Literature DB >> 22790882

Direct fluorination of phenolsulfonphthalein: a method for synthesis of positron-emitting indicators for in vivo pH measurement.

Alexander V Kachur1, Anatoliy V Popov, Joel S Karp, E James Delikatny.   

Abstract

We report a reaction of direct electrophilic fluorination of phenolsulfonphthalein at mild conditions. This reaction affords the synthesis of novel positron-emitting (18)F-labeled pH indicators. These compounds are useful for non-invasive in vivo pH measurement in biological objects.

Entities:  

Mesh：

Substances：

Year:  2013        PMID： 22790882      PMCID： PMC4230276          DOI： 10.1007/s12013-012-9390-x

Source DB:  PubMed          Journal:  Cell Biochem Biophys        ISSN： 1085-9195            Impact factor:   2.194


  5 in total

1.  [18F]-EF5, a marker for PET detection of hypoxia: synthesis of precursor and a new fluorination procedure.

Authors:  W R Dolbier; A R Li; C J Koch; C Y Shiue; A V Kachur
Journal:  Appl Radiat Isot       Date:  2001-01       Impact factor: 1.513

Review 2.  Synthesis of 11C, 18F, 15O, and 13N radiolabels for positron emission tomography.

Authors:  Philip W Miller; Nicholas J Long; Ramon Vilar; Antony D Gee
Journal:  Angew Chem Int Ed Engl       Date:  2008       Impact factor: 15.336

Review 3.  [Differences between phthaleins and sulfonphthaleins].

Authors:  Z Tamura; M Maeda
Journal:  Yakugaku Zasshi       Date:  1997-11       Impact factor: 0.302

4.  Synthesis of fluorine-18 labeled rhodamine B: A potential PET myocardial perfusion imaging agent.

Authors:  Tobias K Heinrich; Vijay Gottumukkala; Erin Snay; Patricia Dunning; Frederic H Fahey; S Ted Treves; Alan B Packard
Journal:  Appl Radiat Isot       Date:  2009-08-28       Impact factor: 1.513

5.  Catalysis of fluorine addition to double bond: an improvement of method for synthesis of (18)F PET agents.

Authors:  Alexander V Kachur; William R Dolbier; Wei Xu; Cameron J Koch
Journal:  Appl Radiat Isot       Date:  2009-10-23       Impact factor: 1.513
  5 in total
  6 in total

1.  Core-based lipid nanoparticles as a nanoplatform for delivery of near-infrared fluorescent imaging agents.

Authors:  Nadia Anikeeva; Yuri Sykulev; Edward J Delikatny; Anatoliy V Popov
Journal:  Am J Nucl Med Mol Imaging       Date:  2014-09-06

2.  Direct inhibition of choline kinase by a near-infrared fluorescent carbocyanine.

Authors:  Sean P Arlauckas; Anatoliy V Popov; Edward J Delikatny
Journal:  Mol Cancer Ther       Date:  2014-07-15       Impact factor: 6.261

3.  Synthesis and characterization of fluorinated derivatives of cresolsulfonphthalein.

Authors:  Alexander V Kachur; Diana Sardelis; Catherine Bentzley; Anatoliy V Popov; E James Delikatny; Joel Karp
Journal:  J Fluor Chem       Date:  2013-01-01       Impact factor: 2.050

4.  Cerenkov-specific contrast agents for detection of pH in vivo.

Authors:  Julie Czupryna; Alexander V Kachur; Eric Blankemeyer; Anatoliy V Popov; Alejandro D Arroyo; Joel S Karp; Edward J Delikatny
Journal:  J Nucl Med       Date:  2015-02-05       Impact factor: 10.057

5.  Synthesis of pH indicators for Cerenkov imaging by electrophilic substitution of bromine by fluorine in an aromatic system.

Authors:  Alexander V Kachur; Alejandro D Arroyo; Nikaela W Bryan; Sarah J Saylor; Anatoliy V Popov; E James Delikatny
Journal:  J Fluor Chem       Date:  2017-07-05       Impact factor: 2.050

6.  Synthesis of F-18 labeled resazurin by direct electrophilic fluorination.

Authors:  Alexander V Kachur; Alejandro D Arroyo; Anatoliy V Popov; Sarah J Saylor; E James Delikatny
Journal:  J Fluor Chem       Date:  2015-07-17       Impact factor: 2.050
  6 in total

北京卡尤迪生物科技股份有限公司 © 2022-2023.