Literature DB >> 19883122

Reduced digestive vacuolar accumulation of chloroquine is not linked to resistance to chloroquine toxicity.

Mynthia Cabrera1, Michelle F Paguio, Changan Xie, Paul D Roepe.   

Abstract

Chloroquine (CQ) accumulation studies in live malaria parasites are typically conducted at low nanomolar CQ concentrations, and definition of CQ resistance (CQR) has been via growth inhibition assays versus low-dose CQ (i.e., via IC(50) ratios). These data have led to the nearly universally accepted idea that reduced parasite CQ accumulation is the underlying basis of CQR. Surprisingly, when quantifying CQR via cytocidal CQ activity and examining CQ accumulation at medically relevant LD(50) doses, we find reduced CQ accumulation is not the underlying cause of CQR.

Entities:  

Mesh：

Substances：

Year:  2009        PMID： 19883122      PMCID： PMC2788207          DOI： 10.1021/bi901765v

Source DB:  PubMed          Journal:  Biochemistry        ISSN： 0006-2960            Impact factor:   3.162


  17 in total

1.  Evidence for a substrate specific and inhibitable drug efflux system in chloroquine resistant Plasmodium falciparum strains.

Authors:  Cecilia P Sanchez; Jeremy E McLean; Wilfred Stein; Michael Lanzer
Journal:  Biochemistry       Date:  2004-12-28       Impact factor: 3.162

Review 2.  Apoptosis-like death as a feature of malaria infection in mosquitoes.

Authors:  H Hurd; K M Grant; S C Arambage
Journal:  Parasitology       Date:  2006       Impact factor: 3.234

3.  PfCRT and the trans-vacuolar proton electrochemical gradient: regulating the access of chloroquine to ferriprotoporphyrin IX.

Authors:  Patrick G Bray; Mathirut Mungthin; Ian M Hastings; Giancarlo A Biagini; Dauda K Saidu; Viswanathan Lakshmanan; David J Johnson; Ruth H Hughes; Paul A Stocks; Paul M O'Neill; David A Fidock; David C Warhurst; Stephen A Ward
Journal:  Mol Microbiol       Date:  2006-08-31       Impact factor: 3.501

4.  Drug-induced death of the asexual blood stages of Plasmodium falciparum occurs without typical signs of apoptosis.

Authors:  Alice M Nyakeriga; Hedvig Perlmann; Margareta Hagstedt; Klavs Berzins; Marita Troye-Blomberg; Boris Zhivotovsky; Peter Perlmann; Alf Grandien
Journal:  Microbes Infect       Date:  2006-04-18       Impact factor: 2.700

5.  Features of apoptosis in Plasmodium falciparum erythrocytic stage through a putative role of PfMCA1 metacaspase-like protein.

Authors:  Benoît Meslin; Céline Barnadas; Vanessa Boni; Christine Latour; Frédérique De Monbrison; Karine Kaiser; Stéphane Picot
Journal:  J Infect Dis       Date:  2007-05-07       Impact factor: 5.226

6.  Plasmodium falciparum: in vitro studies of the pharmacodynamic properties of drugs used for the treatment of severe malaria.

Authors:  F ter Kuile; N J White; P Holloway; G Pasvol; S Krishna
Journal:  Exp Parasitol       Date:  1993-02       Impact factor: 2.011

7.  Chloroquine resistance in malaria: a deficiency of chloroquine binding.

Authors:  C D Fitch
Journal:  Proc Natl Acad Sci U S A       Date:  1969-12       Impact factor: 11.205

Review 8.  Antimalarial dosing regimens and drug resistance.

Authors:  Karen I Barnes; William M Watkins; Nicholas J White
Journal:  Trends Parasitol       Date:  2008-02-11

9.  Clonal viability measurements on Plasmodium falciparum to assess in vitro schizonticidal activity of leupeptin, chloroquine, and 5-fluoroorotate.

Authors:  R D Young; P K Rathod
Journal:  Antimicrob Agents Chemother       Date:  1993-05       Impact factor: 5.191

10.  Chloroquine transport in Plasmodium falciparum. 1. Influx and efflux kinetics for live trophozoite parasites using a novel fluorescent chloroquine probe.

