Literature DB >> 19865586

FLOW DYNAMIC COMPARISON BETWEEN RECESSED HINGE AND OPEN PIVOT BI-LEAFLET HEART VALVE DESIGNS.

V Govindarajan1, H S Udaykumar, K B Chandran.   

Abstract

The flow dynamics through the peripheral and hinge regions of a bi-leaflet mechanical heart valve are complex and result in abnormally high shear stresses particularly during the closing phase of the valve function. It has been observed that, the late stages of closure is more significant in the dynamics of platelet activation; therefore, the later stages of closure is simulated by solving the two-dimensional Navier-Stokes equations using an Eulerian Levelset based sharp interface Cartesian grid method. Using a fixed Cartesian mesh incorporating local mesh refinement for solution accuracy and efficiency, the flow through and within a recessed hinge design and an open pivot hinge design is compared. Platelets are modelled as point particles by Lagrangian particle tracking algorithm with one way coupling. A dilute particle flow is assumed and particle-particle interactions are neglected. It was observed that the hinge region of the open pivot valve indicated a lower potential for activation of platelets compared to that in valves with a recessed hinge design.

Entities:  

Year:  2009        PMID: 19865586      PMCID: PMC2768291          DOI: 10.1142/S0219519409002912

Source DB:  PubMed          Journal:  J Mech Med Biol        ISSN: 0219-5194            Impact factor:   0.897


  18 in total

1.  Bioprosthetic heart valve leaflet motion monitored by dual camera stereo photogrammetry.

Authors:  Z B Gao; S Pandya; N Hosein; M S Sacks; N H Hwang
Journal:  J Biomech       Date:  2000-02       Impact factor: 2.712

2.  Platelet activation in a circulating flow loop: combined effects of shear stress and exposure time.

Authors:  Jolyon Jesty; Wei Yin; Peter Perrotta; Danny Bluestein
Journal:  Platelets       Date:  2003-05       Impact factor: 3.862

3.  Dynamics of blood flow and platelet transport in pathological vessels.

Authors:  Shmuel Einav; Danny Bluestein
Journal:  Ann N Y Acad Sci       Date:  2004-05       Impact factor: 5.691

4.  Flow-induced platelet activation in mechanical heart valves.

Authors:  Danny Bluestein; Wei Yin; Klaus Affeld; Jolyon Jesty
Journal:  J Heart Valve Dis       Date:  2004-05

5.  Two-dimensional dynamic simulation of platelet activation during mechanical heart valve closure.

Authors:  S Krishnan; H S Udaykumar; J S Marshall; K B Chandran
Journal:  Ann Biomed Eng       Date:  2006-09-30       Impact factor: 3.934

6.  A microstructural flow analysis within a bileaflet mechanical heart valve hinge.

Authors:  J M Gross; M C Shu; F F Dai; J Ellis; A P Yoganathan
Journal:  J Heart Valve Dis       Date:  1996-11

7.  The response of human platelets to shear stress at short exposure times.

Authors:  G Colantuoni; J D Hellums; J L Moake; C P Alfrey
Journal:  Trans Am Soc Artif Intern Organs       Date:  1977

8.  Shear-induced activation of platelets.

Authors:  J M Ramstack; L Zuckerman; L F Mockros
Journal:  J Biomech       Date:  1979       Impact factor: 2.712

9.  Velocity measurements and flow patterns within the hinge region of a Medtronic Parallel bileaflet mechanical valve with clear housing.

Authors:  J T Ellis; T M Healy; A A Fontaine; R Saxena; A P Yoganathan
Journal:  J Heart Valve Dis       Date:  1996-11

Review 10.  Thromboembolic and bleeding complications in patients with mechanical heart valve prostheses.

Authors:  S C Cannegieter; F R Rosendaal; E Briët
Journal:  Circulation       Date:  1994-02       Impact factor: 29.690

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  1 in total

1.  Role of Computational Simulations in Heart Valve Dynamics and Design of Valvular Prostheses.

Authors:  Krishnan B Chandran
Journal:  Cardiovasc Eng Technol       Date:  2010-03       Impact factor: 2.495

  1 in total

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