METHODS:Patients (n=30) scheduled for coronary angiography also underwent MDCT and IVUS examinations within 96 h. MDCT examination was performed with a 64-slice scanner. Nitroglycerin was administered before all imaging procedures. MDCT, quantitative coronary angiography (QCA) and IVUS analyses were performed by observers blinded to other results. Plaque volumes were determined by MDCT and IVUS in one vessel, and maximum percentage diameter stenosis was identified in each coronary segment by MDCT and QCA. RESULTS: The mean (+ or - SD) plaque volume was determined to be 179.1 + or - 78.9 mm(3) by MDCT and 176.1 + or - 87.9 mm(3) by IVUS. There was a strong positive correlation for plaque volume between MDCT and IVUS (r=0.84, P<0.0001). Percentage diameter stenosis assessed by MDCT and QCA also correlated well (r=0.88 per patient and r=0.87 per vessel, P<0.0001 for both). The maximum percentage diameter stenosis per vessel was 38.1 + or - 30.2% with MDCT and 34.1 + or - 27.6% with QCA. The sensitivity and specificity of MDCT in detecting stenoses above 50% per vessel were 100% and 91.0%, respectively. CONCLUSIONS: Plaque volumes measured by 64-slice MDCT and IVUS correlate well, without systematic underestimation. The sensitivity and specificity of MDCT to detect stenoses greater than 50% by QCA are excellent with the administration of nitroglycerin before imaging.
Authors: S Achenbach; T Giesler; D Ropers; S Ulzheimer; H Derlien; C Schulte; E Wenkel; W Moshage; W Bautz; W G Daniel; W A Kalender; U Baum Journal: Circulation Date: 2001-05-29 Impact factor: 29.690
Authors: Fabian Moselewski; Dieter Ropers; Karsten Pohle; Udo Hoffmann; Maros Ferencik; Ray C Chan; Ricardo C Cury; Suhny Abbara; Ik-Kyung Jang; Thomas J Brady; Werner G Daniel; Stephan Achenbach Journal: Am J Cardiol Date: 2004-11-15 Impact factor: 2.778
Authors: Jean-Claude Tardif; Jean Grégoire; Philippe L L'Allier; Todd J Anderson; Olivier Bertrand; Francois Reeves; Lawrence M Title; Fernando Alfonso; Erick Schampaert; Alita Hassan; Richard McLain; Milton L Pressler; Reda Ibrahim; Jacques Lespérance; John Blue; Therese Heinonen; Josep Rodés-Cabau Journal: Circulation Date: 2004-11-08 Impact factor: 29.690
Authors: Paul Schoenhagen; E Murat Tuzcu; Arthur E Stillman; David J Moliterno; Sandra S Halliburton; Stacie A Kuzmiak; Jane M Kasper; William A Magyar; Michael L Lieber; Steven E Nissen; Richard D White Journal: Coron Artery Dis Date: 2003-09 Impact factor: 1.439
Authors: Walid Ben Ali; Pierre Voisine; Peter Skov Olsen; Hugues Jeanmart; Nicolas Noiseux; Tracy Goeken; Vilas Satishchandran; Filippo Cademartiri; Garry Cutter; Dave Veerasingam; Craig Brown; Maximilian Y Emmert; Louis P Perrault Journal: Open Heart Date: 2018-04-13