Literature DB >> 19892587

Development of a gene transfer-based treatment for radiation-induced salivary hypofunction.

Bruce J Baum1, Changyu Zheng, Ilias Alevizos, Ana P Cotrim, Shuying Liu, Linda McCullagh, Corinne M Goldsmith, Nancy McDermott, John A Chiorini, Nikolay P Nikolov, Gabor G Illei.   

Abstract

A significant long-term side effect of radiation therapy for head and neck cancers is xerostomia, a dry mouth, due to salivary gland damage. Despite continuing efforts to eliminate this problem, many patients continue to suffer. This brief review describes our efforts to develop a gene transfer approach, employing the aquaporin-1 cDNA, to treat patients with existing radiation-induced salivary hypofunction. A Phase I/II clinical trial, using a recombinant adenoviral vector to mediate gene transfer, is currently underway.

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Year:  2009        PMID： 19892587      PMCID： PMC2818419          DOI： 10.1016/j.oraloncology.2009.09.004

Source DB:  PubMed          Journal:  Oral Oncol        ISSN： 1368-8375            Impact factor:   5.337


  38 in total

1.  Safety and efficacy of adenovirus-mediated transfer of the human aquaporin-1 cDNA to irradiated parotid glands of non-human primates.

Authors:  A C O'Connell; L Baccaglini; P C Fox; B C O'Connell; D Kenshalo; H Oweisy; A T Hoque; D Sun; L L Herscher; V R Braddon; C Delporte; B J Baum
Journal:  Cancer Gene Ther       Date:  1999 Nov-Dec       Impact factor: 5.987

2.  Analysis of risk factors for local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of comorbid conditions.

Authors:  Ronald G Crystal; Ben-Gary Harvey; Juan P Wisnivesky; Kelley A O'Donoghue; Karen W Chu; Jaman Maroni; Jolene C Muscat; Allison L Pippo; Connie E Wright; Robert J Kaner; Philip L Leopold; Paul D Kessler; Henrik S Rasmussen; Todd K Rosengart; Charleen Hollmann
Journal:  Hum Gene Ther       Date:  2002-01-01       Impact factor: 5.695

Review 3.  Gene transfer to salivary glands.

Authors:  Bruce J Baum; Robert B Wellner; Changyu Zheng
Journal:  Int Rev Cytol       Date:  2002

4.  Does amifostine have a role in chemoradiation treatment?

Authors:  David M Brizel; Jens Overgaard
Journal:  Lancet Oncol       Date:  2003-06       Impact factor: 41.316

Review 5.  The use of gene transfer for the protection and repair of salivary glands.

Authors:  J M Vitolo; B J Baum
Journal:  Oral Dis       Date:  2002-07       Impact factor: 3.511

Review 6.  Oral sequelae of head and neck radiotherapy.

Authors:  A Vissink; J Jansma; F K L Spijkervet; F R Burlage; R P Coppes
Journal:  Crit Rev Oral Biol Med       Date:  2003

7.  Safety of local delivery of low- and intermediate-dose adenovirus gene transfer vectors to individuals with a spectrum of morbid conditions.

Authors:  Ben-Gary Harvey; Jaman Maroni; Kelley A O'Donoghue; Karen W Chu; Jolene C Muscat; Allison L Pippo; Connie E Wright; Charleen Hollmann; Juan P Wisnivesky; Paul D Kessler; Henrik S Rasmussen; Todd K Rosengart; Ronald G Crystal
Journal:  Hum Gene Ther       Date:  2002-01-01       Impact factor: 5.695

8.  Fatal systemic inflammatory response syndrome in a ornithine transcarbamylase deficient patient following adenoviral gene transfer.

Authors:  Steven E Raper; Narendra Chirmule; Frank S Lee; Nelson A Wivel; Adam Bagg; Guang-ping Gao; James M Wilson; Mark L Batshaw
Journal:  Mol Genet Metab       Date:  2003 Sep-Oct       Impact factor: 4.797

9.  Early hyperbaric oxygen therapy for reducing radiotherapy side effects: early results of a randomized trial in oropharyngeal and nasopharyngeal cancer.

