Literature DB >> 11837896

Gene transfer to salivary glands.

Bruce J Baum1, Robert B Wellner, Changyu Zheng.   

Abstract

This article provides a review of the application of gene transfer technology to studies of salivary glands. Salivary glands provide an uncommon target site for gene transfer but offer many experimental situations likely of interest to the cell biologist. The reader is provided with a concise overview of salivary biology, along with a general discussion of the strategies available for gene transfer to any tissue. In particular, adenoviral vectors have been useful for proof of concept studies with salivary glands. Several examples are given, using adenoviral-mediated gene transfer, for addressing both biological and clinical questions. Additionally, benefits and shortcomings affecting the utility of this technology are discussed.

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Year:  2002        PMID： 11837896     DOI： 10.1016/s0074-7696(02)13013-0

Source DB:  PubMed          Journal:  Int Rev Cytol        ISSN： 0074-7696


  27 in total

Review 1.  Use of localised gene transfer to develop new treatment strategies for the salivary component of Sjögren's syndrome.

Authors:  M R Kok; B J Baum; P P Tak; S R Pillemer
Journal:  Ann Rheum Dis       Date:  2003-11       Impact factor: 19.103

2.  Cloning and characterization of a bovine adeno-associated virus.

Authors:  Michael Schmidt; Hisako Katano; Ioannis Bossis; John A Chiorini
Journal:  J Virol       Date:  2004-06       Impact factor: 5.103

3.  Convenient and reproducible in vivo gene transfer to mouse parotid glands.

Authors:  C Zheng; T Shinomiya; C M Goldsmith; G Di Pasquale; B J Baum
Journal:  Oral Dis       Date:  2011-01       Impact factor: 3.511

Review 4.  Experience with experimental biological treatment and local gene therapy in Sjogren's syndrome: implications for exocrine pathogenesis and treatment.

Authors:  B M Lodde; B J Baum; P P Tak; G Illei
Journal:  Ann Rheum Dis       Date:  2006-07-31       Impact factor: 19.103

5.  Evaluation of promoters for use in tissue-specific gene delivery.

Authors:  Changyu Zheng; Bruce J Baum
Journal:  Methods Mol Biol       Date:  2008

6.  Prevention of radiation-induced salivary hypofunction following hKGF gene delivery to murine submandibular glands.

Authors:  Changyu Zheng; Ana P Cotrim; Anne Rowzee; William Swaim; Anastasia Sowers; James B Mitchell; Bruce J Baum
Journal:  Clin Cancer Res       Date:  2011-03-02       Impact factor: 12.531

7.  Persistence of hAQP1 expression in human salivary gland cells following AdhAQP1 transduction is associated with a lack of methylation of hCMV promoter.

Authors:  C Zheng; B J Baum; X Liu; C M Goldsmith; P Perez; S-I Jang; A P Cotrim; L McCullagh; I S Ambudkar; I Alevizos
Journal:  Gene Ther       Date:  2015-07-16       Impact factor: 5.250

8.  Transient TWEAK overexpression leads to a general salivary epithelial cell proliferation.

Authors:  T Sugito; F Mineshiba; C Zheng; A P Cotrim; C M Goldsmith; B J Baum
Journal:  Oral Dis       Date:  2008-09-29       Impact factor: 3.511

9.  Extended transgene expression from a nonintegrating adenoviral vector containing retroviral elements.

Authors:  Changyu Zheng; Joseph M Vitolo; Weitian Zhang; Fumi Mineshiba; John A Chiorini; Bruce J Baum
Journal:  Mol Ther       Date:  2008-03-25       Impact factor: 11.454

10.  Reengineered salivary glands are stable endogenous bioreactors for systemic gene therapeutics.

Authors:  Antonis Voutetakis; Marc R Kok; Changyu Zheng; Ioannis Bossis; Jianghua Wang; Ana P Cotrim; Natanya Marracino; Corinne M Goldsmith; John A Chiorini; Y Peng Loh; Lynnette K Nieman; Bruce J Baum
Journal:  Proc Natl Acad Sci U S A       Date:  2004-02-20       Impact factor: 11.205
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