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Literature DB >> 21763423

Gene delivery in salivary glands: from the bench to the clinic.

Abstract

In vivo gene delivery has long been seen as providing opportunities for the development of novel treatments for disorders refractory to existing therapies. Over the last two decades, salivary glands have proven to be a useful, if somewhat unconventional, target tissue for studying several potential clinical applications of therapeutic gene delivery. Herein, we follow the progress, address some problems and assess the outlook for clinical applications of salivary gland gene delivery. Our experience with these tissues provides a roadmap for the process of moving an idea from the laboratory bench to patients. Published by Elsevier B.V.

Entities: Chemical Disease Gene Species

Mesh：

Year: 2011 PMID： 21763423 PMCID： PMC3185128 DOI： 10.1016/j.bbadis.2011.06.014

Source DB: PubMed Journal: Biochim Biophys Acta ISSN： 0006-3002

86 in total

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Review 3. Pathogenesis of Sjögren's syndrome.

Authors: Nikolay P Nikolov; Gabor G Illei
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4. Conditional overexpression of TGF-beta1 disrupts mouse salivary gland development and function.

Authors: Bradford E Hall; Changyu Zheng; William D Swaim; Andrew Cho; Chandrasekharam N Nagineni; Michael A Eckhaus; Kathleen C Flanders; Indu S Ambudkar; Bruce J Baum; Ashok B Kulkarni
Journal: Lab Invest Date: 2010-02-08 Impact factor: 5.662

5. Effect of irradiation on microvascular endothelial cells of parotid glands in the miniature pig.

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6. Effect of human vasoactive intestinal peptide gene transfer in a murine model of Sjogren's syndrome.

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7. Repetitive adenovirus administration to the parotid gland: role of immunological barriers and induction of oral tolerance.

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8. Transient detection of E1-containing adenovirus in saliva after the delivery of a first-generation adenoviral vector to human parotid gland.

Authors: Changyu Zheng; Nikolay P Nikolov; Ilias Alevizos; Ana P Cotrim; Shuying Liu; Linda McCullagh; John A Chiorini; Gabor G Illei; Bruce J Baum
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9. Sorting of transgenic secretory proteins in rhesus macaque parotid glands after adenovirus-mediated gene transfer.

Authors: Antonis Voutetakis; Changyu Zheng; Mark Metzger; Ana P Cotrim; Robert E Donahue; Cynthia E Dunbar; Bruce J Baum
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10. Developing a convenient large animal model for gene transfer to salivary glands in vivo.

Authors: Jun Li; Chanyu Zheng; Xin Zhang; Xiaoyong Liu; Chengmei Zhang; Corinne M Goldsmith; Bruce J Baum; Songlin Wang
Journal: J Gene Med Date: 2004-01 Impact factor: 4.565

28 in total

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2. Development of a Primary Human Cell Model for the Study of Human Cytomegalovirus Replication and Spread within Salivary Epithelium.

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3. Hydrophobic oxime ethers: a versatile class of pDNA and siRNA transfection lipids.

Authors: Souvik Biswas; Ralph J Knipp; Laura E Gordon; Seshagiri R Nandula; Sven-Ulrik Gorr; Geoffrey J Clark; Michael H Nantz
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Authors: Szilvia Arany; Danielle S W Benoit; Stephen Dewhurst; Catherine E Ovitt
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Review 5. Treatment of late sequelae after radiotherapy for head and neck cancer.

Authors: Primož Strojan; Katherine A Hutcheson; Avraham Eisbruch; Jonathan J Beitler; Johannes A Langendijk; Anne W M Lee; June Corry; William M Mendenhall; Robert Smee; Alessandra Rinaldo; Alfio Ferlito
Journal: Cancer Treat Rev Date: 2017-07-18 Impact factor: 12.111

6. In vivo Endocrine Secretion of Prostacyclin Following Expression of a Cyclooxygenase-1/Prostacyclin Fusion Protein in the Salivary Glands of Rats Via Nonviral Gene Therapy.

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Journal: Hum Gene Ther Date: 2017-08 Impact factor: 5.695