Authors:  David N Teguh; Peter C Levendag; Inge Noever; Peter Voet; Henrie van der Est; Peter van Rooij; Antoine G Dumans; Maarten F de Boer; Michiel P C van der Huls; Wouter Sterk; Paul I M Schmitz
Journal:  Int J Radiat Oncol Biol Phys       Date:  2009-04-20       Impact factor: 7.038

Review 10.  Prevention and treatment of the consequences of head and neck radiotherapy.

Authors:  A Vissink; F R Burlage; F K L Spijkervet; J Jansma; R P Coppes
Journal:  Crit Rev Oral Biol Med       Date:  2003
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  23 in total

1.  Convenient and reproducible in vivo gene transfer to mouse parotid glands.

Authors:  C Zheng; T Shinomiya; C M Goldsmith; G Di Pasquale; B J Baum
Journal:  Oral Dis       Date:  2011-01       Impact factor: 3.511

Review 2.  Dynamics of salivary gland morphogenesis.

Authors:  J Harunaga; J C Hsu; K M Yamada
Journal:  J Dent Res       Date:  2011-04-12       Impact factor: 6.116

3.  Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands.

Authors:  Changyu Zheng; Ana P Cotrim; Anne Rowzee; William Swaim; Anastasia Sowers; James B Mitchell; Bruce J Baum
Journal:  Clin Cancer Res       Date:  2011-03-02       Impact factor: 12.531

4.  Artificial Induction of Native Aquaporin-1 Expression in Human Salivary Cells.

Authors:  Z Wang; S Pradhan-Bhatt; M C Farach-Carson; M J Passineau
Journal:  J Dent Res       Date:  2017-01-10       Impact factor: 6.116

5.  Transduction, tropism, and biodistribution of AAV vectors in the lacrimal gland.

Authors:  Eduardo M Rocha; Giovanni Di Pasquale; Paola Perez Riveros; Kathrina Quinn; Beverly Handelman; John A Chiorini
Journal:  Invest Ophthalmol Vis Sci       Date:  2011-12-20       Impact factor: 4.799

Review 6.  Gene delivery in salivary glands: from the bench to the clinic.

Authors:  Yuval Samuni; Bruce J Baum
Journal:  Biochim Biophys Acta       Date:  2011-07-06

7.  Assessment of the safety and biodistribution of a regulated AAV2 gene transfer vector after delivery to murine submandibular glands.

Authors:  Changyu Zheng; Antonis Voutetakis; Benjamin Goldstein; Sandra Afione; Victor M Rivera; Tim Clackson; Martin L Wenk; Molly Boyle; Abraham Nyska; John A Chiorini; Molly Vallant; Richard D Irwin; Bruce J Baum
Journal:  Toxicol Sci       Date:  2011-05-30       Impact factor: 4.849

8.  Early responses to adenoviral-mediated transfer of the aquaporin-1 cDNA for radiation-induced salivary hypofunction.

Authors:  Bruce J Baum; Ilias Alevizos; Changyu Zheng; Ana P Cotrim; Shuying Liu; Linda McCullagh; Corinne M Goldsmith; Peter D Burbelo; Deborah E Citrin; James B Mitchell; Liesl K Nottingham; Susan F Rudy; Carter Van Waes; Millie A Whatley; Jaime S Brahim; John A Chiorini; Stamatina Danielides; R James Turner; Nicholas J Patronas; Clara C Chen; Nikolay P Nikolov; Gabor G Illei
Journal:  Proc Natl Acad Sci U S A       Date:  2012-11-05       Impact factor: 11.205

9.  Localized Delivery of Amifostine Enhances Salivary Gland Radioprotection.

Authors:  J J Varghese; I L Schmale; D Mickelsen; M E Hansen; S D Newlands; D S W Benoit; V A Korshunov; C E Ovitt
Journal:  J Dent Res       Date:  2018-04-10       Impact factor: 6.116

Review 10.  Cost-effectiveness landscape analysis of treatments addressing xerostomia in patients receiving head and neck radiation therapy.

Authors:  Laura S Sasportas; Drew N Hosford; Maria A Sodini; Dale J Waters; Elizabeth A Zambricki; Joëlle K Barral; Edward E Graves; Todd J Brinton; Paul G Yock; Quynh-Thu Le; Davud Sirjani
Journal:  Oral Surg Oral Med Oral Pathol Oral Radiol       Date:  2013-05-03
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