Literature DB >> 19897377

Catalysis of fluorine addition to double bond: an improvement of method for synthesis of (18)F PET agents.

Alexander V Kachur1, William R Dolbier, Wei Xu, Cameron J Koch.   

Abstract

Catalysis for reaction of electrophilic fluorine addition to a fluorinated double bond is described. The presence of small amounts of iodine, bromine, or boron trifluoride increases an overall product yield and degree of fluorine incorporation, making the reaction a more efficient method for preparation of (18)F positron emission tomography agents. A possible mechanism of catalytic action of iodine is discussed. Copyright (c) 2009 Elsevier Ltd. All rights reserved.

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Year:  2009        PMID： 19897377      PMCID： PMC2818326          DOI： 10.1016/j.apradiso.2009.10.005

Source DB:  PubMed          Journal:  Appl Radiat Isot        ISSN： 0969-8043            Impact factor:   1.513


  3 in total

1.  [18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure.

Authors:  W R Dolbier; A R Li; C J Koch; C Y Shiue; A V Kachur
Journal:  Appl Radiat Isot       Date:  2001-01       Impact factor: 1.513

2.  18F-EF5: a new PET tracer for imaging hypoxia in head and neck cancer.

Authors:  Gaber Komar; Marko Seppänen; Olli Eskola; Paula Lindholm; Tove J Grönroos; Sarita Forsback; Hannu Sipilä; Sydney M Evans; Olof Solin; Heikki Minn
Journal:  J Nucl Med       Date:  2008-11-07       Impact factor: 10.057

3.  Noninvasive imaging of tumor hypoxia in rats using the 2-nitroimidazole 18F-EF5.

Authors:  L S Ziemer; S M Evans; A V Kachur; A L Shuman; C A Cardi; W T Jenkins; J S Karp; A Alavi; W R Dolbier; C J Koch
Journal:  Eur J Nucl Med Mol Imaging       Date:  2002-11-23       Impact factor: 9.236
  3 in total
  8 in total

1.  A simplified synthesis of the hypoxia imaging agent 2-(2-Nitro-1H-imidazol-1-yl)-N-(2,2,3,3,3-[(18)F]pentafluoropropyl)-acetamide ([18F]EF5).

Authors:  Satish K Chitneni; Gerald T Bida; Mark W Dewhirst; Michael R Zalutsky
Journal:  Nucl Med Biol       Date:  2012-06-22       Impact factor: 2.408

2.  High-yielding aqueous 18F-labeling of peptides via Al18F chelation.

Authors:  Christopher A D'Souza; William J McBride; Robert M Sharkey; Louis J Todaro; David M Goldenberg
Journal:  Bioconjug Chem       Date:  2011-08-09       Impact factor: 4.774

Review 3.  Fluorine-18 patents (2009-2015). Part 2: new radiochemistry.

Authors:  Andrew V Mossine; Stephen Thompson; Allen F Brooks; Alexandra R Sowa; Jason M Miller; Peter Jh Scott
Journal:  Pharm Pat Anal       Date:  2016-09

4.  Synthesis and characterization of fluorinated derivatives of cresolsulfonphthalein.

Authors:  Alexander V Kachur; Diana Sardelis; Catherine Bentzley; Anatoliy V Popov; E James Delikatny; Joel Karp
Journal:  J Fluor Chem       Date:  2013-01-01       Impact factor: 2.050

5.  Synthesis of pH indicators for Cerenkov imaging by electrophilic substitution of bromine by fluorine in an aromatic system.

Authors:  Alexander V Kachur; Alejandro D Arroyo; Nikaela W Bryan; Sarah J Saylor; Anatoliy V Popov; E James Delikatny
Journal:  J Fluor Chem       Date:  2017-07-05       Impact factor: 2.050

6.  Direct fluorination of phenolsulfonphthalein: a method for synthesis of positron-emitting indicators for in vivo pH measurement.

Authors:  Alexander V Kachur; Anatoliy V Popov; Joel S Karp; E James Delikatny
Journal:  Cell Biochem Biophys       Date:  2013-05       Impact factor: 2.194

Review 7.  Radiosynthesis of [18)F]trifluoroalkyl groups: scope and limitations.

Authors:  V T Lien; P J Riss
Journal:  Biomed Res Int       Date:  2014-07-10       Impact factor: 3.411

Review 8.  Advances in [18F]Trifluoromethylation Chemistry for PET Imaging.

Authors:  Felix Francis; Frank Wuest
Journal:  Molecules       Date:  2021-10-27       Impact factor: 4.411
  8 in total

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