Authors:  Mynthia Cabrera; Jayakumar Natarajan; Michelle F Paguio; Christian Wolf; Jeffrey S Urbach; Paul D Roepe
Journal:  Biochemistry       Date:  2009-10-13       Impact factor: 3.162
View more
  22 in total

1.  Differential drug efflux or accumulation does not explain variation in the chloroquine response of Plasmodium falciparum strains expressing the same isoform of mutant PfCRT.

Authors:  Adele M Lehane; Donelly A van Schalkwyk; Stephanie G Valderramos; David A Fidock; Kiaran Kirk
Journal:  Antimicrob Agents Chemother       Date:  2011-02-22       Impact factor: 5.191

2.  A chemotype that inhibits three unrelated pathogenic targets: the botulinum neurotoxin serotype A light chain, P. falciparum malaria, and the Ebola filovirus.

Authors:  Igor Opsenica; James C Burnett; Rick Gussio; Dejan Opsenica; Nina Todorović; Charlotte A Lanteri; Richard J Sciotti; Montip Gettayacamin; Nicoletta Basilico; Donatella Taramelli; Jonathan E Nuss; Laura Wanner; Rekha G Panchal; Bogdan A Solaja; Sina Bavari
Journal:  J Med Chem       Date:  2011-01-25       Impact factor: 7.446

3.  Autophagy in Apicomplexa: a life sustaining death mechanism?

Authors:  Anthony P Sinai; Paul D Roepe
Journal:  Trends Parasitol       Date:  2012-07-18

4.  Synthesis, structure-activity relationship, and mode-of-action studies of antimalarial reversed chloroquine compounds.

Authors:  Steven J Burgess; Jane X Kelly; Shawheen Shomloo; Sergio Wittlin; Reto Brun; Katherine Liebmann; David H Peyton
Journal:  J Med Chem       Date:  2010-09-09       Impact factor: 7.446

Review 5.  PfCRT and its role in antimalarial drug resistance.

Authors:  Andrea Ecker; Adele M Lehane; Jérôme Clain; David A Fidock
Journal:  Trends Parasitol       Date:  2012-09-25

6.  Balancing drug resistance and growth rates via compensatory mutations in the Plasmodium falciparum chloroquine resistance transporter.

Authors:  Ines Petersen; Stanislaw J Gabryszewski; Geoffrey L Johnston; Satish K Dhingra; Andrea Ecker; Rebecca E Lewis; Mariana Justino de Almeida; Judith Straimer; Philipp P Henrich; Eugene Palatulan; David J Johnson; Olivia Coburn-Flynn; Cecilia Sanchez; Adele M Lehane; Michael Lanzer; David A Fidock
Journal:  Mol Microbiol       Date:  2015-05-20       Impact factor: 3.501

7.  Analysis of chloroquine resistance transporter (CRT) isoforms and orthologues in S. cerevisiae yeast.

Authors:  Nicholas K Baro; Chaya Pooput; Paul D Roepe
Journal:  Biochemistry       Date:  2011-07-19       Impact factor: 3.162

8.  Purified Plasmodium falciparum multi-drug resistance protein (PfMDR 1) binds a high affinity chloroquine analogue.

Authors:  Perri Pleeter; Jacqueline K Lekostaj; Paul D Roepe
Journal:  Mol Biochem Parasitol       Date:  2010-06-01       Impact factor: 1.759

9.  Determination of the cytostatic and cytocidal activities of antimalarial compounds and their combination interactions.

Authors:  Katy S Sherlach; Paul D Roepe
Journal:  Curr Protoc Chem Biol       Date:  2014-12-01

10.  Function of resistance conferring Plasmodium falciparum chloroquine resistance transporter isoforms.

Authors:  Nicholas K Baro; Paul S Callaghan; Paul D Roepe
Journal:  Biochemistry       Date:  2013-06-06       Impact factor: 3.162
View more

北京卡尤迪生物科技股份有限公司 © 2022-2023.