Literature DB >> 19870836

INFECTIOUS MYXOMATOSIS OF RABBITS : STUDIES OF A SOLUBLE ANTIGEN ASSOCIATED WITH THE DISEASE.

T M Rivers1, S M Ward, J E Smadel.   

Abstract

The soluble antigen of myxoma is a heat-labile protein which has an isoelectric point near pH 4.5 and is precipitated from half saturated solutions of ammonium sulfate. It can be partially purified by methods of differential precipitation based on variations in the pH and electrolyte concentration. Rabbits receiving the labile, soluble substance of myxoma develop homologous precipitins and their serum agglutinates elementary bodies of myxoma, provided the dermal pulp from which the bodies are obtained contains the soluble substance; neutralizing antibodies do not appear, however, and the animals are not resistant to infection with the virus of myxoma. Elementary bodies of myxoma appear to have a heat-stable agglutinogen that operates when brought in contact with serum from animals recovered from myxoma, but little, if at all, when in contact with anti-soluble substance serum.

Entities:  

Year:  1939        PMID： 19870836      PMCID： PMC2133719          DOI： 10.1084/jem.69.1.31

Source DB:  PubMed          Journal:  J Exp Med        ISSN： 0022-1007            Impact factor:   14.307


  5 in total

1.  IMMUNOLOGICAL STUDIES OF A HEAT-STABLE SUBSTANCE ISOLATED FROM TISSUES INFECTED WITH VACCINE VIRUS.

Authors:  R F Parker
Journal:  J Exp Med       Date:  1938-02-28       Impact factor: 14.307

2.  IMMUNOLOGICAL AND CHEMICAL INVESTIGATIONS OF VACCINE VIRUS : VI. ISOLATION OF A HEAT-STABLE, SEROLOGICALLY ACTIVE SUBSTANCE FROM TISSUES INFECTED WITH VACCINE VIRUS.

Authors:  R F Parker; T M Rivers
Journal:  J Exp Med       Date:  1937-01-31       Impact factor: 14.307

3.  STUDIES ON THE SOLUBLE PRECIPITABLE SUBSTANCES OF VACCINIA : II. THE SOLUBLE PRECIPITABLE SUBSTANCES OF DERMAL VACCINE.

Authors:  J Craigie; F O Wishart
Journal:  J Exp Med       Date:  1936-10-31       Impact factor: 14.307

4.  IMMUNOLOGICAL AND CHEMICAL INVESTIGATIONS OF VACCINE VIRUS : III. RESPONSE OF RABBITS TO INACTIVE ELEMENTARY BODIES OF VACCINIA AND TO VIRUS-FREE EXTRACTS OF VACCINE VIRUS.

Authors:  R F Parker; T M Rivers
Journal:  J Exp Med       Date:  1936-01-01       Impact factor: 14.307

5.  INFECTIOUS MYXOMATOSIS OF RABBITS : PREPARATION OF ELEMENTARY BODIES AND STUDIES OF SEROLOGICALLY ACTIVE MATERIALS ASSOCIATED WITH THE DISEASE.

Authors:  T M Rivers; S M Ward
Journal:  J Exp Med       Date:  1937-06-30       Impact factor: 14.307
  5 in total
  1 in total

1.  A SOLUBLE ANTIGEN OF LYMPHOCYTIC CHORIOMENINGITIS : II. CHARACTERISTICS OF THE ANTIGEN AND ITS USE IN PRECIPITIN REACTIONS.

Authors:  J E Smadel; M J Wall; R D Baird
Journal:  J Exp Med       Date:  1940-01-01       Impact factor: 14.307
  1 in total

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