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Literature DB >> 19890912

Muscleblind-like 1 is a negative regulator of TGF-beta-dependent epithelial-mesenchymal transition of atrioventricular canal endocardial cells.

Natalie A Vajda¹, Kyle R Brimacombe, Kathryn E LeMasters, Andrea N Ladd.

Abstract

The development of the valves and septa of the heart depends on the formation and remodeling of endocardial cushions. Here, we report that the alternative splicing regulator muscleblind-like 1 (MBNL1) exhibits a regionally restricted pattern of expression in canal region endocardium and ventricular myocardium during endocardial cushion development in chicken. Knockdown of MBNL1 in atrioventricular explants leads to a transforming growth factor beta-dependent increase in epithelial-mesenchymal transition (EMT) of endocardial cells. This reveals a novel role for MBNL1 during embryonic development, and represents the first evidence that an alternative splicing regulator is a key player in endocardial cushion development. (c) 2009 Wiley-Liss, Inc.

Entities: Chemical Disease Gene Species

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Year: 2009 PMID： 19890912 PMCID： PMC2844348 DOI： 10.1002/dvdy.22155

Source DB: PubMed Journal: Dev Dyn ISSN： 1058-8388 Impact factor: 3.780

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Journal: Mol Ther Date: 2020-12-03 Impact factor: 11.454

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Journal: Genes Dev Date: 2016-02-15 Impact factor: 11.361